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Further evidence of the developmental origins of osteoarthritis: results from the Hertfordshire Cohort Study

Published online by Cambridge University Press:  22 August 2014

M. A. Clynes ,
C. Parsons ,
M. H. Edwards ,
K. A. Jameson ,
N. C. Harvey ,
A. Aihie Sayer ,
C. Cooper  and
E. M. Dennison
M. A. Clynes*
Affiliation:
MRC Lifecourse Epidemiology Unit, University of Southampton, UK
C. Parsons
Affiliation:
MRC Lifecourse Epidemiology Unit, University of Southampton, UK
M. H. Edwards
Affiliation:
MRC Lifecourse Epidemiology Unit, University of Southampton, UK
K. A. Jameson
Affiliation:
MRC Lifecourse Epidemiology Unit, University of Southampton, UK
N. C. Harvey
Affiliation:
MRC Lifecourse Epidemiology Unit, University of Southampton, UK
A. Aihie Sayer
Affiliation:
MRC Lifecourse Epidemiology Unit, University of Southampton, UK
C. Cooper
Affiliation:
MRC Lifecourse Epidemiology Unit, University of Southampton, UK NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, UK
E. M. Dennison
Affiliation:
MRC Lifecourse Epidemiology Unit, University of Southampton, UK
*
*Address for Correspondence: Dr M. A. Clynes, Southampton General Hospital, Tremona Road, Southampton, Hampshire SO16 6YD, UK.(Email [email protected])
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Abstract

Investigators have suggested a link between birth weight and both hand and lumbar spine osteoarthritis (OA). In this study, we sought to extend these observations by investigating relationships between growth in early life, and clinical and radiological diagnoses of OA at the hand, knee and hip, among participants from the Hertfordshire Cohort Study. Data were available for 222 men and 222 women. Clinical OA was defined based on American College of Rheumatology criteria. Radiographs were taken of the knees and hips, and graded for the presence of osteophytes and overall Kellgren and Lawrence (KL) score. Lower weight at year one was associated with higher rates of clinical hand OA (OR 1.396, 95% CI 1.05, 1.85, P=0.021). Individuals with lower birth weights were more likely to have hip osteophytes (OR 1.512, 95% CI 1.14, 2.00, P=0.004) and this remained robust after adjustment for confounders. Furthermore, a low weight at one year was also associated with a higher osteophyte number in the lateral compartment of the knee, after adjustment for confounders (OR 1.388, 95% CI 1.01, 1.91, P=0.043). We have found further evidence of a relationship between early life factors and adult OA. These findings accord with previous studies.

Keywords

birth weightboneosteoarthritisprogramming
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 5 , Issue 6 , December 2014 , pp. 453 - 458
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2014 

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