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Activation in vitro of some biological systems by extracts of adult worms and microfilariae of Dirofilaria immitis

Published online by Cambridge University Press:  05 June 2009

P.F.L. Boreham
P.F.L. Boreham
Affiliation:
Queensland Institute of Medical Research, Bramston Terrace, Herston, Queensland 4006, Australia
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Abstract

Extracts of Dirofilaria immitis adults and microfilariae cause the dcgranulation of mast cells in rat mesentery when applied in vitro and also cause increased vascular permeability in guinea-pigs and rabbits. Adult worms DUt not microfilariac are able to activate complement in vitro and both stages contain a plasminogen activator. No protcolytic activity or hacmolysins could be detected in cither stage. The possibility that these factors may be important in the pathogencsis of dirofilariasis and in the adverse drug reactions that may follow treatment of microfilaraemic animals with dicthylcarbamazine is discussed.

Type
Research Article
Information
Journal of Helminthology , Volume 58 , Issue 3 , September 1984 , pp. 207 - 212
Copyright
Copyright © Cambridge University Press 1984

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