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Periconception maternal smoking and low education are associated with methylation of INSIGF in children at the age of 17 months

Published online by Cambridge University Press:  11 May 2012

S. A. Obermann-Borst ,
B. T. Heijmans ,
P. H. C. Eilers ,
E. W. Tobi ,
E. A. P. Steegers ,
P. E. Slagboom  and
R. P. M. Steegers-Theunissen
S. A. Obermann-Borst
Affiliation:
Department of Obstetrics and Gynaecology, Eramus MC, University Medical Centre, Rotterdam, The Netherlands
B. T. Heijmans
Affiliation:
Department of Molecular Epidemiology, LUMC, University Medical Centre, Leiden, The Netherlands The Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands
P. H. C. Eilers
Affiliation:
Department of Biostatistics, Eramus MC, University Medical Centre, Rotterdam, The Netherlands
E. W. Tobi
Affiliation:
Department of Molecular Epidemiology, LUMC, University Medical Centre, Leiden, The Netherlands
E. A. P. Steegers
Affiliation:
Department of Obstetrics and Gynaecology, Eramus MC, University Medical Centre, Rotterdam, The Netherlands
P. E. Slagboom
Affiliation:
Department of Molecular Epidemiology, LUMC, University Medical Centre, Leiden, The Netherlands The Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands
R. P. M. Steegers-Theunissen*
Affiliation:
Department of Obstetrics and Gynaecology, Eramus MC, University Medical Centre, Rotterdam, The Netherlands Department of Epidemiology, Eramus MC, University Medical Centre, Rotterdam, The Netherlands Department of Clinical Genetics, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands
*
*Address for correspondence: Dr R. P. M. Steegers-Theunissen, Professor in Periconception Epidemiology, Erasmus MC, University Medical Centre, Department of Obstetrics and Gynaecology, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands. (Email [email protected])
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Abstract

Maternal smoking during pregnancy and a low socioeconomic status (SES) lead to increased risks of adverse pregnancy outcome. Maternal education is often used as proxy for SES. We explored the programming of the insulin pathway genes IGF2 DMR (insulin growth factor 2 differentially methylated region), IGF2R (insulin growth factor 2 receptor) and INSIGF [the overlapping region of IGF2 and insulin (INS)] in the child through any periconception maternal smoking and education level. In 120 children at 17 months of age, methylation of DNA derived from white blood cells was measured. Periconception smoking and low education were independently associated with INSIGF methylation and showed a relative increase in methylation of +1.3%; P = 0.043 and +1.6%; P = 0.021. Smoking and low education showed an additive effect on INSIGF methylation (+2.8%; P = 0.011). There were no associations with IGF2 DMR and IGF2R methylation. Our data suggest that periconception maternal smoking and low education are associated with epigenetic marks on INSIGF in the very young child, this warrants further study in additional populations.

Keywords

CpG sitesIGF2 DMRIGF2RINSIGFmethylation
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 3 , Issue 5 , October 2012 , pp. 315 - 320
Copyright
Copyright © Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2012

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References

1. Villalbi, JR, Salvador, J, Cano-Serral, G, Rodriquez-Sanz, MC, Borrell, C. Maternal Smoking, social class and outcomes of pregnancy. Paediatr Perinatal Epidemiol. 2007; 21, 441–447.CrossRefGoogle ScholarPubMed
2. Doherty, SP, Grabowski, J, Hoffman, C, Ng, SP, Zelikoff, JT. Early life insult from cigarette smoke may be predictive of chronic diseases later in life. Biomarkers. 2009; 14, 97–101.CrossRefGoogle ScholarPubMed
3. Jirtle, RL, Skinner, MK. Environmental epigenomics and disease susceptibility. Nat Rev Genet. 2007; 8, 253–262.CrossRefGoogle ScholarPubMed
4. Jaenisch, R, Bird, A. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet. 2003; 33, 245–254.CrossRefGoogle ScholarPubMed
5. Barker, DJ. In utero programming of chronic disease. Clin Sci (Lond). 1998; 95, 115–128.CrossRefGoogle ScholarPubMed
6. Baker, J, Liu, JP, Robertson, EJ, Efstratiadis, A. Role of insulin-like growth factors in embryonic and postnatal growth. Cell. 1993; 75, 73–82.CrossRefGoogle ScholarPubMed
7. Adkins, RM, Somes, G, Morrison, JC, et al. . Association of birth weight with polymorphisms in the IGF2, H19, and IGF2R genes. Pediatr Res. 2010; 68, 429–434.Google ScholarPubMed
8. Adkins, RM, Krushkal, J, Klauser, CK, et al. . Association between small for gestational age and paternally inherited 5′ insulin haplotypes. Int J Obes. 2008; 32, 372–380.CrossRefGoogle ScholarPubMed
9. Tobi, EW, Lumey, LH, Talens, RP, et al. . DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific. Hum Mol Genet. 2009; 18, 4046–4053.CrossRefGoogle ScholarPubMed
10. Godfrey, KM, Barker, DJ. Fetal nutrition and adult disease. Am J Clin Nutr. 2000; 71, 1344–1352.CrossRefGoogle ScholarPubMed
11. Heijmans, BT, Tobi, EW, Stein, AD, et al. . Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proc Natl Acad Sci U S A. 2008; 105, 17046–17049.CrossRefGoogle ScholarPubMed
12. Tobi, EW, Heijmans, BT, Kremer, D, et al. . DNA methylation of IGF2, GNASAS, INSIGF and LEP and being born small for gestational age. Epigenetics. 2011; 6, 171–176.CrossRefGoogle ScholarPubMed
13. Breton, CV, Byun, HM, Wenten, M, et al. . Prenatal tobacco smoke exposure affects global and gene-specific DNA methylation. Am J Respir Crit Care Med. 2009; 180, 462–467.CrossRefGoogle ScholarPubMed
14. Terry, MB, Ferris, JS, Pilsner, R, et al. . Genomic DNA methylation among women in a multiethnic New York City birth cohort. Cancer Epidemiol Biomarkers Prev. 2008; 17, 2306–2310.CrossRefGoogle Scholar
15. Flom, JD, Ferris, JS, Liao, Y, et al. . Prenatal smoke exposure and genomic DNA methylation in a multiethnic birth cohort. Cancer Epidemiol Biomarkers Prev. 2011; 20, 2518–2523.CrossRefGoogle Scholar
16. Toledo-Rodriguez, M, Lotfipour, S, Leonard, G, et al. . Maternal smoking during pregnancy is associated with epigenetic modifications of the brain-derived neurotrophic factor-6 exon in adolescent offspring. Am J Med Genet B Neuropsychiatr Genet. 2010; 153, 1350–1354.CrossRefGoogle Scholar
17. Suter, M, MA, J, Harris, A, et al. . Maternal tobacco use modestly alters correlated epigenome-wide placental DNA methylation and gene expression. Epigenetics. 2011; 6, 1284–1294.CrossRefGoogle ScholarPubMed
18. Desai, S, Alva, S. Maternal education and child health: is there a strong causal relationship? Demography. 1998; 35, 71–81.CrossRefGoogle Scholar
19. Borghol, N, Suderman, M, McArdle, W, et al. . Associations with early-life socio-economic position in adult DNA methylation. Int J Epidemiol. 2012; 41, 62–74.CrossRefGoogle ScholarPubMed
20. Steegers-Theunissen, RP, Obermann-Borst, SA, Kremer, D, et al. . Periconceptional maternal folic acid use of 400 μg per day is related to increased methylation of the IGF2 gene in the very young child. PLoS One. 2009, e7845.CrossRefGoogle Scholar
21. Coolen, MW, Statham, AL, Gardiner-Garden, M, Clark, SJ. Genomic profiling of CpG methylation and allelic specificity using quantitative high-throughput mass spectrometry: critical evaluation and improvements. Nucleic Acids Res. 2007; 35, e119.CrossRefGoogle ScholarPubMed
22. Talens, RP, Boomsma, DI, Tobi, EW, et al. . Variation, patterns, and temporal stability of DNA methylation: considerations for epigenetic epidemiology. FASEB J. 2010; 24, 3135–3144.CrossRefGoogle ScholarPubMed
23. Murphy, SK, Adigun, A, Huang, Z, et al. . Gender-specific methylation differences in relation to prenatal exposure to cigarette smoke. Gene. 2012; 494, 36–43.CrossRefGoogle ScholarPubMed
24. Li, YF, Langholz, B, Salam, MT, Gilliland, FD. Maternal and grandmaternal smoking patterns are associated with early childhood asthma. Chest. 2005; 127, 1232–1241.Google ScholarPubMed
25. Breitling, LP, Yang, R, Korn, B, Burwinkel, B, Brenner, H. Tobacco-smoking-related differential DNA methylation: 27 K discovery and replication. Am J Hum Genet. 2011; 88, 450–457.CrossRefGoogle Scholar