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Anticestode activity of 3, 5-dibromo-2' -chlorosalicylanilide-4' -isothiocyanate—a preliminary report*

Published online by Cambridge University Press:  05 June 2009

Suman Gupta ,
J. C. Katiyar ,
A. B. Sen ,
S. K. Dubey ,
H. Singh ,
S. Sharma  and
R. N. Iyer
Suman Gupta
Affiliation:
Division of parasitology, Central Drug Research Institute, Lucknow-226001, India
J. C. Katiyar
Affiliation:
Division of parasitology, Central Drug Research Institute, Lucknow-226001, India
A. B. Sen
Affiliation:
Division of parasitology, Central Drug Research Institute, Lucknow-226001, India
S. K. Dubey
Affiliation:
Medicinal Chemistry Division, Central Drug Research Institute, Lucknow-226001, India
H. Singh
Affiliation:
Medicinal Chemistry Division, Central Drug Research Institute, Lucknow-226001, India
S. Sharma
Affiliation:
Medicinal Chemistry Division, Central Drug Research Institute, Lucknow-226001, India
R. N. Iyer
Affiliation:
Medicinal Chemistry Division, Central Drug Research Institute, Lucknow-226001, India
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Extract

Many compounds have been claimed to possess powerful taenicidal activity but only a few are able to remove the tapeworms complete with scolices; accordingly better drugs are still needed. A series of 3, 5-dibromosalicylanilides, possessing a molecular framework similar to that of niclosamide (Gönnert and Schraufstätter, 1960) was tested for taenicidal activity; the most potent anticestode compound was found to be 3, 5-dibromo-2' -chlorosalicylanilide-4' -isothiocyanate (CDRI Compound 77–6). The present communication compares the efficacy of Compound 77–6 with niclosamide, N-(2' -chloro-4-nitrophenyl)-5-chlorosalicylamid (Bayer, power with 75% active ingredient) and praziquantel, 2-cyclohexylcarbonyl-1–3, 4, 6, 7, 11 b-hexahydro-2H-Pyrazino [2–1-a], isoquinoline-4-one (Droncit, E. Merck & Bayer, powder, 100% pure) (Seubert et al., 1977) in rats and mice.

Type
Research Note
Information
Journal of Helminthology , Volume 54 , Issue 4 , December 1980 , pp. 271 - 273
Copyright
Copyright © Cambridge University Press 1980

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References

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