Hostname: page-component-745bb68f8f-b95js Total loading time: 0 Render date: 2025-01-09T17:31:34.079Z Has data issue: false hasContentIssue false
  • English
  • Français

An evaluation of the efficacy of monensin against Fasciola hepatica in the albino rat

Published online by Cambridge University Press:  05 June 2009

P. J. Skuce ,
I. Fairweather  and
J. W. M. Kenny
P. J. Skuce
Affiliation:
Department of Zoology, The Queen's University of Belfast, Belfast, BT7 INN
I. Fairweather
Affiliation:
Department of Zoology, The Queen's University of Belfast, Belfast, BT7 INN
J. W. M. Kenny
Affiliation:
Division of Parasitology, Veterinary Research Laboratories, Stormont
Get access Rights & Permissions [Opens in a new window]

Abstract

The in vivo efficacy of monensin against Fasciola hepatica was determined in the albino rat. The results were variable, with monensin generally showing greater activity against juvenile (two-week-old) than adult (12-week-old) fludes. Significant (p<0·005) reductions in worm burdens were obtained only following treatment of adult flukes with 2×10 mg/kg monensin (52·9% efficacy), and of juvenile flukes with 1×10 mg/kg (42·4% efficacy) and 2×10 mg/kg (56·23% efficacy). Monensin administered in the diet (200 ppm) had a negligible effect on juvenile and adult fluke burdens. Prophylactic treatment of rats with monensin (100 ppm) produced a 45·5% efficacy, but this was not statistically significant. At doses of 1×5 mg/kg and 2×2·5 mg/kg, monensin had little effect on egg output by F. hepatica. No clear relationship was established between egg output and worm burden, and so faecal egg counting was not a reliable indicator of fluke burdens in the rat.

Keywords

MonensinratFasciola hepaticaefficacy
Type
Research Papers
Information
Journal of Helminthology , Volume 61 , Issue 1 , March 1987 , pp. 53 - 58
Copyright
Copyright © Cambridge University Press 1987

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Boray, J.C., Happich, F.A. & Andrews, J.C. (1967) Studies on the suitability of the albino rat for testing anthelmintic activity against Fasciola hepatica. Annals of Tropical Medicine and Parasilology, 61, 104–111.CrossRefGoogle ScholarPubMed
Boucoué, C.V., Fiems, L.O., Cottyn, B.G., Casteels, M. & Buysse, F.X. (1982) Monensin-sodium as a performance-promoting additive for fattening bulls and its impact on carcass and meat quality characteristics. Animal Feed Science and Technology, 7, 401–410.CrossRefGoogle Scholar
Coles, G.C. (1975) Activity of commercial fasciolicides in small laboratory mammals. Journal of Parasitology, 61, 54–58.CrossRefGoogle Scholar
Coles, G.C. (1976) The inactivity of diamphenethide against liver fluke in certain species of mammals. Research in Veterinary Science, 20, 110–111CrossRefGoogle ScholarPubMed
Daenicke, R., Rohr, K. & Oslage, H.J. (1982) Effect of monensin on rumen fermentation. performance and body composition of growing bulls. livestock Production Science, 8, 479–488.CrossRefGoogle Scholar
Donoho, A., Manthey, J., Occolowitz, J. & Zornes, L. (1978) Metabolism of monensin in the steer and rat. Journal of Agricutureal Food Chemistry, 26, 1090–1095.CrossRefGoogle ScholarPubMed
Enzie, F.D., Rew, R.S. & Colglazier, M.L. (1980) Chemoprophylaxis with diamfenetide against experimental infections of Fasciola hepatica in ruminants. American Journal of Veterinary Research, 41, 179–182.Google ScholarPubMed
Fairweather, I. & Skuce, P.J. (1985) An evaluation of the fasciolicdal potential of monensin. I. The effect of monensin on the neuromuscular and osmoregulatory systems of Fasciola hepatica. Proceedings of the Spring Meeting of the British Society for Parasitology, University of Nottingham, March 1985. p. 59. Parasitology, 91, 420.Google Scholar
Happich, F.A. & Boray, J.C. (1969) Quantitative diagnosis of chronic fasciolosis. 2. The estimation of daily total egg production of Fasciola hepatica and the number of adult flukes in sheep by faecal egg counts. Australian Veterinary Journal, 45, 329–331.CrossRefGoogle ScholarPubMed
Hayes, T.J., Bailer, J. & Mitrovic, M. (1974) The effect of administration of known fasciolicides in the diet to rats infected with Fasciola hepatica. Journal of Parasitology, 60 545–546.CrossRefGoogle ScholarPubMed
Holmes, S.D. (1983) In vitro studies into the mode of action of anthlemintics on the liver fluke Fasciola hepatica L. Ph.D. Thesis, The Queen's Univeirsity of Belfast.Google Scholar
Knight, R.A. (1984) Quantitation of Fasciola hepatica egg counts in sheep. Proceedings of the Helminthological Society of Washington, 51, 349–351.Google Scholar
Lämmler, G. (1959) Die chemotherapie der fasciolose. III. Mitteilung: über die experimentelle Fasciola hepatica—infection der albino-ratte. Zeitschrift für Tropenmedizin und Parasitologie, 10, 379–384.Google Scholar
Powers, K.G., Wood, I.B., Eckert, J., Gibson, T. & Smith, H.J. (1982) world Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) guidelines for evaluating the efficacy of anthelmintics in ruminants (bovine and ovine). Veterinary Parasitology, 10, 265–284.CrossRefGoogle ScholarPubMed
Pressman, B.C. & Fahim, M. (1982) Pharmacology and toxicology of the monovalent carboxylic ionophores. Annual Review of Pharmacology and Toxicology, 22, 465–490.CrossRefGoogle ScholarPubMed
Raun, A.P., Cooley, C.O., Potter, E.L., Rathmacher, R.P. & Richardson, L.F. (1976) Effect of monensin on feed efficiency of feedlot cattle. Journal of Animal Science, 43, 670–677.CrossRefGoogle Scholar
Ray, R.J. (1970.) Studies on the effect of various anthelminticis upon Fasiola hepatica in albino rats. Research in Veterinary Science, 11, 1–6.CrossRefGoogle Scholar
Rew, R.S., Enzie, F.D. & Colglazier, M.L. (1980) Diamfenetide as a controlled-release prophylactic fasciolicide in sheep: daily oral doses, continual infusion, and serum drug levels. International Goat and Sheep Research, 1, 96–103.Google Scholar
Richardson, L.F., Raun, A.P., Potter, E.L., Cooley, C.O. & Rathmacher, R.P. (1976) Effect of monensin on rumen fermentation in vitro and in vivo. Journal of Animal Science, 43, 657–664.CrossRefGoogle Scholar
Shumard, R.F. & Callender, M.E. (1968) Monensin, a new biologically active compound. 6. Anticoccidial activity. Antimicrobial Agents and Chemotherapy—1967, 369–377.Google Scholar
Skuce, P.J. & Fairweather, I. (1985) An evaluation of fasciolicidal potential of monensin. 2. The effect of monensin on egg production and results of efficacy studies in the rat. Proceedings of the Spring Meeting of the British Society for Parasitology, University of Nottingham, March 1985, p. 59. Parasitology, 91, 420.Google Scholar
Sokal, R.R. & Rohlf, F.J. (1981) Biometry: The Principles and Practice of Statistics in Biological Research. Second Edition. W.H. Freeman and Company: San Francisco.Google Scholar
Tartakoff, A.M. (1983) Perturbation of vesicular traffic with the carboxylic ionophore monensin. Cell, 32, 1026–1028.CrossRefGoogle ScholarPubMed
Thorpe, E. (1965) Chemotherapy of experimental fascioliasis in the albino rat. Journal of Comparative Pathology, 75, 45–53.CrossRefGoogle Scholar