We study the pressure-driven transient motion of a periodic file of deformable liquid drops through a cylindrical tube with circular cross-section, at vanishing Reynolds number. The investigations are based on numerical solutions of the equations of Stokes flow obtained by the boundary-integral method. It is assumed that the viscosity and density of the drops are equal to those of the suspending fluid, and the interfaces have constant tension. The mathematical formulation uses the periodic Green's function of the equations of Stokes flow in a domain that is bounded externally by a cylindrical tube, which is computed by tabulation and interpolation. The surface of each drop is discretized into quadratic triangular elements that form an unstructured interfacial grid, and the tangential velocity of the grid-points is adjusted so that the mesh remains regular for an extended but limited period of time. The results illustrate the nature of drop motion and deformation, and thereby extend previous studies for axisymmetric flow and small-drop small-deformation theories. It is found that when the capillary number is sufficiently small, the drops start deforming from a spherical shape, and then reach slowly evolving quasi-steady shapes. In all cases, the drops migrate radially toward the centreline after an initial period of rapid deformation. The apparent viscosity of the periodic suspension is expressed in terms of the effective pressure gradient necessary to drive the flow at constant flow rate. For a fixed period of separation, the apparent viscosity of a non-axisymmetric file is found to be higher than that of an axisymmetric file. In the case of non-axisymmetric motion, the apparent viscosity reaches a minimum at a certain ratio of the drop separation to tube radius. Drops with large effective radii to tube radius ratios develop slipper shapes, similar to those assumed by red blood cells in flow through capillaries, but only for capillary numbers in excess of a critical value.