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3,5-Dibromo-2'-chloro-4'-isothiocyanato salicylanilide in the control of Hymenolepis nana in rats—a pilot study

Published online by Cambridge University Press:  18 November 2009

Suman Gupta ,
J. C. Katiyar ,
S. Sharma  and
A. B. Sen
Suman Gupta
Affiliation:
Central Drug Research Institut, Lucknow 226001, India,
J. C. Katiyar
Affiliation:
Central Drug Research Institut, Lucknow 226001, India,
S. Sharma
Affiliation:
Central Drug Research Institut, Lucknow 226001, India,
A. B. Sen
Affiliation:
Central Drug Research Institut, Lucknow 226001, India,
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Abstract

The efficiency of a new anticestode compound, 3,5-dibromo-2'-chloro-4'-isothiocyanato salicylanilide (GUPTA et al. 1980) for mass eradication of hymenolepiasis from rat colonies was assessed in a pilot study. The drug was administered with milk or food. For effective eradication, depending on the size of animals, single or multiple doses of 100 to 500 mg of the drug'kg body-weight, mixed in milk, or 50mg/kg in feed were necessary. Better results were obtained when the compound was given in feed as it ensured effective consumption irrespective of the seasonal variations. The efficacy of the compound was also assessed on cysticcrcoids in intermediate hosts (Tribalium confusum) by feeding them on flour medicated at 5%, l% and 0.1% levels. None of the concentrations killed the larvae or arrested their development.

Type
Research Article
Information
Journal of Helminthology , Volume 58 , Issue 1 , March 1984 , pp. 7 - 11
Copyright
Copyright © Cambridge University Press 1984

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References

REFERENCES

Almeida, I.S. DE (1979) Therapeutic action of mebendazole on multiple enteroparasitic infections in children in N.S. de Fatima-Planaltina-DF–1978. Revista do Institute de Medicina Tropical de São Paulo, 21, 339–343.Google Scholar
Cavier, R. & Notteghem, M.J. (1979) Pharmacological study of taenicidal properties of two anthelmintic benzimidazole derivatives: mebendazole and flubendazole. Annales pharmaceutiques Françaises, 37, 33–36.Google Scholar
Evans, W.S., Gray, B. & Novak, M. (1979) Effect of mebendazole on the larval development of three hymenolepidid cestodes. Journal of Parasitology, 65, 31–34.CrossRefGoogle ScholarPubMed
Evans, W.S. & Novak, M. (1976) The effect of mebendazole on the development of Hymenolepis diminuta in Tribolium confusum. Canadian Journal of Zoology, 54, 1079–1083.CrossRefGoogle ScholarPubMed
Gupta, S. (1982) Studies on some Aspects of Chemotherapy and Immunology of Experimental Cestode Infection. Ph.D. Thesis, Kanpur University.Google Scholar
Gupta, S. & Katiyar, J.C. (1983) Comparative rapidity of action of anticestode drugs, praziquantel, Niclosamide and Compound 77–6, against Hymenolepis nana. Journal of Helminthology, 57, 31–36.CrossRefGoogle Scholar
Gupta, S., Katiyar, J.C., Sen, A.B., Dubey, S.K., Singh, H., Sharma, S. & Iyer, R.N. (1980) Anticestode activity of 3,5-dibromo-2-chlorosalicylanilide-4-isothiocyanate: a preliminary report. Journal of Helminthology, 54, 271–273.CrossRefGoogle ScholarPubMed
Gupta, S., Katiyar, J.C. & Sen, A.B. (1981) Effect of mode of infection on the development and chemotherapeutic response of Hymenolepis nana in rats. Journal of Helminthology, 55, 101–107.CrossRefGoogle ScholarPubMed
Heyneman, D. (1962). Studies on helminth immunity 1—comparison between lumenal and tissue phases of infection in the white mouse by Hymenolepis nana (Cestoda: Hymenolepididae). American Journal of Tropical Medicine and Hygiene, 11, 46–63.CrossRefGoogle Scholar
Katiyar, J.C., Visen, P.K.S., Gupta, S., Sen, A.B., Dubey, S.K. & Sharma, S. (1982). 3,5 Dibromo-2-chloro-4-isothiocyanato salicylanilide, a potent anthelmintic, Experientia, 38, 457–460.CrossRefGoogle ScholarPubMed
Krotov, A.I., Bajandina, D.G. & Naidenova, A.S. (1975) The effect of levamisole, Dibasol and mebendazole on experimental H. nana infection in white mice. Problemy parazitologii Material VIII Nauchnoi Konferentsii Parazitologov UR SSR Pt. i. Kiev USSR Isdatelstvo “Naukova Dumka” 277–278. [In Russian.]Google Scholar
Novak, M. & Evans, W.S. (1978) The effect of mebendazole on different developmental stages of Hymenolepis diminuta cysticercoids. Canadian Journal of Zoology, 56, 604–607.CrossRefGoogle ScholarPubMed