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Early postnatal overnutrition impairs VO2max gains with moderate exercise and increase post-exercise muscle damage in adult male rats

Published online by Cambridge University Press:  21 July 2021

Douglas Lopes Almeida Open the ORCID record for Douglas Lopes Almeida [Opens in a new window] ,
Gabriel Sergio Fabricio ,
Laize Peron Tófolo ,
Tatiane Aparecida Ribeiro ,
Camila Cristina Ianoni Matiusso ,
Maiara Vanusa Guedes Ribeiro ,
Anna Rebeka Oliveira Ferreira ,
Audrei Pavanello Open the ORCID record for Audrei Pavanello [Opens in a new window] ,
Ananda Malta  and
Kesia Palma-Rigo
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Douglas Lopes Almeida*
Affiliation:
Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringa, Maringá, Paraná, Brazil Department of Physiology, State University of Londrina, Londrina, Paraná, Brazil
Gabriel Sergio Fabricio
Affiliation:
Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringa, Maringá, Paraná, Brazil
Laize Peron Tófolo
Affiliation:
Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringa, Maringá, Paraná, Brazil
Tatiane Aparecida Ribeiro
Affiliation:
Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringa, Maringá, Paraná, Brazil
Camila Cristina Ianoni Matiusso
Affiliation:
Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringa, Maringá, Paraná, Brazil
Maiara Vanusa Guedes Ribeiro
Affiliation:
Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringa, Maringá, Paraná, Brazil
Anna Rebeka Oliveira Ferreira
Affiliation:
Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringa, Maringá, Paraná, Brazil
Audrei Pavanello
Affiliation:
Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringa, Maringá, Paraná, Brazil
Ananda Malta
Affiliation:
Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringa, Maringá, Paraná, Brazil
Kesia Palma-Rigo
Affiliation:
Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringa, Maringá, Paraná, Brazil Faculdade Adventista Paranaense, Healthy School, Ivatuba, Paraná, Brazil
Paulo Cezar de Freitas Mathias
Affiliation:
Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringa, Maringá, Paraná, Brazil
*
Address for correspondence: Dr. Douglas Lopes Almeida; Department of Physiology, State University of Londrina, UEL – Rodovia Celso Garcia Cid/PR 445 Km 380, Caixa Postal: 10.011 – CEP: 86057-970 – Londrina, PR, Brazil. Email: [email protected]
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Abstract

Exercise counteracts obesity effects, but information on how early-life obesity may affect long-term adaptation to exercise is lacking. This study investigates the impact of early-life postnatal overfeeding (PO) on animals’ adaptation to exercise. Only male Wistar rats were used. On postnatal day (PN) 30, rats from control (NL-9 pups) or PO (SL-3 pups) litters were separated into four groups: NL-sedentary (NL-Se), NL-exercised (NL-Ex), SL-sedentary (SL-Se), and SL-exercised (SL-Ex). Exercised groups performed moderate-intensity exercise, running on a treadmill, from PN30 to PN90. Further experiments were carried out between PN90 and PN92. PO promoted obesity in SL versus NL rats (P < 0.05). Exercise reduced body weight (P < 0.001), body fat (P < 0.01), and improved glucose homeostasis in SL-Ex versus SL-Se. SL-Ex presented lower VO2max (P < 0.01) and higher post-exercise LDH (P < 0.05) compared to NL-Ex rats. Although moderate exercise counteracted obesity in SL rats, early-life overnutrition restricts fitness gains in adulthood, indicating that early obesity may impair animals’ adaptation to exercise.

Keywords

Early postnatal overfeedingdevelopmental obesitymoderate exercisephysical fitness
Type
Brief Reports
Information
Journal of Developmental Origins of Health and Disease , Volume 13 , Issue 3 , June 2022 , pp. 406 - 410
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Copyright
© The Author(s), 2021. Published by Cambridge University Press in association with International Society for Developmental Origins of Health and Disease

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Footnotes

*

Co-first authors.

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