Hostname: page-component-cd9895bd7-gbm5v Total loading time: 0 Render date: 2024-12-23T10:24:51.108Z Has data issue: false hasContentIssue false
  • English
  • Français

Caregiver-reported physical health status of children and young people with fetal alcohol spectrum disorder

Published online by Cambridge University Press:  09 June 2020

N. Reid Open the ORCID record for N. Reid [Opens in a new window] ,
N. Hayes ,
S. B. Young ,
L. K. Akison  and
K. M. Moritz Open the ORCID record for K. M. Moritz [Opens in a new window]
N. Reid*
Affiliation:
Child Health Research Centre, The University of Queensland, South Brisbane, QLD, Australia
N. Hayes
Affiliation:
Child Health Research Centre, The University of Queensland, South Brisbane, QLD, Australia
S. B. Young
Affiliation:
Child Health Research Centre, The University of Queensland, South Brisbane, QLD, Australia
L. K. Akison
Affiliation:
Child Health Research Centre, The University of Queensland, South Brisbane, QLD, Australia School of Biomedical Sciences, The University of Queensland, St Lucia, QLD, Australia
K. M. Moritz
Affiliation:
Child Health Research Centre, The University of Queensland, South Brisbane, QLD, Australia School of Biomedical Sciences, The University of Queensland, St Lucia, QLD, Australia
*
Address for correspondence: Natasha Reid, Child Health Research Centre, The University of Queensland, Room 408, Centre for Children’s Health Research (CCHR), 62 Graham St, South Brisbane, QLD4101, Australia. E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

While fetal alcohol spectrum disorder (FASD) has primarily been thought of as a neurodevelopmental condition, research is beginning to highlight its ‘whole-body’ implications. Accordingly, the current study sought to provide a snapshot of potential health issues. Caregivers of children (median age of 12 years) with an FASD diagnosis were invited to participate in an online survey. Information relating to sample demographics, FASD status of the child and health outcomes were collected. The prevalence of health conditions reported in the FASD sample was compared against national prevalence data. Multiple linear regression utilising a stepwise approach was used to investigate potential predictors of the number of diagnosed health conditions. Survey data were from an international cohort (n = 197), with the majority of respondents based in Australia (40.2%) or the United States (27.7%). The most commonly reported diagnosed health conditions were eye conditions (44.7%), asthma (34.5%), heart conditions (34.0%) and skin conditions (27.4%). Binomial testing indicated the proportion of children diagnosed with these disorders was generally higher in the current FASD population, compared to national prevalence data. Indicators of metabolic dysfunction including diabetes and obesity were not significantly different compared to national prevalence data. Age of FASD diagnosis, existence of comorbid mental health conditions and the primary caregiver being in paid work were identified as being associated with the prevalence of diagnosed health conditions. Overall, the study has provided an up-to-date snapshot of health problems reported in a sample of children with FASD, confirming their increased risk of adverse health outcomes.

Keywords

Fetal alcohol spectrum disorderprenatal alcohol exposurephysical health outcomes
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 12 , Issue 3 , June 2021 , pp. 420 - 427
Check for updates
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2020

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Harding, K, Flannigan, K, McFarlane, A. Policy Action Paper: Toward a Standard Definition of Fetal Alcohol Spectrum Disorder in Canada, 2019. CanFASD, Vancouver, BC.Google Scholar
Mattson, SN, Bernes, GA, Doyle, LR. Fetal alcohol spectrum disorders: a review of the neurobehavioral deficits associated with prenatal alcohol exposure. Alcohol Clin Exp Res. 2019; 43 (6), 1046–1062.Google ScholarPubMed
Barker, DJ. The origins of the developmental origins theory. J Intern Med. 2007; 261 (5), 412–417.CrossRefGoogle ScholarPubMed
Hales, CN, Barker, DJ, Clark, PM, et al. Fetal and infant growth and impaired glucose tolerance at age 64. BMJ. 1991; 303 (6809), 1019–1022.CrossRefGoogle ScholarPubMed
Mandy, M, Nyirenda, M. Developmental origins of health and disease: the relevance to developing nations. Int Health. 2018; 10 (2), 66–70.CrossRefGoogle ScholarPubMed
Himmelreich, M, Lutke, CJ, Travis, E. The lay of the land: final results of a health survey of 500 + adults with diagnosed FASD. In 7th International Fetal Alcohol Spectrum Disorder Conference, 2017, Vancouver, Canada.Google Scholar
Sarman, I. Review shows that early foetal alcohol exposure may cause adverse effects even when the mother consumes low levels. Acta Paediatr. 2018; 107 (6), 938–941.CrossRefGoogle ScholarPubMed
Popova, S, Lange, S, Shield, K, et al. Comorbidity of fetal alcohol spectrum disorder: a systematic review and meta-analysis. Lancet. 2016; 387 (10022), 978–987.CrossRefGoogle ScholarPubMed
Reid, N, Moritz, KM, Akison, LK. Adverse health outcomes associated with fetal alcohol exposure: a systematic review focused on immune-related outcomes. Pediatr Allergy Immunol. 2019; doi: 10.1111/pai.13099, Epub ahead of print.CrossRefGoogle ScholarPubMed
Reid, N, Akison, LK, Hoy, W, Moritz, KM. Adverse health outcomes associated with fetal alcohol exposure: a systematic review focused on cardio-renal outcomes. J Stud Alcohol Drugs. 2019, 515–523.CrossRefGoogle ScholarPubMed
Akison, LK, Reid, N, Wyllie, M, Moritz, KM. Adverse health outcomes in offspring associated with fetal alcohol exposure: a systematic review of clinical and preclinical studies with a focus on metabolic and body composition outcomes. Alcohol Clin Exp Res. 2019; 43, 1324–1343.CrossRefGoogle ScholarPubMed
Akison, LK, Moritz, KM, Reid, N. Adverse reproductive outcomes associated with fetal alcohol exposure: a systematic review. Reproduction. 2019; 157 (4), 329–343.CrossRefGoogle ScholarPubMed
Cook, JC, Lynch, ME, Coles, CD. Association analysis: fetal alcohol spectrum disorders and hypertension status in children and adolescents. Alcohol Clin Exp Res. 2019; 43 (8), 1727–1733.CrossRefGoogle ScholarPubMed
Price, A, Cook, PA, Norgate, S, Mukherjee, R. Prenatal alcohol exposure and traumatic childhood experiences: a systematic review. Neurosci Biobehav Rev. 2017; 80, 89–98.CrossRefGoogle ScholarPubMed
Harris, PA, Taylor, R, Thielke, R, Payne, J, Gonzalez, N, Conde, JG. Research electronic data capture (REDCap) – a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009; 42 (2), 377–381.CrossRefGoogle ScholarPubMed
Australian Bureau of Statistics. National Health Survey: First Results, 2017–2018 – Australia. Canberra (ACT): Commonwealth of Australia, 2018 ABS cat. no. 4364.0.55.001.Google Scholar
Kuczmarski, RJ, Ogden, CL, Grummer-Strawn, LM, et al. CDC growth charts: United States. Adv Data. 2000 (314), 1–27.Google ScholarPubMed
Barlow, SE. Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. Pediatrics. 2007; 120 (Supplement 4), S164–S192.CrossRefGoogle ScholarPubMed
Gummel, K, Ygge, J. Ophthalmologic findings in Russian children with fetal alcohol syndrome. Eur J Ophthalmol. 2013; 23 (6), 823–830.CrossRefGoogle ScholarPubMed
Petrelli, B, Bendelac, L, Hicks, GG, Fainsod, A. Insights into retinoic acid deficiency and the induction of craniofacial malformations and microcephaly in fetal alcohol spectrum disorder. Genesis. 2019; 57 (1), e23278.CrossRefGoogle ScholarPubMed
Cvekl, A, Wang, WL. Retinoic acid signaling in mammalian eye development. Exp Eye Res. 2009; 89 (3), 280–291.CrossRefGoogle ScholarPubMed
Rubinow, KB, Rubinow, DR. In immune defense: redefining the role of the immune system in chronic disease. Dialogues Clin Neurosci. 2017; 19 (1), 19–26.Google ScholarPubMed
Perl, E, Waxman, JS. Reiterative mechanisms of retinoic acid signaling during vertebrate heart development. J Dev Biol. 2019; 7 (2), 11.CrossRefGoogle ScholarPubMed
Gray, SP, Cullen‐McEwen, LA, Bertram, JF, Moritz, KM. Mechanism of alcohol‐induced impairment in renal development: could it be reduced by retinoic acid? Clin Exp Pharmacol Physiol. 2012; 39 (9), 807–813.CrossRefGoogle ScholarPubMed
Hannigan, JH, Martier, SS, Naber, JM. Independent associations among maternal alcohol consumption and infant thyroxine levels and pregnancy outcome. Alcohol Clin Exp Res. 1995; 19 (1), 135–141.CrossRefGoogle ScholarPubMed
Ceccanti, M, De Nicolo, S, Mancinelli, R, et al. NGF and BDNF long-term variations in the thyroid, testis and adrenal glands of a mouse model of fetal alcohol spectrum disorders. Ann Ist Super Sanita. 2013; 49 (4), 383–390.Google ScholarPubMed
Roozen, S, Olivier, L, Niemczyk, J, et al. Nocturnal incontinence in children with fetal alcohol spectrum disorders (FASD) in a South African cohort. J Pediatr Urol. 2017; 13 (5), 496.e491–496.e497.CrossRefGoogle Scholar
Cupelli, ET, Escallier, L, Galambos, N, Xiang, S, Franco, I. Sensory processing differences and urinary incontinence in school-aged children. J Pediatr Urol. 2014; 10 (5), 880–885.CrossRefGoogle ScholarPubMed
Collis, D, Kennedy‐Behr, A, Kearney, L. The impact of bowel and bladder problems on children’s quality of life and their parents: a scoping review. Child Care Health Dev. 2019; 45 (1), 1–14.CrossRefGoogle ScholarPubMed
Ohrnberger, J, Fichera, E, Sutton, M. The relationship between physical and mental health: a mediation analysis. Social Sci Med. 2017; 195, 42–49.CrossRefGoogle ScholarPubMed
Valderas, JM, Starfield, B, Sibbald, B, Salisbury, C, Roland, M. Defining comorbidity: implications for understanding health and health services. Ann Fam Med. 2009; 7 (4), 357–363.CrossRefGoogle ScholarPubMed
Cobben, JM, Krzyzewska, IM, Venema, A, et al. DNA methylation abundantly associates with fetal alcohol spectrum disorder and its subphenotypes. Epigenomics. 2018; 11 (7), 767–785.CrossRefGoogle Scholar
Seyhan, AA, Carini, C. Are innovation and new technologies in precision medicine paving a new era in patients centric care? J Transl Med. 2019; 17 (1), 114.CrossRefGoogle ScholarPubMed
Reid, N, Moritz, KM. Caregiver and family quality of life for children with fetal alcohol spectrum disorder. Res Dev Disabil. 2019; 94, 103478.CrossRefGoogle ScholarPubMed
Schaink, AK, Kuluski, K, Lyons, RF, et al. A scoping review and thematic classification of patient complexity: offering a unifying framework. J Comorb. 2012; 2 (1), 1–9.CrossRefGoogle ScholarPubMed
De, S, Small, J, Baur, LA. Overweight and obesity among children with developmental disabilities. J Intellect Dev Disabil. 2008; 33 (1), 43–47.CrossRefGoogle ScholarPubMed
Gurney, JG, McPeeters, ML, Davis, MM. Parental report of health conditions and health care use among children with and without autism: National Survey of Children’s Health. Arch Pediatr Adolesc Med. 2006; 160 (8), 825–830.CrossRefGoogle ScholarPubMed
Brown, JM, Bland, R, Jonsson, E, Greenshaw, AJ. The standardization of diagnostic criteria for fetal alcohol spectrum disorder (FASD): implications for research, clinical practice and population health. Can J Psychiatry. 2019; 64 (3), 169–176.CrossRefGoogle ScholarPubMed
Supplementary material: File

Reid et al. supplementary material

Table S1

Download Reid et al. supplementary material(File)
File 16.2 KB