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Maternal pelvic size, fetal growth and risk of stroke in adult offspring in a large Swedish cohort

Published online by Cambridge University Press:  06 October 2015

A. Heshmati ,
M. P. Chaparro  and
I. Koupil
A. Heshmati*
Affiliation:
Centre for Health Equity Studies (CHESS), Stockholm University/Karolinska Institutet, Stockholm, Sweden
M. P. Chaparro
Affiliation:
Centre for Health Equity Studies (CHESS), Stockholm University/Karolinska Institutet, Stockholm, Sweden
I. Koupil
Affiliation:
Centre for Health Equity Studies (CHESS), Stockholm University/Karolinska Institutet, Stockholm, Sweden Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden
*
*Address for correspondence: A. Heshmati, Centre for Health Equity Studies (CHESS), Stockholm University/Karolinska Institutet, Sveavägen 160, Floor 5, 10691 Stockholm, Sweden. (Email [email protected])
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Abstract

Earlier research suggests that maternal pelvic size is associated with offspring’s stroke risk in later life. We followed 6362 men and women from Uppsala, Sweden, born between 1915 and 1929 from 1964 to 2008 to assess whether maternal pelvic size was associated with incidence of thrombotic stroke (TS), haemorrhagic stroke (HS) and other stroke (OS). Offspring whose mothers had a flat pelvis had lower birth weight and birth-weight-for-gestational-age compared with those who did not. Inverse linear associations of birth-weight-for-gestational-age were observed with TS and OS. Female offspring whose mothers had a flat pelvis had increased risk of TS, but flat pelvis was not associated with other types of stroke. A smaller difference between intercristal and interspinous diameters and a smaller external conjugate diameter were independently associated with HS, whereas no pelvic measurements were associated with OS. We conclude that a smaller pelvis in women may impact the health of their offspring in adulthood.

Keywords

childhood social classfetal growthpelvic sizestroke
Type
Brief Report
Information
Journal of Developmental Origins of Health and Disease , Volume 7 , Supplement 1: Themed Issue: The Gut Microbiome and Immunity: How it is Shaped by Early Life , February 2016 , pp. 108 - 113
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Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2015 

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