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Effects of praziquantel and oxamniquine on a Saudi Arabian strain of Schistosoma mansoni in mice

Published online by Cambridge University Press:  05 June 2009

A. M. Ghandour ,
A. A. Banaja  and
I. M. Shalaby
A. M. Ghandour
Affiliation:
Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, P.O. Box 9028, Saudi Arabia
A. A. Banaja
Affiliation:
Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, P.O. Box 9028, Saudi Arabia
I. M. Shalaby
Affiliation:
Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, P.O. Box 9028, Saudi Arabia
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Abstract

The prophylactic and curative effects of praziquantel and oxamniquine on a Saudi Arabian strain of Schistosoma mansoni in MF-1 mice were assessed. The drugs were administered orally. At 240 mg/kg praziquantel, there was a reduction of 89·1% in adult worm recovery and a marked reduction in tissue deposited eggs. The reduction in adult worm recovery after dosing with 50 mg/kg oxamniquine was 89·2%. At low doses (40 mg/kg praziquantel and 30 mg/kg oxamniquine) administered at 11 days, 5 days and 3 h before and 5, 21 and 49 days after infection, the reduction in adult worm recovery was 0·0%, 65·1%, 58·8%, 33·6%, 0·0% and 76·0% for praziquantel and 0·0%, 66·0%, 60·0%, 41·3%, 10·8% and 79·0% for oxamniquine. Numbers of lung schistosomula and the size of hepatic granulomata were also reduced.

Keywords

Schistosoma mansonimouseoxamniquinechemotherapyprophylaxis
Type
Research Note
Information
Journal of Helminthology , Volume 64 , Issue 1 , March 1990 , pp. 62 - 64
Copyright
Copyright © Cambridge University Press 1990

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References

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