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Effects of sleep restriction during pregnancy on lipids and glucose homeostasis of female offspring submitted to ovariectomy

Published online by Cambridge University Press:  31 October 2018

Rogério Argeri ,
Diego Soares Carvalho ,
Beatriz Duarte Palma ,
Aparecida Emiko Hirata  and
Guiomar Nascimento Gomes Open the ORCID record for Guiomar Nascimento Gomes [Opens in a new window]
Rogério Argeri
Affiliation:
Department of Physiology,University Federal of São Paulo, UNIFESP, São Paulo – S.P., Brazil
Diego Soares Carvalho
Affiliation:
Department of Physiology,University Federal of São Paulo, UNIFESP, São Paulo – S.P., Brazil Federal Institute of Education in Science and Technology, Rondonia, Brazil
Beatriz Duarte Palma
Affiliation:
Centro Universitário São Camilo–São Paulo – S.P., Brazil
Aparecida Emiko Hirata
Affiliation:
Department of Physiology,University Federal of São Paulo, UNIFESP, São Paulo – S.P., Brazil
Guiomar Nascimento Gomes*
Affiliation:
Department of Physiology,University Federal of São Paulo, UNIFESP, São Paulo – S.P., Brazil
*
Address for correspondence: G. N. Gomes, Universidade Federal de Sao Paulo, Physiology, Rua Botucatu no 862, 5õ andar, Sao Paulo 04023-900, Brazil. E-mail: [email protected]
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Abstract

Sleep shortening during pregnancy may alter the mother’s environment, affecting the offspring. Thus, the present study evaluated the metabolic profile of female offspring from sleep-restricted rats during the last week of pregnancy. Pregnant Wistar rats were distributed into two groups: control (C) and sleep restriction (SR). The SR was performed 20 h/day, from 14th to 20th day of pregnancy. At 2 months, half of the offspring were subjected to ovariectomy (OVX); the others, to sham surgery. Studied groups were Csham, Covx, SRsham and SRovx. Cholesterol (HDL, LDL and C-total), triglycerides (TG) and glucose and insulin tolerance tests (GTT–ITT) were evaluated at 8 months. RSsham presented higher values of TG, while SRovx presented higher TG, LDL and C-total. Basal glucose concentration was increased in SRsham and SRovx. These data suggest that SR during pregnancy may be a risk factor for the development of diseases in adult female offspring.

Keywords

glycaemialipids profilematernal sleep restrictionoffspring
Type
Brief Report
Information
Journal of Developmental Origins of Health and Disease , Volume 10 , Issue 3 , June 2019 , pp. 334 - 337
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2018 

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