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Self-reported depression and anxiety after prenatal famine exposure: mediation by cardio-metabolic pathology?

Published online by Cambridge University Press:  16 February 2011

S. R. de Rooij ,
R. C. Painter ,
D. I. Phillips ,
K. Räikkönen ,
A. H. Schene  and
T. J. Roseboom
S. R. de Rooij*
Affiliation:
Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
R. C. Painter
Affiliation:
Department of Gynecology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
D. I. Phillips
Affiliation:
MRC Epidemiology Resource Centre, Southampton General Hospital, Southampton, UK
K. Räikkönen
Affiliation:
Department of Psychology, University of Helsinki, Helsinki, Finland
A. H. Schene
Affiliation:
Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
T. J. Roseboom
Affiliation:
Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
*
*Address for correspondence: Dr S. R. de Rooij, Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. (Email [email protected])
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Abstract

Evidence from previous studies suggests an association between prenatal exposure to famine and increased risk for depression. The aim of this study was to investigate whether prenatal exposure to the Dutch famine is associated with self-reported depression/anxiety and whether a potential association is mediated by the presence of cardio-metabolic disease. A total of 819 persons, born as term singletons around the 1944–1945 Dutch famine, filled out the Hospital Anxiety and Depression Scale (HADS) and were asked about their medical history. As indicators of cardio-metabolic disease we included type 2 diabetes (T2D), hypertension and coronary heart disease (CHD). In the total study population, exposure to famine during early gestation was associated with the presence of self-reported mild-to-severe anxiety. Evidence was found for several interactions between exposure in early gestation and sex. Subsequent analyses according to sex showed that men exposed to famine during early gestation scored higher on the HADS depression scale. Self-reported mild-to-severe anxiety symptoms were more prevalent among early exposed men. No such differences were found in women. T2D and hypertension were not correlated with any of the depression and anxiety measures. Adjusting for the presence of CHD did minimally attenuate the size of the reported associations. In conclusion, the present results do not match those previously reported in prenatally famine-exposed individuals. We found only weak evidence for an association between prenatal famine exposure and symptoms of depression and anxiety, which was shown exclusively in men exposed during early gestation.

Keywords

anxietycardiovascular diseasedevelopmental originsdepressionmetabolic disease
Type
Original Articles
Information
Journal of Developmental Origins of Health and Disease , Volume 2 , Issue 3 , June 2011 , pp. 136 - 143
Copyright
Copyright © Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2011

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References

1. Vessey, MP, Fairweather, DV, Norman-Smith, B, Buckley, J. A randomized double-blind controlled trial of the value of stilboestrol therapy in pregnancy: long-term follow-up of mothers and their offspring. Br J Obstet Gynaecol. 1983; 90, 1007–1017.CrossRefGoogle ScholarPubMed
2. Machon, RA, Mednick, SA, Huttunen, MO. Adult major affective disorder after prenatal exposure to an influenza epidemic. Arch Gen Psychiatry. 1997; 54, 322–328.CrossRefGoogle Scholar
3. Watson, JB, Mednick, SA, Huttunen, M, Wang, X. Prenatal teratogens and the development of adult mental illness. Dev Psychopathol. 1999; 11, 457–466.CrossRefGoogle ScholarPubMed
4. Brown, AS, Susser, ES, Lin, SP, Neugebauer, R, Gorman, JM. Increased risk of affective disorders in males after second trimester prenatal exposure to the Dutch Hunger Winter of 1944–45. Br J Psychiatry. 1995; 166, 601–606.CrossRefGoogle Scholar
5. Brown, A, Van Os, J, Driessens, C, Hoek, H, Susser, E. Further evidence of relation between prenatal famine and major affective disorder. Am J Psychiatry. 2000; 157, 190–195.CrossRefGoogle ScholarPubMed
6. Stein, AD, Pierik, FH, Verrips, GH, Susser, ES, Lumey, LH. Maternal exposure to the dutch famine before conception and during pregnancy: quality of life and depressive symptoms in adult offspring. Epidemiology. 2009; 20, 909–915.CrossRefGoogle Scholar
7. Barker, DJP. Mothers, Babies and Health in Later Life, 2nd edn, 1998. Edinburgh: Churchill Livingstone.Google Scholar
8. Thompson, C, Syddall, H, Rodin, I, Osmond, C, Barker, DJP. Birth weight and the risk of depressive disorder in later life. Br J Psychiatry. 2001; 179, 450–455.CrossRefGoogle Scholar
9. Anderson, RJ, Freedland, KE, Clouse, RE, Lustman, PJ. The prevalence of comorbid depression in adults with diabetes: a meta-analysis. Diabetes Care. 2001; 24, 1069–1078.CrossRefGoogle ScholarPubMed
10. Collins, MM, Corcoran, P, Perry, IJ. Anxiety and depression symptoms in patients with diabetes. Diabet Med. 2009; 26, 153–161.CrossRefGoogle ScholarPubMed
11. Fan, AZ, Strine, TW, Jiles, R, Mokdad, AH. Depression and anxiety associated with cardiovascular disease among persons aged 45 years and older in 38 states of the United States, 2006. Prev Med. 2008; 46, 445–450.CrossRefGoogle Scholar
12. Katon, WJ. The comorbidity of diabetes mellitus and depression. Am J Med. 2008; 121, S8–S15.CrossRefGoogle ScholarPubMed
13. Mezuk, B, Eaton, WW, Albrecht, S, Golden, SH. Depression and type 2 diabetes over the lifespan: a meta-analysis. Diabetes Care. 2008; 31, 2383–2390.CrossRefGoogle ScholarPubMed
14. Jacobson, AM, Samson, JA, Weinger, K, Ryan, CM. Diabetes, the brain, and behavior: is there a biological mechanism underlying the association between diabetes and depression? Int Rev Neurobiol. 2002; 51, 455–479.CrossRefGoogle Scholar
15. Mosovich, SA, Boone, RT, Reichenberg, A, et al. New insights into the link between cardiovascular disease and depression. Int J Clin Pract. 2008; 62, 423–432.CrossRefGoogle Scholar
16. Roseboom, T, de Rooij, S, Painter, R. The Dutch famine and its long-term consequences for adult health. Early Hum Dev. 2006; 82, 485–491.CrossRefGoogle ScholarPubMed
17. Trienekens, G. Tussen ons volk en de honger, 1st edn, 1985. Utrecht: Matrijs.Google Scholar
18. Burger, GCE, Sandstead, HR, Drummond, JC. Malnutrition and Starvation in Western Netherlands, September 1944 to July 1945. Part I and II, 1948. The Hague: General State Printing Office.Google Scholar
19. Zigmond, AS, Snaith, RP. The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983; 67, 361–370.CrossRefGoogle ScholarPubMed
20. Abiodun, OA. A validity study of the hospital anxiety and depression scale in general hospital units and a community sample in Nigeria. Br J Psychiatry. 1994; 165, 669–672.CrossRefGoogle Scholar
21. Bjelland, I, Dahl, AA, Haug, TT, Neckelmann, D. The validity of the hospital anxiety and depression scale. An updated literature review. J Psychosom Res. 2002; 52, 69–77.CrossRefGoogle ScholarPubMed
22. Ravelli, ACJ, van der Meulen, JHP, Michels, RPJ, et al. Glucose tolerance in adults after prenatal exposure to famine. Lancet. 1998; 351, 173–177.CrossRefGoogle ScholarPubMed
23. Bakker, B, Sieben, I. Maten voor prestige, sociaal-economische status en sociale klasse voor de standaard beroepenclassificatie 1992. Soc Wetenschap. 1997; 40, 1–22.Google Scholar
24. McCance, RA. Critical periods of growth. Proc Nutr Soc. 1976; 35, 309–313.CrossRefGoogle ScholarPubMed
25. Eriksson, JG, Kajantie, E, Osmond, C, Thornburg, K, Barker, DJ. Boys live dangerously in the womb. Am J Hum Biol. 2010; 22, 330–335.CrossRefGoogle ScholarPubMed
26. Crawford, JR, Henry, JD, Crombie, C, Taylor, EP. Normative data for the HADS from a large non-clinical sample. Br J Clin Psychol. 2001; 40, 429–434.CrossRefGoogle ScholarPubMed
27. Andrews, B, Hejdenberg, J, Wilding, J. Student anxiety and depression: comparison of questionnaire and interview assessments. J Affect Disord. 2006; 95, 29–34.CrossRefGoogle ScholarPubMed
28. Spinhoven, P, Ormel, J, Sloekers, P, et al. A validation study of the hospital anxiety scale (HADS) in different groups of Dutch subjects. Psychol Med. 1997; 27, 363–370.CrossRefGoogle ScholarPubMed
29. Kessler, RC, McGonagle, KA, Zhao, S, et al. Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity survey. Arch Gen Psychiatry. 1994; 51, 8–19.CrossRefGoogle ScholarPubMed