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Is low birth weight an additional risk factor for hypertension in paediatric patients after kidney transplantation?

Published online by Cambridge University Press:  16 August 2019

Larissa Badim Santos ,
Luana Meireles Borges ,
Livia Victorino Souza ,
Claudia Rosso Felipe ,
José Osmar Medina-Pestana  and
Maria do Carmo Franco Open the ORCID record for Maria do Carmo Franco [Opens in a new window]
Larissa Badim Santos
Affiliation:
Department of Medicine, Nephrology Division, School of Medicine, Federal University of São Paulo, São Paulo, Brazil
Luana Meireles Borges
Affiliation:
Department of Medicine, Nephrology Division, School of Medicine, Federal University of São Paulo, São Paulo, Brazil
Livia Victorino Souza
Affiliation:
Department of Medicine, Nephrology Division, School of Medicine, Federal University of São Paulo, São Paulo, Brazil
Claudia Rosso Felipe
Affiliation:
Department of Medicine, Nephrology Division, School of Medicine, Federal University of São Paulo, São Paulo, Brazil
José Osmar Medina-Pestana
Affiliation:
Department of Medicine, Nephrology Division, School of Medicine, Federal University of São Paulo, São Paulo, Brazil
Maria do Carmo Franco*
Affiliation:
Department of Medicine, Nephrology Division, School of Medicine, Federal University of São Paulo, São Paulo, Brazil
*
Address for correspondence: Maria do Carmo Franco, Division of Nephrology, School of Medicine, Laboratory of Translational Research in Vascular and Molecular Physiology, Federal University of São Paulo, Rua Botucatu, 862-São Paulo, SP, Brazil. Email: [email protected]
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Abstract

Hypertension (HTN) remains a common complication after kidney transplantation among paediatric patients. Although low birth weight (LBW) has been implicated as an important risk factor for cardiovascular diseases, its effect on transplantation patients has not yet been addressed. It is essential to determine whether children with LBW who undergo transplantation are more likely to develop post-transplantation HTN. For this study, the medical records of 96 kidney recipients were retrospectively examined. A total of 83 patients fulfilled the inclusion criteria. Overall, post-transplantation HTN was observed in 54% of the recipients. Multivariate logistic regression revealed that time from transplantation >14 months (odds ratio (OR) 3.6; 95% confidence interval (CI) 1.31–10.06; P = 0.013), current CKD (OR 2.6; 95% CI 1.01–7.20; P = 0.045), presence of LBW (OR 3.6; 95% CI 1.04–12.32; P = 0.044) and current overweight/obesity (OR 3.7; 95% CI 1.02–13.91; P = 0.047) were associated with post-transplantation HTN. In conclusion, our data provide evidence for the first time that LBW is a significant predictive factor in the development of post-transplantation HTN. This finding has important clinical implications as it serves to alert clinicians about this additional risk factor in paediatric patients undergoing kidney transplant.

Keywords

Low birth weightpost-transplantation hypertensionkidney transplantchildren
Type
Brief Report
Information
Journal of Developmental Origins of Health and Disease , Volume 11 , Issue 1 , February 2020 , pp. 3 - 6
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2019 

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