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The effects of prenatal oxidative stress levels on infant adiposity development during the first year of life

Published online by Cambridge University Press:  10 January 2014

S. L. Loy ,
K. N. S. Sirajudeen  and
J. M. Hamid Jan
S. L. Loy
Affiliation:
Nutrition Programme, School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
K. N. S. Sirajudeen
Affiliation:
Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
J. M. Hamid Jan*
Affiliation:
Nutrition Programme, School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
*
*Address for correspondence: J. M. Hamid Jan, Nutrition Programme, School of Health Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia. (Email: [email protected])
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Abstract

Although numerous studies have been conducted to examine the causal factors of childhood obesity, the implications of intrauterine oxidative stress on early postnatal adiposity development remain to be elucidated. The Universiti Sains Malaysia Birth Cohort Study aimed to investigate the effects of prenatal oxidative stress levels on the development of infant adiposity during the first year of life. This study was conducted on the healthy pregnant women aged 19–40 years, from April 2010 to December 2012 in Kelantan, Malaysia. Maternal blood samples were drawn in the second trimester to analyse for oxidative stress markers. Infant anthropometric measurements were taken at birth, 2, 6 and 12 months of age. A total of 153 pregnant women and full-term infants were included in the analysis. Statistical test was conducted by using multiple linear regression. Through the infant first year of life, as maternal DNA damage level in the second trimester increased, infant weights at birth (β=−0.122, P<0.001), 2 months (β=−0.120, P=0013), 6 months (β=−0.209, P=0.003) and 12 months of age (β=−0.241, P=0.006) decreased after adjusting for confounders. Similar results were noted when infant body mass index-for-age Z-scores and triceps skinfold-for-age Z-scores were used as the adiposity indicators. In conclusion, the present study shows a consistent inverse association between maternal DNA damage and infant adiposity during the first year of life. These infants with reduced growth and adiposity in early postnatal life may have a high tendency to experience catch-up growth during childhood, which could be strongly associated with later obesity.

Keywords

body compositionchild growthnewbornobesitypregnancy
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 5 , Issue 2 , April 2014 , pp. 142 - 151
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2014 

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