Hostname: page-component-586b7cd67f-rcrh6 Total loading time: 0 Render date: 2024-11-29T15:18:13.808Z Has data issue: false hasContentIssue false
  • English
  • Français

Supplemental folic acid and/or multivitamins in pregnancy is associated with a decreased risk of childhood and adolescent nasopharyngeal carcinoma

Published online by Cambridge University Press:  15 November 2021

Yue Yan ,
Chuanbo Xie ,
Shi Di ,
Zhonghao Wang ,
Minqing Wu ,
Yanhong Li ,
Yuying Liu  and
Rou Jiang Open the ORCID record for Rou Jiang [Opens in a new window]
Yue Yan
Affiliation:
Cancer Prevention Center, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Collaborative Innovation Center for Cancer Medicine, Guangzhou, P. R. China
Chuanbo Xie
Affiliation:
Cancer Prevention Center, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Collaborative Innovation Center for Cancer Medicine, Guangzhou, P. R. China
Shi Di
Affiliation:
Cancer Prevention Center, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Collaborative Innovation Center for Cancer Medicine, Guangzhou, P. R. China
Zhonghao Wang
Affiliation:
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China
Minqing Wu
Affiliation:
Cancer Prevention Center, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Collaborative Innovation Center for Cancer Medicine, Guangzhou, P. R. China
Yanhong Li
Affiliation:
Cancer Prevention Center, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Collaborative Innovation Center for Cancer Medicine, Guangzhou, P. R. China
Yuying Liu*
Affiliation:
Cancer Prevention Center, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Collaborative Innovation Center for Cancer Medicine, Guangzhou, P. R. China
Rou Jiang*
Affiliation:
Cancer Prevention Center, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Collaborative Innovation Center for Cancer Medicine, Guangzhou, P. R. China
*
Address for correspondence: Rou Jiang, Cancer Prevention Center, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, P. R. China. Email: [email protected]; Yuying Liu, Cancer Prevention Center, Sun Yat-sen University Cancer Center, 651Dongfeng Road East, Guangzhou 510060, P. R. China. Email: [email protected]
Address for correspondence: Rou Jiang, Cancer Prevention Center, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, P. R. China. Email: [email protected]; Yuying Liu, Cancer Prevention Center, Sun Yat-sen University Cancer Center, 651Dongfeng Road East, Guangzhou 510060, P. R. China. Email: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

The aim of this study was to evaluate the association between prenatal and neonatal period exposures and the risk of childhood and adolescent nasopharyngeal carcinoma (NPC). From January 2009 to January 2016, a total of 46 patients with childhood and adolescent NPC (i.e., less than 18 years of age) who were treated at Sun Yat-sen University Cancer Center were screened as cases, and a total of 45 cancer-free patients who were treated at Sun Yat-sen University Zhongshan Ophthalmic Center were selected as controls. The association between maternal exposures during pregnancy and obstetric variables and the risk of childhood and adolescent NPC was evaluated using logistic regression analysis. Univariate analysis revealed that compared to children and adolescents without a family history of cancer, those with a family history of cancer had a significantly higher risk of childhood and adolescent NPC [odds ratios (OR) = 3.15, 95% confidence interval (CI) = 1.02–9.75, P = 0.046], and the maternal use of folic acid and/or multivitamins during pregnancy was associated with a reduced risk of childhood and adolescent NPC in the offspring (OR = 0.07, 95% CI = 0.02–0.25, P < 0.001). After multivariate analysis, only the maternal use of folic acid and/or multivitamins during pregnancy remained statistically significant. These findings suggest that maternal consumption of folic acid and/or multivitamins during pregnancy is associated with a decreased risk of childhood and adolescent NPC in the offspring.

Keywords

Folic acidmultivitaminspregnancychildhood and adolescent NPC risk
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 13 , Issue 5 , October 2022 , pp. 550 - 555
Check for updates
Copyright
© The Author(s), 2021. Published by Cambridge University Press in association with International Society for Developmental Origins of Health and Disease

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

Yue Yan and Chuanbo Xie are contributed equally to this paper.

References

Wigle, DT, Arbuckle, TE, Turner, MC, et al. Epidemiologic evidence of relationships between reproductive and child health outcomes and environmental chemical contaminants. J Toxicol Environ Health B Crit Rev. 2008; 11(5-6), 373–517.CrossRefGoogle ScholarPubMed
IPCS (International Programme on Chemical Safety). Principles for evaluating health risks in children associated with exposure to chemicals. Environ Health Criter. 2006; 237, 115–126.Google Scholar
Linet, MS, Wacholder, S, Zahm, SH. Interpreting epidemiologic research: lessons from studies of childhood cancer. Pediatrics. 2003; 112(1 Pt 2), 218–232.CrossRefGoogle ScholarPubMed
Website of Hong Kong Cancer Registry, Hospital Authority: www3.ha.org.hk/cancereg, 1975–1983. Google Scholar
Wei, WI, Sham, JS. Nasopharyngeal carcinoma. Lancet. 2005; 365(9476), 2041–2054.CrossRefGoogle ScholarPubMed
Ayan, I, Kaytan, E, Ayan, N. Childhood nasopharyngeal carcinoma: from biology to treatment. Lancet Oncol. 2003; 4(1), 13–21.CrossRefGoogle ScholarPubMed
Ozyar, E, Selek, U, Laskar, S, et al. Treatment results of 165 pediatric patients with non-metastatic nasopharyngeal carcinoma: a Rare Cancer Network study. Radiother Oncol. 2006; 81(1), 39–46.CrossRefGoogle ScholarPubMed
Lu, S, Chang, H, Sun, X, et al. Long-term outcomes of nasopharyngeal carcinoma in 148 children and adolescents. Medicine (Baltimore). 2016; 95(17), e3445.Google ScholarPubMed
Gaziano, JM, Sesso, HD, Christen, WG, et al. Multivitamins in the prevention of cancer in men: the Physiciansʼ Health Study II randomized controlled trial. JAMA. 2012; 308(18), 1871–1880.CrossRefGoogle ScholarPubMed
Metayer, C, Milne, E, Dockerty, JD, et al. Maternal supplementation with folic acid and other vitamins and risk of leukemia in offspring: a Childhood Leukemia International Consortium study. Epidemiology. 2014; 25(6), 811–822.CrossRefGoogle ScholarPubMed
Milne, E, Greenop, KR, Bower, C, et al. Maternal use of folic acid and other supplements and risk of childhood brain tumors. Cancer Epidemiol Biomarkers Prev. 2012; 21(11), 1933–1941.CrossRefGoogle ScholarPubMed
Goh, YI, Bollano, E, Einarson, TR, Koren, G. Prenatal multivitamin supplementation and rates of pediatric cancers: a meta-analysis. Clin Pharmacol Ther. 2007; 81(5), 685–691.CrossRefGoogle ScholarPubMed
Zeng, FF, Liu, YT, Lin, XL, et al. Folate, vitamin B6, vitamin B12 and methionine intakes and risk for nasopharyngeal carcinoma in Chinese adults: a matched case-control study. Br J Nutr. 2016; 115(1), 121–128.CrossRefGoogle ScholarPubMed
Christman, JK, Sheikhnejad, G, Dizik, M, Abileah, S, Wainfan, E. Reversibility of changes in nucleic acid methylation and gene expression induced in rat liver by severe dietary methyl deficiency. Carcinogenesis. 1993; 14(4), 551–557.CrossRefGoogle ScholarPubMed
Choi, SW, Mason, JB. Folate and carcinogenesis: an integrated scheme. J Nutr. 2000; 130(2), 129–132.CrossRefGoogle Scholar
Fenech, M. The role of folic acid and Vitamin B12 in genomic stability of human cells. Mutat Res. 2001; 475(1-2), 57–67.CrossRefGoogle ScholarPubMed
Steegers-Theunissen, RP, Obermann-Borst, SA, Kremer, D, et al. Periconceptional maternal folic acid use of 400 microg per day is related to increased methylation of the IGF2 gene in the very young child. Plos One. 2009; 4(11), e7845.CrossRefGoogle Scholar
Tibbetts, AS, Appling, DR. Compartmentalization of Mammalian folate-mediated one-carbon metabolism. Annu Rev Nutr. 2010; 30(1), 57–81.CrossRefGoogle ScholarPubMed
Locasale, JW. Serine, glycine and one-carbon units: cancer metabolism in full circle. Nat Rev Cancer. 2013; 13(8), 572–583.CrossRefGoogle ScholarPubMed
Shane, B. Folate and vitamin B12 metabolism: overview and interaction with riboflavin, vitamin B6, and polymorphisms. Food Nutr Bull. 2008; 29(2 Suppl), S5–S19.CrossRefGoogle ScholarPubMed
Ducker, GS, Rabinowitz, JD. One-carbon metabolism in health and disease. Cell Metab. 2017; 25(1), 27–42.CrossRefGoogle ScholarPubMed
Davis, CD, Uthus, EO. DNA methylation, cancer susceptibility, and nutrient interactions. Exp Biol Med (Maywood). 2004; 229(10), 988–995.CrossRefGoogle ScholarPubMed
Liu, Z, Jin, X, Pi, W, Liu, S. Folic acid inhibits nasopharyngeal cancer cell proliferation and invasion via activation of FRα/ERK1/2/TSLC1 pathway. Biosci Rep. 2017; 37(6), 87.CrossRefGoogle ScholarPubMed
Ramakrishnan, U, Grant, F, Goldenberg, T, Zongrone, A, Martorell, R. Effect of women’s nutrition before and during early pregnancy on maternal and infant outcomes: a systematic review. Paediatr Perinat Epidemiol. 2012; 26(Suppl 1), 285–301.CrossRefGoogle ScholarPubMed
Palmer, AC. Nutritionally mediated programming of the developing immune system. Adv Nutr. 2011; 2(5), 377–395.CrossRefGoogle ScholarPubMed
Gilman, EA, Wilson, LM, Kneale, GW, Waterhouse, JA. Childhood cancers and their association with pregnancy drugs and illnesses. Paediatr Perinat Epidemiol. 1989; 3(1), 66–94.CrossRefGoogle ScholarPubMed
Milne, E, Greenop, KR, Scott, RJ, et al. Parental prenatal smoking and risk of childhood acute lymphoblastic leukemia. Am J Epidemiol. 2012; 175(1), 43–53.CrossRefGoogle ScholarPubMed
Guerquin, MJ, Duquenne, C, Coffigny, H, et al. Sex-specific differences in fetal germ cell apoptosis induced by ionizing radiation. Hum Reprod. 2009; 24(3), 670–678.CrossRefGoogle ScholarPubMed
Ren, ZF, Liu, WS, Qin, HD, et al. Effect of family history of cancers and environmental factors on risk of nasopharyngeal carcinoma in Guangdong, China. Cancer Epidemiol. 2010; 34(4), 419–424.CrossRefGoogle ScholarPubMed
Jia, WH, Feng, BJ, Xu, ZL, et al. Familial risk and clustering of nasopharyngeal carcinoma in Guangdong, China. Cancer. 2004; 101(2), 363–369.CrossRefGoogle ScholarPubMed