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Effects of maternal controlled exercise on offspring adiposity and glucose tolerance

Published online by Cambridge University Press:  10 September 2021

Kristen M. Platt Open the ORCID record for Kristen M. Platt [Opens in a new window] ,
Jenna Przybylowski ,
Richard J. Charnigo ,
Sara Y. Ngo Tenlep ,
Leryn J. Reynolds  and
Kevin J. Pearson
Kristen M. Platt*
Affiliation:
Department of Neuroscience, College of Medicine, University of Kentucky, Lexington, KY, USA
Jenna Przybylowski
Affiliation:
Department of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, KY, USA
Richard J. Charnigo
Affiliation:
Department of Biostatistics, College of Public Health, University of Kentucky, Lexington, KY, USA
Sara Y. Ngo Tenlep
Affiliation:
Department of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, KY, USA
Leryn J. Reynolds
Affiliation:
Department of Human Movement Sciences, Old Dominion University, Norfolk, VA, USA
Kevin J. Pearson
Affiliation:
Department of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, KY, USA
*
Address for correspondence: Kristen M. Platt, Department of Neuroscience, College of Medicine, University of Kentucky, Willard Medical Science Bldg, Rm MS 207, 800 Rose Street, Lexington, KY40536-0200, USA. Email: [email protected]
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Abstract

While metabolic disorders such as obesity and diabetes are costly and deadly to the current population, they are also extremely detrimental to the next generation. Much of the current literature focuses on the negative impact of poor maternal choices on offspring disease, while there is little work examining maternal behaviors that may improve offspring health. Research has shown that voluntary maternal exercise in mouse models improves metabolic function in offspring. In this study, we hypothesized that controlled maternal exercise in a mouse model will effect positive change on offspring obesity and glucose homeostasis. Female mice were separated into three groups: home cage, sedentary, and exercise. The sedentary home cage group was not removed from the home cage, while the sedentary wheel group was removed from the cage and placed in an immobile wheel apparatus. The exercise group was removed from the home cage and run on the same wheel apparatus but with the motor activated at 5–10 m/min for 1 h/d prior to and during pregnancy. Offspring were subjected to oral glucose tolerance testing and body composition analysis. There was no significant difference in offspring glucose tolerance or body composition as a consequence of the maternal exercise intervention compared to the sedentary wheel group. There were no marked negative consequences of the maternal controlled exercise intervention. Further research should clarify the potential advantages of the controlled exercise model and improve experimental techniques to facilitate translation of this research to human applications.

Keywords

Developmental programmingdiabetesgestationmouseobesityrunning
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 13 , Issue 4 , August 2022 , pp. 455 - 462
Copyright
© The Author(s), 2021. Published by Cambridge University Press in association with International Society for Developmental Origins of Health and Disease

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Footnotes

*

These authors contributed equally.

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