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Vitamin D exposure during pregnancy, but not early childhood, is associated with risk of childhood wheezing

Published online by Cambridge University Press:  17 April 2015

L. N. Anderson Open the ORCID record for L. N. Anderson [Opens in a new window] ,
Y. Chen ,
J. A. Omand ,
C. S. Birken ,
P. C. Parkin ,
T. To ,
J. L. Maguire  and
the TARGet Kids Collaboration
L. N. Anderson*
Affiliation:
Division of Pediatric Medicine and the Pediatric Outcomes Research Team, The Hospital for Sick Children, Toronto, Ontario, Canada Department of Pediatrics, St. Michael’s Hospital, Toronto, Ontario, Canada
Y. Chen
Affiliation:
The Applied Health Research Centre of the Li Ka Shing Knowledge Institute of St. Michael’s Hospital, Toronto, Ontario, Canada
J. A. Omand
Affiliation:
Department of Pediatrics, St. Michael’s Hospital, Toronto, Ontario, Canada Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
C. S. Birken
Affiliation:
Division of Pediatric Medicine and the Pediatric Outcomes Research Team, The Hospital for Sick Children, Toronto, Ontario, Canada Child Health Evaluative Sciences, The Hospital for Sick Children Research Institute, Toronto, Canada Institute for Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada Department of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
P. C. Parkin
Affiliation:
Division of Pediatric Medicine and the Pediatric Outcomes Research Team, The Hospital for Sick Children, Toronto, Ontario, Canada Child Health Evaluative Sciences, The Hospital for Sick Children Research Institute, Toronto, Canada Institute for Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada Department of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
T. To
Affiliation:
Division of Pediatric Medicine and the Pediatric Outcomes Research Team, The Hospital for Sick Children, Toronto, Ontario, Canada Child Health Evaluative Sciences, The Hospital for Sick Children Research Institute, Toronto, Canada Institute for Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada
J. L. Maguire
Affiliation:
Department of Pediatrics, St. Michael’s Hospital, Toronto, Ontario, Canada The Applied Health Research Centre of the Li Ka Shing Knowledge Institute of St. Michael’s Hospital, Toronto, Ontario, Canada Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada Institute for Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada Department of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
*
*Address for correspondence: L. N. Anderson, The Hospital for Sick Children, Division of Paediatric Medicine, 686 Bay Street, Rm. 109832, Peter Gilgan Centre for Research and Learning, Toronto, Ontario, Canada M5G 0A4.(Email: [email protected])
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Abstract

The association between vitamin D and wheezing in early childhood is unclear. The primary objective of this study was to evaluate the association between vitamin D exposure, during both pregnancy and childhood, and early childhood wheezing. Secondary objectives were to evaluate the associations between vitamin D exposures and asthma and wheezing severity. We conducted a cohort study of children (0–5 years) recruited from 2008 to 2013 through the TARGet Kids! primary-care research network. Vitamin D exposures included maternal vitamin D supplement use during pregnancy, child vitamin D supplementation and children’s 25-hydroxyvitamin D (25(OH)D) concentrations. The outcomes measured were parent-reported childhood wheezing, diagnosed asthma and wheezing severity. Vitamin D supplement and wheezing data were available for 2478 children, and blood samples were available for 1275 children. Adjusted odds ratios (aOR) were estimated using logistic regression adjusted for age, sex, ethnicity, body mass index, birth weight, outdoor play, breastfeeding duration, daycare status, parental smoking and family history of asthma. Vitamin D supplementation during pregnancy was associated with lower odds of childhood wheezing (aOR=0.65; 95% CI: 0.46–0.93). In early childhood, neither 25(OH)D (aOR per 10 nmol/l=1.01; 95% CI: 0.96–1.06) nor vitamin D supplementation (aOR=1.00; 95% CI: 0.81–1.23) was associated with wheezing. No significant associations were observed with diagnosed asthma or wheezing severity. Vitamin D supplementation during pregnancy was associated with reduced odds of wheezing, but child vitamin D supplementation and childhood 25(OH)D were not associated with reduced wheezing. The timing of exposure may be important in understanding the association between vitamin D and childhood wheezing.

Keywords

asthmachildpre-schoolvitamin Dwheezing
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 6 , Issue 4 , August 2015 , pp. 308 - 316
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Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2015 

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Footnotes

†

TARGet Kids! Collaboration – Scientific Committee: Kawsari Abdullah, Laura N. Anderson, Catherine S. Birken, Cornelia M. Borkhoff, Sarah Carsley, Yang Chen, Matthew D’Ascanio, Mikael Katz-Lavigne, Kanthi Kavikondala, Grace Jieun Lee, Jonathon L. Maguire, Jessica Omand, Patricia C. Parkin, Navindra Persaud, Meta van den Heuvel, Weeda Zabih; Site Investigators: Jillian Baker, Tony Barozzino, Joey Bonifacio, Douglas Campbell, Sohail Cheema, Brian Chisamore, Karoon Danayan, Paul Das, Mary Beth Derocher, Anh Do, Michael Dorey, Sloane Freeman, Keewai Fung, Charlie Guiang, Curtis Handford, Hailey Hatch, Sheila Jacobson, Tara Kiran, Holly Knowles, Bruce Kwok, Sheila Lakhoo, Margarita Lam-Antoniades, Eddy Lau, Fok-Han Leung, Jennifer Loo, Sarah Mahmoud, Rosemary Moodie, Julia Morinis, Sharon Naymark, Patricia Neelands, James Owen, Michael Peer, Marty Perlmutar, Navindra Persaud, Andrew Pinto, Michelle Porepa, Nasreen Ramji, Noor Ramji, Alana Rosenthal, Janet Saunderson, Rahul Saxena, Michael Sgro, Susan Shepherd, Barbara Smiltnieks, Carolyn Taylor, Thea Weisdors, Sheila Wijayasinghe, Peter Wong, Ethel Ying, Elizabeth Young.

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