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Intermittency and synchronized motion of red blood cell dynamics in shear flow

Published online by Cambridge University Press:  24 October 2014

Daniel Cordasco  and
Prosenjit Bagchi
Daniel Cordasco
Affiliation:
Mechanical and Aerospace Engineering Department, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
Prosenjit Bagchi*
Affiliation:
Mechanical and Aerospace Engineering Department, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
*
†Email address for correspondence: [email protected]
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Abstract

We present the first full-scale computational evidence of intermittent and synchronized dynamics of red blood cells in shear flow. These dynamics are characterized by the coexistence of a tumbling motion in which the cell behaves like a rigid body and a tank-treading motion in which the cell behaves like a liquid drop. In the intermittent dynamics, we observe sequences of tumbling interrupted by swinging, as well as sequences of swinging interrupted by tumbling. In the synchronized dynamics, the tumbling and membrane rotation are observed to occur simultaneously with integer ratios of the rotational frequencies. These dynamics are shown to be dependent on the stress-free state of the cytoskeleton, and are explained based on the cell membrane energy landscape.

JFM classification

Biological Fluid Dynamics: Biological Fluid Dynamics Biological Fluid Dynamics: Blood flow Biological Fluid Dynamics: Capsule/cell dynamics
Type
Papers
Information
Journal of Fluid Mechanics , Volume 759 , 25 November 2014 , pp. 472 - 488
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Copyright
© 2014 Cambridge University Press 

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Cordasco and Bagchi supplementary movie

Intermittent dynamics corresponding to Figure 2a.

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Video 14.1 MB
Supplementary material: File

Cordasco and Bagchi supplementary material

Supplementary figures

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File 1.8 MB

Cordasco and Bagchi supplementary movie

Intermittent dynamics corresponding to Figure 2a.

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Video 2.6 MB

Cordasco and Bagchi supplementary movie

Animation corresponding to Figure 2c.

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Video 18.6 MB

Cordasco and Bagchi supplementary movie

Synchronized motion corresponding to Figure 5.

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Video 1.8 MB

Cordasco and Bagchi supplementary movie

Synchronized dynamics with frequency ratio of 3.

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Video 13.1 MB