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Association of selenium and copper with lipids in umbilical cord blood

Published online by Cambridge University Press:  22 April 2014

E. M. Wells ,
A. Navas-Acien ,
B. J. Apelberg ,
J. B. Herbstman ,
J. M. Jarrett ,
Y. H. Lin ,
C. P. Verdon Open the ORCID record for C. P. Verdon [Opens in a new window] ,
C. Ward ,
K. L. Caldwell  and
J. R. Hibbeln
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E. M. Wells*
Affiliation:
School of Health Sciences, Purdue University, West Lafayette, IN, USA
A. Navas-Acien
Affiliation:
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
B. J. Apelberg
Affiliation:
Office of Policy, Center for Tobacco Products, Food and Drug Administration, Rockville, MD, USA
J. B. Herbstman
Affiliation:
Columbia Center for Children's Environmental Health, Columbia University Mailman School of Public Health, New York, NY, USA
J. M. Jarrett
Affiliation:
National Center for Environmental Health, Centers for Disease Control and Prevention, Division of Laboratory Sciences, Atlanta, GA, USA
Y. H. Lin
Affiliation:
National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA
C. P. Verdon
Affiliation:
National Center for Environmental Health, Centers for Disease Control and Prevention, Division of Laboratory Sciences, Atlanta, GA, USA
C. Ward
Affiliation:
National Center for Environmental Health, Centers for Disease Control and Prevention, Division of Laboratory Sciences, Atlanta, GA, USA
K. L. Caldwell
Affiliation:
National Center for Environmental Health, Centers for Disease Control and Prevention, Division of Laboratory Sciences, Atlanta, GA, USA
J. R. Hibbeln
Affiliation:
National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA
R. U. Halden
Affiliation:
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA Center for Environmental Security, Biodesign Institute, Arizona State University, Tempe, AZ, USA
F. R. Witter
Affiliation:
Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA
L. R. Goldman
Affiliation:
George Washington University School of Public Health and Health Services, Washington, DC, USA
*
*Address for correspondence: E. M. Wells, School of Health Sciences, Purdue University, 550 Stadium Mall Drive, HAMP 1269, West Lafayette, IN 47907, USA. (Email: [email protected])
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Abstract

Altered levels of selenium and copper have been linked with altered cardiovascular disease risk factors including changes in blood triglyceride and cholesterol levels. However, it is unclear whether this can be observed prenatally. This cross-sectional study includes 274 singleton births from 2004 to 2005 in Baltimore, Maryland. We measured umbilical cord serum selenium and copper using inductively coupled plasma mass spectrometry. We evaluated exposure levels vis-à-vis umbilical cord serum triglyceride and total cholesterol concentrations in multivariable regression models adjusted for gestational age, birth weight, maternal age, race, parity, smoking, prepregnancy body mass index, n-3 fatty acids and methyl mercury. The percent difference in triglycerides comparing those in the highest v. lowest quartile of selenium was 22.3% (95% confidence interval (CI): 7.1, 39.7). For copper this was 43.8% (95% CI: 25.9, 64.3). In multivariable models including both copper and selenium as covariates, copper, but not selenium, maintained a statistically significant association with increased triglycerides (percent difference: 40.7%, 95% CI: 22.1, 62.1). There was limited evidence of a relationship of increasing selenium with increasing total cholesterol. Our findings provide evidence that higher serum copper levels are associated with higher serum triglycerides in newborns, but should be confirmed in larger studies.

Keywords

copperinfantnewbornseleniumtotal cholesteroltriglyceride
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 5 , Issue 4 , August 2014 , pp. 281 - 287
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2014 

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