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Impact of Leuconostoc SD23 intake in obese pregnant rats: benefits for maternal metabolism

Part of: DOHaD Research in Latin-American

Published online by Cambridge University Press:  19 May 2020

Diana C. Castro-Rodríguez Open the ORCID record for Diana C. Castro-Rodríguez [Opens in a new window] ,
Gimena Juárez-Pilares ,
Luz Cano-Cano ,
Mariana Pérez-Sánchez ,
Carlos A. Ibáñez Open the ORCID record for Carlos A. Ibáñez [Opens in a new window] ,
Luis A. Reyes-Castro Open the ORCID record for Luis A. Reyes-Castro [Opens in a new window] ,
Jorge Yáñez-Fernández Open the ORCID record for Jorge Yáñez-Fernández [Opens in a new window]  and
Elena Zambrano Open the ORCID record for Elena Zambrano [Opens in a new window]
Diana C. Castro-Rodríguez
Affiliation:
Reproductive Biology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico CONACYT-Cátedras, Reproductive Biology Department, Instituto Nacional de Ciencias Médicas y Nutrición SZ, Mexico City, Mexico
Gimena Juárez-Pilares
Affiliation:
Reproductive Biology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Luz Cano-Cano
Affiliation:
Reproductive Biology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Mariana Pérez-Sánchez
Affiliation:
Reproductive Biology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Carlos A. Ibáñez
Affiliation:
Reproductive Biology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Luis A. Reyes-Castro
Affiliation:
Reproductive Biology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Jorge Yáñez-Fernández
Affiliation:
Bioprocess Department, Unidad Profesional Interdisciplinaria de Biotecnología (UPIBI), Instituto Politécnico Nacional (IPN), Mexico City, Mexico
Elena Zambrano*
Affiliation:
Reproductive Biology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
*
Address for correspondence: Elena Zambrano, Reproductive Biology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico. Email: [email protected]
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Abstract

Maternal obesity (MO) during pregnancy and lactation leads to maternal and offspring metabolic dysfunction. Recent research has suggested that probiotics might be a novel approach to counteract these unwanted MO effects. The aim of this research was to analyze the impact of Leuconostoc SD23, a probiotic isolated from aguamiel (traditional Mexican drink), on MO metabolism in rats at the end of lactation (21 days). From weaning through lactation, control female Wistar rats (C) ate chow (5% fat) or high-energy obesogenic diet (MO; 25% fat). Half the C and MO mothers received a daily dose (1 × 1010 CFU/ml) of probiotic orally, control with probiotic (CP) and MO with probiotic (MOP), 1 month before mating and through pregnancy and lactation. Histological analyses of the liver, white adipose tissue and small intestine, body composition, glucose, insulin, triglycerides, and leptin were determined in mothers at the end of lactation. Maternal weight during pregnancy was greater in MO than C mothers, but similar at the end of lactation. Probiotic intervention had no effect on maternal weight. However, at the end of lactation, percentage of body fat was higher in MO than C, CP, and MOP. Serum glucose, homeostasis model assessment of insulin resistance, and triglycerides were higher in MO versus C, CP, and MOP. MO small intestine villus height was higher versus MOP, C, and CP. Leuconostoc SD23 did not present adverse effects in C. Conclusions: maternal administration of Leuconostoc SD23 has beneficial effects on maternal metabolism, which holds possibilities for preventing adverse offspring metabolic programming.

Keywords

ProbioticsobesityprogrammingAgave salmianaaguamiel
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 11 , Issue 5 , October 2020 , pp. 533 - 539
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2020

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