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Environmental contaminants and child’s growth

Published online by Cambridge University Press:  05 February 2019

M. Kadawathagedara*
Affiliation:
INSERM, UMR1153 Centre of Research in Epidemiology and Statistics Sorbonne Paris Cité, Team “Early Origin of the Child’s Health and Development” (ORCHAD), Paris Descartes University, Paris, France
B. de Lauzon-Guillain
Affiliation:
INSERM, UMR1153 Centre of Research in Epidemiology and Statistics Sorbonne Paris Cité, Team “Early Origin of the Child’s Health and Development” (ORCHAD), Paris Descartes University, Paris, France
J. Botton
Affiliation:
INSERM, UMR1153 Centre of Research in Epidemiology and Statistics Sorbonne Paris Cité, Team “Early Origin of the Child’s Health and Development” (ORCHAD), Paris Descartes University, Paris, France Faculty of Pharmacy, Université Paris-Sud, Université Paris-Saclay, Châtenay-Malabry, France
*
*Address for correspondence: M. Kadawathagedara, INSERM UMR 1153, Equipe Orchad, 16 Avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France. E-mail: [email protected]

Abstract

Experimental data have suggested that some contaminants in the environment may increase the risk of obesity. Infants can be exposed to chemicals either prenatally, by trans-placental passage of chemicals, or postnatally by their own diet and by other external pathways (air inhalation, dust, hand-to-mouth exposure) after birth. To provide a review of epidemiological evidence on the association between prenatal exposure to chemicals and prenatal and postnatal growth, we present the literature from systematic review articles and international meta-analyses, when available, or recent research articles when summarizing articles were not available. The most studied contaminants in this field were persistent organic pollutants (e.g. organochlorinated pesticides, polychlorinated biphenyls), non-persistent pollutants (e.g. phthalates, bisphenol A), toxic heavy metals (i.e. cadmium, lead and mercury), arsenic, mycotoxins and acrylamide. Mounting evidence suggests that child’s growth may be associated with prenatal or postnatal exposures to environmental contaminants. Improving exposure assessment and studying the contaminants as mixtures should allow to gain knowledge about the environmental determinants of growth and obesity.

Type
Review
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2018 

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References

1. Giaginis, C, Theocharis, S, Tsantili-Kakoulidou, A. Current toxicological aspects on drug and chemical transport and metabolism across the human placental barrier. Expert Opin Drug Metab Toxicol. 2012; 8, 12631275.Google Scholar
2. Myren, M, Mose, T, Mathiesen, L, Knudsen, LE. The human placenta – an alternative for studying foetal exposure. Toxicol In Vitro. 2007; 21, 13321340.Google Scholar
3. Landrigan, P, Garg, A, Droller, DB. Assessing the effects of endocrine disruptors in the National Children’s Study. Environ Health Perspect. 2003; 111, 16781682.Google Scholar
4. Barouki, R, Gluckman, PD, Grandjean, P, Hanson, M, Heindel, JJ. Developmental origins of non-communicable disease: implications for research and public health. Environ Health. 2012; 11, 4251.Google Scholar
5. Liu, SH, Bobb, JF, Lee, KH, et al. Lagged kernel machine regression for identifying time windows of susceptibility to exposures of complex mixtures. Biostatistics. 2018; 19, 325341.Google Scholar
6. Nowakowski, RS, Hayes, NL. CNS development: an overview. Dev Psychopathol. 1999; 11, 395417.Google Scholar
7. Schoeters, GE, Den Hond, E, Koppen, G, et al. Biomonitoring and biomarkers to unravel the risks from prenatal environmental exposures for later health outcomes. Am J Clin Nutr. 2011; 94(Suppl. 6), 1964S1969SS.Google Scholar
8. Slama, R, Cordier, S. [Impact of chemical and physical environmental factors on the course and outcome of pregnancy]. J Gynecol Obstet Biol Reprod. 2013; 42, 413444.Google Scholar
9. Wigle, DT, Arbuckle, TE, Turner, MC, et al. Epidemiologic evidence of relationships between reproductive and child health outcomes and environmental chemical contaminants. J Toxicol Environ Health B Crit Rev. 2008; 11, 373517.Google Scholar
10. Stockholm Convention. Stockholm Convention on Persistent Organic Polluants. 2001. United Nations Environment Programme (UNEP): Stocklholm.Google Scholar
11. Magliano, DJ, Loh, VH, Harding, JL, Botton, J, Shaw, JE. Persistent organic pollutants and diabetes: a review of the epidemiological evidence. Diabetes Metab. 2014; 40, 114.Google Scholar
12. Giesy, JP, Kannan, K. Dioxin-like and non-dioxin-like toxic effects of polychlorinated biphenyls (PCBs): implications for risk assessment. Crit Rev Toxicol. 1998; 28, 511569.Google Scholar
13. Agency for Toxic Substances and Disease Registry. Toxicological Profile for Polychorinated biphenyls (PCBs). 2000. Public Health Service: Atlanta, GA.Google Scholar
14. IARC. IARC Monogrpahs on the Evaluation of Carcinogenic Risks to Humans: Polychlorinated Biphenyls and Polybrominated Biphenyls. 2016. IARC: Lyon.Google Scholar
15. Lu, YC, Wong, PN. PCB poisoning in Japan and Taiwan. Dermatological, medical, and laboratory findings of patients in Taiwan and their treatments. Prog Clin Biol Res. 1984; 137, 81115.Google Scholar
16. Chen, YC, Yu, ML, Rogan, WJ, Gladen, BC, Hsu, CC. A 6-year follow-up of behavior and activity disorders in the Taiwan Yu-cheng children. Am J public Health. 1994; 84, 415421.Google Scholar
17. Jacobson, JL, Jacobson, SW, Humphrey, HE. Effects of in utero exposure to polychlorinated biphenyls and related contaminants on cognitive functioning in young children. J Pediatr. 1990; 116, 3845.Google Scholar
18. Govarts, E, Nieuwenhuijsen, M, Schoeters, G, et al. Birth weight and prenatal exposure to polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (DDE): a meta-analysis within 12 European birth cohorts. Environ Health Perspect. 2012; 120, 162170.Google Scholar
19. El Majidi, N, Bouchard, M, Gosselin, NH, Carrier, G. Relationship between prenatal exposure to polychlorinated biphenyls and birth weight: a systematic analysis of published epidemiological studies through a standardization of biomonitoring data. Regul Toxicol Pharmacol. 2012; 64, 161176.Google Scholar
20. Iszatt, N, Stigum, H, Verner, MA, et al. Prenatal and postnatal exposure to persistent organic pollutants and infant growth: a pooled analysis of seven European birth cohorts. Environ Health Perspect. 2015; 123, 730736.Google Scholar
21. IARC IARC Monographs on the evaluation of carcinogenic risks to humans: 2,3,7,8-TCDD, 2,3,4,7,8-PeCDF, PCB 126. 1987. IARC: Lyon.Google Scholar
22. IARC. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. 1995. IARC: Lyon.Google Scholar
23. Leung, HW, Kerger, BD, Paustenbach, DJ. Elimination half-lives of selected polychlorinated dibenzodioxins and dibenzofurans in breast-fed human infants. J Toxicol Environ Health A. 2006; 69, 437443.Google Scholar
24. Pan, X, Liu, X, Li, X, et al. Association between environmental dioxin-related toxicants exposure and adverse pregnancy outcome: systematic review and meta-analysis. Int J Fertil Steril. 2015; 8, 351366.Google Scholar
25. Iszatt, N, Stigum, H, Govarts, E, et al. Perinatal exposure to dioxins and dioxin-like compounds and infant growth and body mass index at seven years: a pooled analysis of three European birth cohorts. Environ Int. 2016; 94, 399407.Google Scholar
26. Agency for Toxic Substances and Disease Registry. Toxicological Profile for DDT, DDE, and DDD. 2002. Public Health Service: Atlanta, GA.Google Scholar
27. AMAP AMaAPA. AMAP Assessment 2009: Human Health in the Artic. 2009. Arctic Monitoring and Assessment Programme (AMAP): Oslo.Google Scholar
28. ATSDR. Toxicological Profile for DDT, DDE, and DDD. 2002. Public Health Service: Atlanta, GA.Google Scholar
29. Longnecker, MP, Klebanoff, MA, Zhou, H, Brock, JW. Association between maternal serum concentration of the DDT metabolite DDE and preterm and small-for-gestational-age babies at birth. Lancet. 2001; 358, 110114.Google Scholar
30. Rogan, WJ, Gladen, BC, McKinney, JD, et al. Polychlorinated biphenyls (PCBs) and dichlorodiphenyl dichloroethene (DDE) in human milk: effects of maternal factors and previous lactation. Am J Public Health. 1986; 76, 172177.Google Scholar
31. Siddiqui, MK, Srivastava, S, Srivastava, SP, et al. Persistent chlorinated pesticides and intra-uterine foetal growth retardation: a possible association. Int Arch Occup Environ Health. 2003; 76, 7580.Google Scholar
32. Weisskopf, MG, Anderson, HA, Hanrahan, LP, et al. Maternal exposure to Great Lakes sport-caught fish and dichlorodiphenyl dichloroethylene, but not polychlorinated biphenyls, is associated with reduced birth weight. Environ Res. 2005; 97, 149162.Google Scholar
33. Bjerregaard, P, Hansen, JC. Organochlorines and heavy metals in pregnant women from the Disko Bay area in Greenland. Sci Total Environ. 2000; 245, 195202.Google Scholar
34. Dewailly, E, Ayotte, P, Bruneau, S, et al. Inuit exposure to organochlorines through the aquatic food chain in arctic Quebec. Environ Health Perspect. 1993; 101, 618620.Google Scholar
35. Farhang, L, Weintraub, JM, Petreas, M, Eskenazi, B, Bhatia, R. Association of DDT and DDE with birth weight and length of gestation in the Child Health and Development Studies, 1959–1967. Am J Epidemiol. 2005; 162, 717725.Google Scholar
36. Gladen, BC, Shkiryak-Nyzhnyk, ZA, Chyslovska, N, Zadorozhnaja, TD, Little, RE. Persistent organochlorine compounds and birth weight. Ann Epidemiol. 2003; 13, 151157.Google Scholar
37. Karmaus, W, Zhu, X. Maternal concentration of polychlorinated biphenyls and dichlorodiphenyl dichlorethylene and birth weight in Michigan fish eaters: a cohort study. Environ Health. 2004; 3, 19.Google Scholar
38. Ribas-Fito, N, Sala, M, Cardo, E, et al. Association of hexachlorobenzene and other organochlorine compounds with anthropometric measures at birth. Pediatr Res. 2002; 52, 163167.Google Scholar
39. Rogan, WJ, Gladen, BC, McKinney, JD, et al. Neonatal effects of transplacental exposure to PCBs and DDE. J Pediatr. 1986; 109, 335341.Google Scholar
40. Agency for Toxic Substances and Disease Registry. Toxicological Profile for Hexachlorobenzene. 2015. Public Health Service: Atlanta, GA.Google Scholar
41. Guo, H, Jin, Y, Cheng, Y, et al. Prenatal exposure to organochlorine pesticides and infant birth weight in China. Chemosphere. 2014; 110, 17.Google Scholar
42. Lopez-Espinosa, MJ, Murcia, M, Iniguez, C, et al. Prenatal exposure to organochlorine compounds and birth size. Pediatrics. 2011; 128, e127e134.Google Scholar
43. Vafeiadi, M, Vrijheid, M, Fthenou, E, et al. Persistent organic pollutants exposure during pregnancy, maternal gestational weight gain, and birth outcomes in the mother–child cohort in Crete, Greece (RHEA study). Environ Int. 2014; 64, 116123.Google Scholar
44. Fenster, L, Eskenazi, B, Anderson, M, et al. Association of in utero organochlorine pesticide exposure and fetal growth and length of gestation in an agricultural population. Environ Health Perspect. 2006; 114, 597602.Google Scholar
45. Sagiv, SK, Tolbert, PE, Altshul, LM, Korrick, SA. Organochlorine exposures during pregnancy and infant size at birth. Epidemiology. 2007; 18, 120129.Google Scholar
46. Tang-Peronard, JL, Andersen, HR, Jensen, TK, Heitmann, BL. Endocrine-disrupting chemicals and obesity development in humans: a review. Obes Rev. 2011; 12, 622636.Google Scholar
47. Smink, A, Ribas-Fito, N, Garcia, R, et al. Exposure to hexachlorobenzene during pregnancy increases the risk of overweight in children aged 6 years. Acta Paediatr. 2008; 97, 14651469.Google Scholar
48. Valvi, D, Mendez, MA, Garcia-Esteban, R, et al. Prenatal exposure to persistent organic pollutants and rapid weight gain and overweight in infancy. Obesity (Silver Spring). 2014; 22, 488496.Google Scholar
49. Verhulst, SL, Nelen, V, Hond, ED, et al. Intrauterine exposure to environmental pollutants and body mass index during the first 3 years of life. Environ Health Perspect. 2009; 117, 122126.Google Scholar
50. Agency for Toxic Substances and Disease Registry. Toxicological Profile for Polubrominated Diphenyl Ethers (PBDEs). 2017. Public Health Service: Atlanta, GA.Google Scholar
51. Zheng, T, Zhang, J, Sommer, K, et al. Effects of environmental exposures on fetal and childhood growth trajectories. Ann Glob Health. 2016; 82, 4199.Google Scholar
52. Chao, HR, Wang, SL, Lee, WJ, Wang, YF, Papke, O. Levels of polybrominated diphenyl ethers (PBDEs) in breast milk from central Taiwan and their relation to infant birth outcome and maternal menstruation effects. Environ Int. 2007; 33, 239245.Google Scholar
53. Harley, KG, Chevrier, J, Aguilar Schall, R, et al. Association of prenatal exposure to polybrominated diphenyl ethers and infant birth weight. Am J Epidemiol. 2011; 174, 885892.Google Scholar
54. Wu, K, Xu, X, Liu, J, et al. Polybrominated diphenyl ethers in umbilical cord blood and relevant factors in neonates from Guiyu, China. Environ Sci Technol. 2010; 44, 813819.Google Scholar
55. Mazdai, A, Dodder, NG, Abernathy, MP, Hites, RA, Bigsby, RM. Polybrominated diphenyl ethers in maternal and fetal blood samples. Environ Health Perspect. 2003; 111, 12491252.Google Scholar
56. Tan, J, Loganath, A, Chong, YS, Obbard, JP. Exposure to persistent organic pollutants in utero and related maternal characteristics on birth outcomes: a multivariate data analysis approach. Chemosphere. 2009; 74, 428433.Google Scholar
57. Vrijheid, M, Casas, M, Gascon, M, Valvi, D, Nieuwenhuijsen, M. Environmental pollutants and child health – a review of recent concerns. Int J Hyg Environ Health. 2016; 219, 331342.Google Scholar
58. Agency for Toxic Substances and Disease Registry. Draft, Toxicological Profile Perfluoroalkyls. 2015. Public Health Service: Atlanta, GA.Google Scholar
59. Lindstrom, AB, Strynar, MJ, Libelo, EL. Polyfluorinated compounds: past, present, and future. Environ Sci Technol. 2011; 45, 79547961.Google Scholar
60. Olsen, GW, Burris, JM, Ehresman, DJ, et al. Half-life of serum elimination of perfluorooctanesulfonate,perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers. Environ Health Perspect. 2007; 115, 12981305.Google Scholar
61. Fromme, H, Tittlemier, SA, Volkel, W, Wilhelm, M, Twardella, D. Perfluorinated compounds – exposure assessment for the general population in Western countries. Int J Hyg Environ Health. 2009; 212, 239270.Google Scholar
62. Haug, LS, Huber, S, Becher, G, Thomsen, C. Characterisation of human exposure pathways to perfluorinated compounds – comparing exposure estimates with biomarkers of exposure. Environ Int. 2011; 37, 687693.Google Scholar
63. Bach, CC, Bech, BH, Brix, N, et al. Perfluoroalkyl and polyfluoroalkyl substances and human fetal growth: a systematic review. Crit Rev Toxicol. 2015; 45, 5367.Google Scholar
64. Johnson, PI, Sutton, P, Atchley, DS, et al. The Navigation Guide – evidence-based medicine meets environmental health: systematic review of human evidence for PFOA effects on fetal growth. Environ Health Perspect. 2014; 122, 10281039.Google Scholar
65. Andersen, CS, Fei, C, Gamborg, M, et al. Prenatal exposures to perfluorinated chemicals and anthropometric measures in infancy. Am J Epidemiol. 2010; 172, 12301237.Google Scholar
66. Andersen, CS, Fei, C, Gamborg, M, et al. Prenatal exposures to perfluorinated chemicals and anthropometry at 7 years of age. Am J Epidemiol. 2013; 178, 921927.Google Scholar
67. Maisonet, M, Terrell, ML, McGeehin, MA, et al. Maternal concentrations of polyfluoroalkyl compounds during pregnancy and fetal and postnatal growth in British girls. Environ Health Perspect. 2012; 120, 14321437.Google Scholar
68. Philippat, C, Botton, J, Calafat, AM, et al. Prenatal exposure to phenols and growth in boys. Epidemiology. 2014; 25, 625635.Google Scholar
69. Agency for Toxic Substances and Disease Registry. Toxicological Profile for Di(2-ethylhexyl)phthalate (DEHP). 2002. Public Health Service: Atlanta, GA.Google Scholar
70. Hauser, R, Duty, S, Godfrey-Bailey, L, Calafat, AM. Medications as a source of human exposure to phthalates. Environ Health Perspect. 2004; 112, 751753.Google Scholar
71. ATSDR. Toxicological Profile for Di(2-ethylhexyl)phthalate (DEHP). 2002. Public Health Service: Atlanta, GA.Google Scholar
72. Blount, BC, Silva, MJ, Caudill, SP, et al. Levels of seven urinary phthalate metabolites in a human reference population. Environ Health Perspect. 2000; 108, 979982.Google Scholar
73. Marie, C, Vendittelli, F, Sauvant-Rochat, MP. Obstetrical outcomes and biomarkers to assess exposure to phthalates: a review. Environ Int. 2015; 83, 116136.Google Scholar
74. Braun, JM. Early-life exposure to EDCs: role in childhood obesity and neurodevelopment. Nat Rev Endocrinol. 2017; 13, 161173.Google Scholar
75. Valvi, D, Casas, M, Romaguera, D, et al. Prenatal phthalate exposure and childhood growth and blood pressure: evidence from the Spanish INMA-Sabadell birth cohort study. Environ Health Perspect. 2015; 123, 10221029.Google Scholar
76. Maresca, MM, Hoepner, LA, Hassoun, A, et al. Prenatal exposure to phthalates and childhood body size in an urban cohort. Environ Health Perspect. 2016; 124, 514520.Google Scholar
77. Buckley, JP, Engel, SM, Braun, JM, et al. Prenatal phthalate exposures and body mass index among 4- to 7-year-old children: a pooled analysis. Epidemiology. 2016; 27, 449458.Google Scholar
78. Botton, J, Philippat, C, Calafat, AM, et al. Phthalate pregnancy exposure and male offspring growth from the intra-uterine period to five years of age. Environ Res. 2016; 151, 601609.Google Scholar
79. Agay-Shay, K, Martinez, D, Valvi, D, et al. Exposure to endocrine-disrupting chemicals during pregnancy and weight at 7 years of age: a multi-pollutant approach. Environ Health Perspect. 2015; 123, 10301037.Google Scholar
80. Le, HH, Carlson, EM, Chua, JP, Belcher, SM. Bisphenol A is released from polycarbonate drinking bottles and mimics the neurotoxic actions of estrogen in developing cerebellar neurons. Toxicol Lett. 2008; 176, 149156.Google Scholar
81. Munguia-Lopez, EM, Gerardo-Lugo, S, Peralta, E, Bolumen, S, Soto-Valdez, H. Migration of bisphenol A (BPA) from can coatings into a fatty-food simulant and tuna fish. Food Addit Contam. 2005; 22, 892898.Google Scholar
82. Geens, T, Aerts, D, Berthot, C, et al. A review of dietary and non-dietary exposure to bisphenol-A. Food Chem Toxicol. 2012; 50, 37253740.Google Scholar
83. Vandenberg, LN, Hauser, R, Marcus, M, Olea, N, Welshons, WV. Human exposure to bisphenol A (BPA). Reprod Toxicol. 2007; 24, 139177.Google Scholar
84. Rochester, JR. Bisphenol A and human health: a review of the literature. Reprod Toxicol. 2013; 42, 132155.Google Scholar
85. Snijder, CA, Heederik, D, Pierik, FH, et al. Fetal growth and prenatal exposure to bisphenol A: the generation R study. Environ Health Perspect. 2013; 121, 393398.Google Scholar
86. Bhandari, R, Xiao, J, Shankar, A. Urinary bisphenol A and obesity in U.S. children. Am J Epidemiol. 2013; 177, 12631270.Google Scholar
87. Eng, DS, Lee, JM, Gebremariam, A, et al. and chronic disease risk factors in US children. Pediatrics. 2013; 132, e637e645.Google Scholar
88. Trasande, L, Attina, TM, Blustein, J. Association between urinary bisphenol A concentration and obesity prevalence in children and adolescents. JAMA. 2012; 308, 11131121.Google Scholar
89. Wang, HX, Zhou, Y, Tang, CX, et al. Association between bisphenol A exposure and body mass index in Chinese school children: a cross-sectional study. Environ Health. 2012; 11, 7988.Google Scholar
90. Braun, JM, Lanphear, BP, Calafat, AM, et al. Early-life bisphenol a exposure and child body mass index: a prospective cohort study. Environ Health Perspect. 2014; 122, 12391245.Google Scholar
91. Harley, KG, Aguilar Schall, R, Chevrier, J, et al. Prenatal and postnatal bisphenol A exposure and body mass index in childhood in the CHAMACOS cohort. Environ Health Perspect. 2013; 121, 514520.Google Scholar
92. Vafeiadi, M, Roumeliotaki, T, Myridakis, A, et al. Association of early life exposure to bisphenol A with obesity and cardiometabolic traits in childhood. Environ Res. 2016; 146, 379387.Google Scholar
93. Valvi, D, Casas, M, Mendez, MA, et al. Prenatal bisphenol a urine concentrations and early rapid growth and overweight risk in the offspring. Epidemiology. 2013; 24, 791799.Google Scholar
94. Boberg, J, Taxvig, C, Christiansen, S, Hass, U. Possible endocrine disrupting effects of parabens and their metabolites. Reprod Toxicol. 2010; 30, 301312.Google Scholar
95. Krause, M, Klit, A, Blomberg Jensen, M, et al. Sunscreens: are they beneficial for health? An overview of endocrine disrupting properties of UV-filters. Int J Androl. 2012; 35, 424436.Google Scholar
96. Witorsch, RJ, Thomas, JA. Personal care products and endocrine disruption: a critical review of the literature. Crit Rev Toxicol. 2010; 40(Suppl. 3), 130.Google Scholar
97. Kim, S, Choi, K. Occurrences, toxicities, and ecological risks of benzophenone-3, a common component of organic sunscreen products: a mini-review. Environ Int. 2014; 70, 143157.Google Scholar
98. Sandborgh-Englund, G, Adolfsson-Erici, M, Odham, G, Ekstrand, J. Pharmacokinetics of triclosan following oral ingestion in humans. J Toxicol Environ Health A. 2006; 69, 18611873.Google Scholar
99. Bergman, A, Heindel, JJ, Kasten, T, et al. The impact of endocrine disruption: a consensus statement on the state of the science. Environ Health Perspect. 2013; 121, A1046.Google Scholar
100. Ghazipura, M, McGowan, R, Arslan, A, Hossain, T. Exposure to benzophenone-3 and reproductive toxicity: a systematic review of human and animal studies. Reprod Toxicol. 2017; 73, 175183.Google Scholar
101. Agency for Toxic Substances and Disease Registry. Toxicological Profile for Phenol. 2008. Public Health Service: Atlanta, GA.Google Scholar
102. Agency for Toxic Substances and Disease Registry. Toxicological Profile for Cadmium. 2012. Public Health Service: Atlanta, GA.Google Scholar
103. IARC. IARC Monogrpahs on the Evaluation of Carcinogenic Risks to Humans: Cadmium and Cadmium Compounds. 2012. IARC: Lyon.Google Scholar
104. Agency for Toxic Substances and Disease Registry. Toxicological Profile for Lead. 2007. Public Health Service: Atlanta, GA.Google Scholar
105. Chisolm Jr JJ. Ancient sources of lead and lead poisoning in the United States today. West J Med 1985; 143, 380-381.Google Scholar
106. Agency for Toxic Substances and Disease Registry. Toxicological Profile for Arsenic. 2007. Public Health Service: Atlanta, GA.Google Scholar
107. IARC. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans: Arsenic and Arsenic Compounds. 2012. IARC: Lyon.Google Scholar
108. Carlin, DJ, Naujokas, MF, Bradham, KD, et al. Arsenic and environmental health: state of the science and future research opportunities. Environ Health Perspect. 2016; 124, 890899.Google Scholar
109. Agency for Toxic Substances and Disease Registry. Toxicological Profile for Mercury. 1999. Public Health Services: Atlanta, GA.Google Scholar
110. Clemens, S, Monperrus, M, Donard, OF, Amouroux, D, Guerin, T. Mercury speciation analysis in seafood by species-specific isotope dilution: method validation and occurrence data. Anal Bioanal Chem. 2011; 401, 26992711.Google Scholar
111. Fabelova, L, Vandentorren, S, Vuillermoz, C, et al. Hair concentration of trace elements and growth in homeless children aged <6years: results from the ENFAMS study. Environ Int. 2018; 114, 318325.Google Scholar
112. Marin, S, Ramos, AJ, Cano-Sancho, G, Sanchis, V. Mycotoxins: occurrence, toxicology, and exposure assessment. Food Chem Toxicol. 2013; 60, 218237.Google Scholar
113. IARC. IARC Monogrpahs on the Evaluation of Carcinogenic Risks to Humans: Some Traditional Herbal Medicines, Some Mycotoxins, Naphthalene and Styrene. 2002. IARC: Lyon.Google Scholar
114. Shuaib, FM, Ehiri, J, Abdullahi, A, Williams, JH, Jolly, PE. Reproductive health effects of aflatoxins: a review of the literature. Reprod Toxicol. 2010; 29, 262270.Google Scholar
115. Turner, PC, Collinson, AC, Cheung, YB, et al. Aflatoxin exposure in utero causes growth faltering in Gambian infants. Int J Epidemiol. 2007; 36, 11191125.Google Scholar
116. Gong, Y, Hounsa, A, Egal, S, et al. Postweaning exposure to aflatoxin results in impaired child growth: a longitudinal study in Benin, West Africa. Environ Health Perspect. 2004; 112, 13341338.Google Scholar
117. Asci, A, Durmaz, E, Erkekoglu, P, et al. Urinary zearalenone levels in girls with premature thelarche and idiopathic central precocious puberty. Minerva Pediatr. 2014; 66, 571578.Google Scholar
118. Bandera, EV, Chandran, U, Buckley, B, et al. Urinary mycoestrogens, body size and breast development in New Jersey girls. Sci Total Environ. 2011; 409, 52215227.Google Scholar
119. Pestka, JJ. Deoxynivalenol: mechanisms of action, human exposure, and toxicological relevance. Arch Toxicol. 2010; 84, 663679.Google Scholar
120. Smith, LE, Stoltzfus, RJ, Prendergast, A. Food chain mycotoxin exposure, gut health, and impaired growth: a conceptual framework. Adv Nutr. 2012; 3, 526531.Google Scholar
121. Wu, F, Groopman, JD, Pestka, JJ. Public health impacts of foodborne mycotoxins. Annu Rev Food Sci Technol. 2014; 5, 351372.Google Scholar
122. IARC. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans: Acrylamide. 1994. IARC: Lyon.Google Scholar
123. Duarte-Salles, T, von Stedingk, H, Granum, B, et al. Dietary acrylamide intake during pregnancy and fetal growth - results from the Norwegian mother and child cohort study (MoBa). Environ Health Perspect. 2013; 121, 374379.Google Scholar
124. Pedersen, M, von Stedingk, H, Botsivali, M, et al. Birth weight, head circumference, and prenatal exposure to acrylamide from maternal diet: the European prospective mother–child study (NewGeneris). Environ Health Perspect. 2012; 120, 17391745.Google Scholar
125. Kadawathagedara, M, Botton, J, de Lauzon-Guillain, B, et al. Dietary acrylamide intake during pregnancy and postnatal growth and obesity: results from the Norwegian Mother and Child Cohort Study (MoBa). Environ Int. 2018; 113, 325334.Google Scholar
126. Desai, M, Jellyman, JK, Ross, MG. Epigenomics, gestational programming and risk of metabolic syndrome. Int J Obes. 2015; 39, 633641.Google Scholar
127. Breton, CV, Marsit, CJ, Faustman, E, et al. Small-magnitude effect sizes in epigenetic end points are important in children’s environmental health studies: the Children’s Environmental Health and Disease Prevention Research Center’s Epigenetics Working Group. Environ Health Perspect. 2017; 125, 511526.Google Scholar
128. Bergman, A, Becher, G, Blumberg, B, et al. Manufacturing doubt about endocrine disrupter science – a rebuttal of industry-sponsored critical comments on the UNEP/WHO report “State of the Science of Endocrine Disrupting Chemicals 2012”. Regul Toxicol Pharmacol. 2015; 73, 10071017.Google Scholar
129. Newbold, RR, Padilla-Banks, E, Snyder, RJ, Phillips, TM, Jefferson, WN. Developmental exposure to endocrine disruptors and the obesity epidemic. Reprod Toxicol. 2007; 23, 290296.Google Scholar
130. Kabir, ER, Rahman, MS, Rahman, I. A review on endocrine disruptors and their possible impacts on human health. Environ Toxicol Pharmacol. 2015; 40, 241258.Google Scholar
131. Maqbool, F, Mostafalou, S, Bahadar, H, Abdollahi, M. Review of endocrine disorders associated with environmental toxicants and possible involved mechanisms. Life Sci. 2016; 145, 265273.Google Scholar
132. Heindel, JJ, Newbold, R, Schug, TT. Endocrine disruptors and obesity. Nat Rev Endocrinol. 2015; 11, 653661.Google Scholar
133. Heindel, JJ, Blumberg, B, Cave, M, et al. Metabolism disrupting chemicals and metabolic disorders. Reprod Toxicol. 2017; 68, 333.Google Scholar
134. De Long, NE, Holloway, AC. Early-life chemical exposures and risk of metabolic syndrome. Diabetes Metab Syndr Obes. 2017; 10, 101109.Google Scholar
135. Diamanti-Kandarakis, E, Bourguignon, JP, Giudice, LC, et al. Endocrine-disrupting chemicals: an Endocrine Society scientific statement. Endocr Rev. 2009; 30, 293342.Google Scholar
136. Rodriguez-Rodriguez, P, Ramiro-Cortijo, D, Reyes-Hernandez, CG, et al. Implication of oxidative stress in fetal programming of cardiovascular disease. Front Physiol. 2018; 9, 602615.Google Scholar
137. Carles, S, Charles, MA, Forhan, A, et al. A novel method to describe early offspring body mass index (BMI) trajectories and to study its determinants. PLoS ONE. 2016; 11, e015776616.Google Scholar
138. Robinson, O, Basagana, X, Agier, L, et al. The pregnancy exposome: multiple environmental exposures in the INMA-Sabadell Birth Cohort. Environ Sci Technol. 2015; 49, 1063210641.Google Scholar