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Impact of prenatal and postnatal maternal environment on nephron endowment, renal function and blood pressure in the Lewis polycystic kidney rat

Published online by Cambridge University Press:  02 October 2018

A. Ding ,
S. L. Walton ,
K. M. Moritz  and
J. K. Phillips Open the ORCID record for J. K. Phillips [Opens in a new window]
A. Ding
Affiliation:
Department of Biomedical Science, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia
S. L. Walton
Affiliation:
School of Biomedical Sciences, University of Queensland, St Lucia, QLD, Australia
K. M. Moritz
Affiliation:
School of Biomedical Sciences, University of Queensland, St Lucia, QLD, Australia Child Health Research Centre, University of Queensland, St Lucia, QLD, Australia
J. K. Phillips*
Affiliation:
Department of Biomedical Science, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia
*
*Address for correspondence:J. K. Phillips, Department of Biomedical Science, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia. E-mail: [email protected]
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Abstract

Maternal insufficiency during fetal development can have long-lasting effects on the offspring, most notably on nephron endowment. In polycystic kidney disease (PKD), variability in severity of disease is observed and maternal environment may be a modifying factor. In this study, we first established that in a rodent model of PKD, the Lewis polycystic kidney (LPK) rat’s nephron numbers are 25% lower compared with wildtype animals. We then investigated the effects of prenatal and postnatal maternal environment on phenotype and nephron number. LPK pups born from and raised by homozygous LPK dams (control) were compared with LPK pups cross-fostered onto heterozygous LPK dams to improve postnatal environment; with LPK pups born from and raised by heterozygous LPK dams to improve both prenatal and postnatal environment and with LPK pups born from and raised by Wistar Kyoto-LPK heterozygous dams to improve both prenatal and postnatal environment on a different genetic background. Improvement in both prenatal and postnatal environment improved postnatal growth, renal function and reduced blood pressure, most notably in animals with different genetic background. Animals with improved postnatal environment only showed improved growth and blood pressure, but to a lesser extent. All intervention groups showed increased nephron number compared with control LPK. In summary, prenatal and postnatal environment had significant effect in delaying progression and reducing severity of PKD, including nephron endowment.

Keywords

blood pressurebody weightmaternal environmentnephron endowmentpolycystic kidney disease
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 10 , Issue 2 , April 2019 , pp. 154 - 163
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2018. 

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