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Early-life nutritional programming of longevity

Published online by Cambridge University Press:  13 June 2014

A. M. Vaiserman
A. M. Vaiserman*
Affiliation:
D.F. Chebotarev State Institute of Gerontology NAMS of Ukraine, Kiev, Ukraine
*
*Address for correspondence: A. M. Vaiserman, D.F. Chebotarev State Institute of Gerontology, Vyshgorodskaya st. 67, Kiev 04114, Ukraine. (Email [email protected])
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Abstract

Available data from both experimental and epidemiological studies suggest that inadequate diet in early life can permanently change the structure and function of specific organs or homoeostatic pathways, thereby ‘programming’ the individual’s health status and longevity. Sufficient evidence has accumulated showing significant impact of epigenetic regulation mechanisms in nutritional programming phenomenon. The essential role of early-life diet in the development of aging-related chronic diseases is well established and described in many scientific publications. However, the programming effects on lifespan have not been extensively reviewed systematically. The aim of the review is to provide a summary of research findings and theoretical explanations that indicate that longevity can be influenced by early nutrition.

Keywords

aging-associated diseasedevelopmental nutritional programmingepigenetic regulationlongevity
Type
Review
Information
Journal of Developmental Origins of Health and Disease , Volume 5 , Issue 5 , October 2014 , pp. 325 - 338
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2014 

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