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Environmental contaminants and child’s growth

Published online by Cambridge University Press:  05 February 2019

M. Kadawathagedara*
Affiliation:
INSERM, UMR1153 Centre of Research in Epidemiology and Statistics Sorbonne Paris Cité, Team “Early Origin of the Child’s Health and Development” (ORCHAD), Paris Descartes University, Paris, France
B. de Lauzon-Guillain
Affiliation:
INSERM, UMR1153 Centre of Research in Epidemiology and Statistics Sorbonne Paris Cité, Team “Early Origin of the Child’s Health and Development” (ORCHAD), Paris Descartes University, Paris, France
J. Botton
Affiliation:
INSERM, UMR1153 Centre of Research in Epidemiology and Statistics Sorbonne Paris Cité, Team “Early Origin of the Child’s Health and Development” (ORCHAD), Paris Descartes University, Paris, France Faculty of Pharmacy, Université Paris-Sud, Université Paris-Saclay, Châtenay-Malabry, France
*
*Address for correspondence: M. Kadawathagedara, INSERM UMR 1153, Equipe Orchad, 16 Avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France. E-mail: [email protected]

Abstract

Experimental data have suggested that some contaminants in the environment may increase the risk of obesity. Infants can be exposed to chemicals either prenatally, by trans-placental passage of chemicals, or postnatally by their own diet and by other external pathways (air inhalation, dust, hand-to-mouth exposure) after birth. To provide a review of epidemiological evidence on the association between prenatal exposure to chemicals and prenatal and postnatal growth, we present the literature from systematic review articles and international meta-analyses, when available, or recent research articles when summarizing articles were not available. The most studied contaminants in this field were persistent organic pollutants (e.g. organochlorinated pesticides, polychlorinated biphenyls), non-persistent pollutants (e.g. phthalates, bisphenol A), toxic heavy metals (i.e. cadmium, lead and mercury), arsenic, mycotoxins and acrylamide. Mounting evidence suggests that child’s growth may be associated with prenatal or postnatal exposures to environmental contaminants. Improving exposure assessment and studying the contaminants as mixtures should allow to gain knowledge about the environmental determinants of growth and obesity.

Type
Review
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2018 

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