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Placental fatty acid transport in maternal obesity

Published online by Cambridge University Press:  14 June 2012

I. Cetin ,
F. Parisi ,
C. Berti ,
C. Mandò  and
G. Desoye
I. Cetin*
Affiliation:
Department of Clinical Sciences L. Sacco, Unit of Obstetrics and Gynecology, University of Milan, Milano, Italy
F. Parisi
Affiliation:
Department of Clinical Sciences L. Sacco, Unit of Obstetrics and Gynecology, University of Milan, Milano, Italy
C. Berti
Affiliation:
Department of Clinical Sciences L. Sacco, Unit of Obstetrics and Gynecology, University of Milan, Milano, Italy
C. Mandò
Affiliation:
Department of Clinical Sciences L. Sacco, Unit of Obstetrics and Gynecology, University of Milan, Milano, Italy
G. Desoye
Affiliation:
Department of Obstetrics and Gynaecology, Medical University of Graz, Graz, Austria
*
*Address for correspondence: Prof. I. Cetin, Department of Clinical Sciences L. Sacco, Unit of Obstetrics and Gynecology, University of Milan, via GB Grassi 74, 20157 Milan, Italy. Email [email protected]
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Abstract

Pregestational obesity is a significant risk factor for adverse pregnancy outcomes. Maternal obesity is associated with a specific proinflammatory, endocrine and metabolic phenotype that may lead to higher supply of nutrients to the feto-placental unit and to excessive fetal fat accumulation. In particular, obesity may influence placental fatty acid (FA) transport in several ways, leading to increased diffusion driving force across the placenta, and to altered placental development, size and exchange surface area. Animal models show that maternal obesity is associated with increased expression of specific FA carriers and inflammatory signaling molecules in placental cotyledonary tissue, resulting in enhanced lipid transfer across the placenta, dislipidemia, fat accumulation and possibly altered development in fetuses. Cell culture experiments confirmed that inflammatory molecules, adipokines and FA, all significantly altered in obesity, are important regulators of placental lipid exchange. Expression studies in placentas of obese–diabetic women found a significant increase in FA binding protein-4 expression and in cellular triglyceride content, resulting in increased triglyceride cord blood concentrations. The expression and activity of carriers involved in placental lipid transport are influenced by the endocrine, inflammatory and metabolic milieu of obesity, and further studies are needed to elucidate the strong association between maternal obesity and fetal overgrowth.

Keywords

fatty acidsmaternal obesityplacental transportpregnancy
Type
Review
Information
Journal of Developmental Origins of Health and Disease , Volume 3 , Issue 6 , December 2012 , pp. 409 - 414
Copyright
Copyright © Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2012 

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