Hostname: page-component-586b7cd67f-dsjbd Total loading time: 0 Render date: 2024-11-22T14:03:37.371Z Has data issue: false hasContentIssue false
  • English
  • Français

Circulating maternal and umbilical cord steroid hormone and insulin-like growth factor concentrations in twin and singleton pregnancies

Published online by Cambridge University Press:  08 October 2018

L. C. Houghton Open the ORCID record for L. C. Houghton [Opens in a new window] ,
M. Lauria ,
P. Maas ,
F. Z. Stanczyk ,
R. N. Hoover  and
R. Troisi
L. C. Houghton
Affiliation:
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
M. Lauria
Affiliation:
Dartmouth Hitchcock Medical Center, Geisel School of Medicine, Lebanon, NH, USA
P. Maas
Affiliation:
Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
F. Z. Stanczyk
Affiliation:
Division of Reproductive Endocrinology and Infertility, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA
R. N. Hoover
Affiliation:
Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
R. Troisi*
Affiliation:
Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
*
Address for correspondence: Dr R. Troisi, Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Drive, MSC, 9780, Building/Room 9609/7E128, Rockville, MD 20850-9780, USA. E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

In addition to being associated with a higher risk of complications during pregnancy, twinning may also be a proxy for altered hormonal exposure for mothers and twin offspring, with implications for their health later in life. We compared maternal and fetal steroid hormone and insulin-like growth factor concentrations between singleton (n=62) and twin (n=41) pregnancies. Maternal concentrations of androgens, estrogens, insulin-like growth factor (IGF)-1, IGF-binding protein (BP)-3 and prolactin were quantified during the third trimester and at delivery, as well as in the fetal circulation at birth. Geometric means accounting for gestational age were calculated for hormone concentrations and compared between matched twin and singleton pregnancies. Most maternal hormone concentrations were modestly higher in twin than in singleton pregnancies in the third trimester (ranging from 8.3% for IGF-1 to 17.1% for estradiol) and at delivery (ranging from 11.1% for IGFBP-3 to 15.2% for estriol). Cord serum hormones were generally similar in twin and singleton pregnancies, except for IGFBP-3, which was 200% lower in twins. The modest differences in maternal hormones in late gestation seem unlikely to explain alterations in hormonally related disease risk in mothers of twins compared with singletons. The large deficit of IGFBP-3 in the fetal circulation of twins at birth may allow for sufficient concentrations of IGF-2 for growth and development in an environment of shared nutritional resources.

Keywords

androgenestrogenIGF-1pregnancytwins
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 10 , Issue 2 , April 2019 , pp. 232 - 236
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2018. 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Hoekstra, C, Zhao, ZZ, Lambalk, CB, et al. Dizygotic twinning. Hum Reprod Update. 2008; 14, 37–47.Google Scholar
2. Ros, HS, Cnattingius, S, Lipworth, L. Comparison of risk factors for preeclampsia and gestational hypertension in a population-based cohort study. Am J Epidemiol. 1998; 147, 1062–1070.Google Scholar
3. Kim, JD, Leyva, S, Diano, S. Hormonal regulation of the hypothalamic melanocortin system. Front Physiol. 2014; 5, 480.Google Scholar
4. Xue, F, Michels, KB. Intrauterine factors and risk of breast cancer: a systematic review and meta-analysis of current evidence. Lancet Oncol. 2007; 8, 1088–1100.Google Scholar
5. Nechuta, S, Paneth, N, Velie, EM. Pregnancy characteristics and maternal breast cancer risk: a review of the epidemiologic literature. Cancer Causes Control. 2010; 21, 967–989.Google Scholar
6. Albrektsen, G, Heuch, I, Kvale, G. Multiple births, sex of children and subsequent breast-cancer risk for the mothers: a prospective study in Norway. Int J cancer. 1995; 60, 341–344.Google Scholar
7. Neale, RE, Darlington, S, Murphy, MFG, et al. The effects of twins, parity and age at first birth on cancer risk in Swedish women. Twin Res Hum Genet. 2005; 8, 156–162.Google Scholar
8. Murphy, MF, Broeders, MJ, Carpenter, LM, Gunnarskog, J, Leon, DA. Breast cancer risk in mothers of twins. Br J Cancer. 1997; 75, 1066–1068.Google Scholar
9. Lambe, M, Hsieh, C, Tsaih, S, et al. Maternal risk of breast cancer following multiple births: a nationwide study in Sweden. Cancer Causes Control. 1996; 7, 533–538.Google Scholar
10. Ji, J, Forsti, A, Sundquist, J, Hemminki, K. Risks of breast, endometrial, and ovarian cancers after twin births. Endocr Relat Cancer. 2007; 14, 703–711.Google Scholar
11. Ekbom, A, Hsieh, CC, Lipworth, L, Adami, HQ, Trichopoulos, D. Intrauterine environment and breast cancer risk in women: a population-based study. J Natl Cancer Inst. 1997; 89, 71–76.Google Scholar
12. Potischman, N, Troisi, R. In-utero and early life exposures in relation to risk of breast cancer. Cancer Causes Control. 1999; 10, 561–573.Google Scholar
13. Hsieh, CC, Lan, SJ, Ekbom, A, et al. Twin membership and breast cancer risk. Am J Epidemiol. 1992; 136, 1321–1326.Google Scholar
14. Weiss, HA, Potischman, NA, Brinton, LA, et al. Prenatal and perinatal risk factors for breast cancer in young women. Epidemiology. 1997; 8, 181–187.Google Scholar
15. Holm, NV. Studies of cancer etiology in the Danish twin population. I. Breast cancer. Prog Clin Biol Res. 1981; 69(Pt C), 211–216.Google Scholar
16. Braun, MM, Ahlbom, A, Floderus, B, Brinton, LA, Hoover, RN. Effect of twinship on incidence of cancer of the testis, breast, and other sites (Sweden). Cancer Causes Control. 1995; 6, 519–524.Google Scholar
17. Sanderson, M, Daling, JR, Doody, DR, Malone, KE.. Perinatal factors and mortality from breast cancer. Cancer Epidemiol Biomarkers Prev. 2006; 15, 1984–1987.Google Scholar
18. Kaprio, J, Teppo, L, Koskenvuo, M, Pukkala, E. Cancer in adult same-sexed twins: a historical cohort study. Prog Clin Biol Res. 1981; 69 PtC, 217–223.Google Scholar
19. Verkasalo, PK, Kaprio, J, Pukkala, E, Koskenvuo, M.. Breast cancer risk in monozygotic and dizygotic female twins: a 20-year population-based cohort study in Finland from 1976 to 1995. Cancer Epidemiol Biomarkers Prev. 1999; 8, 271–274.Google Scholar
20. Goebelsmann, U, Horton, R, Mestman, JH, et al. Male pseudohermaphroditism due to testicular 17-hydroxysteroid dehydrogenase deficiency. J Clin Endocrinol Metab. 1973; 36, 867–879.Google Scholar
21. Probst-Hensch, NM, Ingles, SA, Diep, AT, et al. Aromatase and breast cancer susceptibility. Endocr Relat Cancer. 1999; 6, 165–173.Google Scholar
22. Scott, JZ, Stanczyk, FZ, Goebelsmann, U, Mishell, DR.. A double-antibody radioimmunoassay for serum progesterone using progesterone-3-(o-carboxymethyl)oximino-[125l]-iodo-histamine as radioligand. Steroids. 1978; 31, 393–405.Google Scholar
23. Goebelsmann, U, Arce, JJ, Thorneycroft, IH, Mishell, DR. Serum testosterone concentrations in women throughout the menstrual cycle and following HCG administration. Am J Obstet Gynecol. 1974; 119, 445–452.Google Scholar
24. Yudkin, PL, Aboualfa, M, Eyre, JA, Redman, CW, Wilkinson, AR. New birthweight and head circumference centiles for gestational ages 24 to 42 weeks. Early Hum Dev. 1987; 15, 45–52.Google Scholar
25. American College of Obstetricians and Gynecologists. Methods for estimating the due date. Committee Opinion No. 700. Obs Gynecol 2017. 2017; 129, e150–e154.Google Scholar
26. StataCorp. Stata Statistical Software: Release 13. 2013.Google Scholar
27. Duff, DB, Brown, JB. Urinary oestriol excretion in twin pregnancies. J Obstet Gynaecol Br Commonw. 1974; 81, 695–700.Google Scholar
28. TambyRaja, RL, Ratnam, SS. Plasma steroid changes in twin pregnancies. Prog Clin Biol Res. 1981; 69A, 189–195.Google Scholar
29. Thomas, HV, Murphy, MF, Key, TJ, et al. Pregnancy and menstrual hormone levels in mothers of twins compared to mothers of singletons. Ann Hum Biol. 1998; 25, 69–75.Google Scholar
30. Kazer, RR, Cheng, ER, Unterman, TG, Glick, RP. Maternal plasma concentrations of insulin-like growth factor-I (IGF-I) and human placental lactogen (hPL) in twin pregnancies. Acta Genet Med Gemellol (Roma). 1991; 40, 383–387.Google Scholar
31. Langford, KS, Nicolaides, KH, Jones, J, et al. Serum insulin-like growth factor-binding protein-3 (IGFBP-3) levels and IGFBP-3 protease activity in normal, abnormal, and multiple human pregnancy. J Clin Endocrinol Metab. 1995; 80, 21–27.Google Scholar
32. Lof, M, Hilakivi-Clarke, L, Sandin, SS, et al. Dietary fat intake and gestational weight gain in relation to estradiol and progesterone plasma levels during pregnancy: a longitudinal study in Swedish women. BMC Womens Health. 2009; 9, 10.Google Scholar
33. Lagiou, P, Lagiou, A, Samoli, E, et al. Diet during pregnancy and levels of maternal pregnancy hormones in relation to the risk of breast cancer in the offspring. Eur J Cancer Prev. 2006; 15, 20–26.Google Scholar
34. Wuu, J, Hellerstein, S, Lipworth, L, et al. Correlates of pregnancy oestrogen, progesterone and sex hormone-binding globulin in the USA and China. Retrieved 15 June 2017 from https://insights.ovid.com/pubmed?pmid=12131662.Google Scholar
35. Rifas-Shiman, SL, Fleisch, A, et al. First and second trimester gestational weight gains are most strongly associated with cord blood levels of hormones at delivery important for glycemic control and somatic growth. Metabolism. 2017; 69, 112–119.Google Scholar
36. Kappel, B, Hansen, K, Moller, J, Faaborg-Andersen, J. Human placental lactogen and dU-estrogen levels in normal twin pregnancies. Acta Genet Med Gemellol (Roma). 1985; 34, 59–65.Google Scholar
Supplementary material: File

Houghton et al. supplementary material

Table S1

Download Houghton et al. supplementary material(File)
File 17.3 KB
Supplementary material: File

Houghton et al. supplementary material

Table S2

Download Houghton et al. supplementary material(File)
File 15.5 KB
Supplementary material: File

Houghton et al. supplementary material

Table S3

Download Houghton et al. supplementary material(File)
File 16.5 KB
Supplementary material: File

Houghton et al. supplementary material

Table S4

Download Houghton et al. supplementary material(File)
File 15.9 KB
Supplementary material: File

Houghton et al. supplementary material

Table S5

Download Houghton et al. supplementary material(File)
File 16.9 KB
Supplementary material: File

Houghton et al. supplementary material

Table S6

Download Houghton et al. supplementary material(File)
File 14.7 KB
Supplementary material: File

Houghton et al. supplementary material

Table S7

Download Houghton et al. supplementary material(File)
File 15 KB
Supplementary material: File

Houghton et al. supplementary material

Table S8

Download Houghton et al. supplementary material(File)
File 15.2 KB