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The effect of high maternal linoleic acid on endocannabinoid signalling in rodent hearts

Published online by Cambridge University Press:  09 December 2019

Simone L. Sleep ,
Nirajan Shrestha ,
James S. M. Cuffe Open the ORCID record for James S. M. Cuffe [Opens in a new window] ,
Olivia J. Holland ,
John P. Headrick ,
Andrew J. McAinch  and
Deanne H. Hryciw Open the ORCID record for Deanne H. Hryciw [Opens in a new window]
Simone L. Sleep
Affiliation:
School of Medical Science, Griffith University, Southport, QLD, Australia
Nirajan Shrestha
Affiliation:
School of Medical Science, Griffith University, Southport, QLD, Australia
James S. M. Cuffe
Affiliation:
School of Medical Science, Griffith University, Southport, QLD, Australia School of Biomedical Sciences, The University of Queensland, QLD, St Lucia, Australia
Olivia J. Holland
Affiliation:
School of Medical Science, Griffith University, Southport, QLD, Australia
John P. Headrick
Affiliation:
School of Medical Science, Griffith University, Southport, QLD, Australia
Andrew J. McAinch
Affiliation:
Institute for Health and Sport, Victoria University, Melbourne, Australia Australian Institute for Musculoskeletal Science (AIMSS), Victoria University, St. Albans, VIC, Australia
Deanne H. Hryciw*
Affiliation:
Institute for Health and Sport, Victoria University, Melbourne, Australia School of Environment and Science, Griffith University, Nathan, QLD, Australia
*
Address for correspondence: Dr. Deanne Hryciw, School of Environment and Science, Griffith University, Nathan, QLD, Australia. Email: [email protected]
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Abstract

The endocannabinoid system (ECS), modulated by metabolites of linoleic acid (LA), is important in regulating cardiovascular function. In pregnancy, LA is vital for foetal development. We investigated the effects of elevated LA in H9c2 cardiomyoblasts in vitro and of a high linoleic acid (HLA, 6.21%) or low linoleic acid (LLA, 1.44%) diet during pregnancy in maternal and offspring hearts. H9c2 cell viability was reduced following LA exposure at concentrations between 300 and 1000 µM. HLA diet decreased cannabinoid receptor type 2 (CB2) mRNA expression in foetal hearts from both sexes. However, HLA diet increased CB2 expression in maternal hearts. The mRNA expression of fatty acid amide hydrolase (FAAH) in foetal hearts was higher in females than in males irrespective of diet and N-acyl phosphatidylethanolamine-specific phospholipase D (NAPE-PLD) mRNA expression showed an interaction between diet and sex. Data indicate that a high LA diet alters cell viability and CB2 expression, potentially influencing cardiac function during pregnancy and development of the offspring’s heart.

Keywords

Endocannabinoidsheartlinoleic acid
Type
Brief Report
Information
Journal of Developmental Origins of Health and Disease , Volume 11 , Issue 6 , December 2020 , pp. 617 - 622
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Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2019

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