Hostname: page-component-745bb68f8f-grxwn Total loading time: 0 Render date: 2025-01-20T17:12:19.657Z Has data issue: false hasContentIssue false
  • English
  • Français

The anthelmintic effects of a new compound “E” (Friedheim) on Onchocerca gutturosa in the cow—a possible tertiary screening system for drug action against O. volvulus in man

Published online by Cambridge University Press:  05 June 2009

D. A. Denham  and
P. Mellor
D. A. Denham
Affiliation:
Department of Medical Helminthology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT
P. Mellor
Affiliation:
Department of Medical Helminthology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT
Get access Rights & Permissions [Opens in a new window]

Abstract

Three cows were treated with different levels of compound “E” which is known to have strong filaricidal activity. In all three animals the number of microfilariae of Onchocerca gutturosa declined after treatment. At autopsy most of the adult worms found were dead and in those still living embryogenesis appeared to have ceased.

It is concluded that, despite the disadvantages, this system represents a possible way of assessing onchocercicidal activity before undertaking human trials.

Type
Research Article
Information
Journal of Helminthology , Volume 50 , Issue 1 , March 1976 , pp. 49 - 52
Copyright
Copyright © Cambridge University Press 1976

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Duke, B.O.L. (1974a) The effect of levamisole on Onchocerca volulus. Transactions of the Royal Society of Tropical Medicine and Hygiene, 68, 71.CrossRefGoogle Scholar
Duke, B.O.L. (1974b) Mebendazole—ineffective against Onchocerca volvulus. Transactions of the Royal Society of Tropical Medicine and Hygiene, 68, 172.CrossRefGoogle ScholarPubMed
Duke, B.O.L. (1974c) The effect of Suramin on the immature forms of Onchocera volvulus in the vertebrate host. Zeitschrift für Tropenmedizin und Parasitologie, 25, 84–88.Google Scholar
Düwel, D. (1973) Studies in rodents and dogs with a new macro- and micro-filaricidal compound. Proceedings of the Ninth International Congress on Tropical Medicine and Malaria, 2, 117.Google Scholar
Eichler, D.A. and Nelson, G.S. (1971) Studies on Onchocerca gutturosa (Neumann, 1910) and its development in Simulium ornatum (Meigen, 1818). 1. Observations on O. gutturosa in South-East England. Journal of Helminthology, 45, 245–258.CrossRefGoogle Scholar
Friedheim, E.A.H. (1974) Therapeutic field trial of a macro- and micro-filaricidal agent in canine filariasis. Bulletin of the World Health Organization, 50, 572–574.Google Scholar
Mellor, P.S. (1973) Studies on Onchocerca cervicalis Railliet and Henry 1910: 1. Onchocerca cervicalis in British horses. Journal of Helminthology, 45, 97–110.CrossRefGoogle Scholar