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Intrauterine growth restriction combined with a maternal high-fat diet increased adiposity and serum corticosterone levels in adult rat offspring

Part of: Liggins Institute, New Zealand and the Japanese DOHaD Society

Published online by Cambridge University Press:  05 February 2018

E. K. Zinkhan Open the ORCID record for E. K. Zinkhan [Opens in a new window] ,
B. Yu ,
C. W. Callaway  and
R. A. McKnight
E. K. Zinkhan*
Affiliation:
Department of Pediatrics, Division of Neonatology, University of Utah, Salt Lake City, UT, USA
B. Yu
Affiliation:
Department of Pediatrics, Division of Neonatology, University of Utah, Salt Lake City, UT, USA
C. W. Callaway
Affiliation:
Department of Pediatrics, Division of Neonatology, University of Utah, Salt Lake City, UT, USA
R. A. McKnight
Affiliation:
Department of Pediatrics, Division of Neonatology, University of Utah, Salt Lake City, UT, USA
*
*Author for correspondence: E. K. Zinkhan, Department of Pediatrics, Division of Neonatology, University of Utah, 295 Chipeta Way, Salt Lake City, UT 84108, USA. E-mail [email protected]
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Abstract

Intrauterine growth restriction (IUGR) and fetal exposure to a maternal high-fat diet (HFD) independently increase the risk of developing obesity in adulthood. Excess glucocorticoids increase obesity. We hypothesized that surgically induced IUGR combined with an HFD would increase adiposity and glucocorticoids more than in non-IUGR offspring combined with the same HFD, findings that would persist despite weaning to a regular diet. Non-IUGR (N) and IUGR (I) rat offspring from dams fed either regular rat chow (R) or an HFD (H) were weaned to either a regular rat chow or an HFD. For non-IUGR and IUGR rats, this study design resulted in three diet groups: offspring from dams fed a regular diet and weaned to a regular diet (NRR and IRR), offspring rats from dams fed an HFD and weaned to a regular diet (NHR and IHR) and offspring from dams fed an HFD and weaned to an HFD (NHH and IHH). Magnetic resonance imaging or fasting visceral and subcutaneous adipose tissue collection occurred at postnatal day 60. IHH male rats had greater adiposity than NHH males, findings that were only partly normalized by weaning to a regular chow. IHH male rats had a 10-fold increase in serum corticosterone levels. IHH female rats had increased adiposity and serum triglycerides. We conclude that IUGR combined with an HFD throughout life increased adiposity, glucocorticoids and triglycerides in a sex-specific manner. Our data suggest that one mechanism through which the perinatal environment programs increased adiposity in IHH male rats may be via increased systemic glucocorticoids.

Keywords

glucocorticoidglucocorticoid receptorhigh-fat dietintrauterine growth restrictionobesity
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 9 , Issue 3: Themed Issue: NZ-Japan , June 2018 , pp. 315 - 328
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2018 

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