Hostname: page-component-cd9895bd7-jkksz Total loading time: 0 Render date: 2024-12-23T11:59:30.171Z Has data issue: false hasContentIssue false
  • English
  • Français

Prenatal and early-life predictors of atopy and allergic disease in Canadian children: results of the Family Atherosclerosis Monitoring In earLY life (FAMILY) Study

Published online by Cambridge University Press:  25 July 2016

T. Batool ,
P. L. Reece ,
K. M. Schulze ,
K. M. Morrison ,
S. A. Atkinson ,
S. S. Anand ,
K. K. Teo ,
J. A. Denburg ,
M. M. Cyr  and
the FAMILY Study Investigators
T. Batool*
Affiliation:
Department of Medicine, McMaster University, Hamilton, ON, Canada
P. L. Reece
Affiliation:
Department of Medicine, McMaster University, Hamilton, ON, Canada
K. M. Schulze
Affiliation:
Population Health Research Institute, McMaster University, Hamilton, ON, Canada
K. M. Morrison
Affiliation:
Population Health Research Institute, McMaster University, Hamilton, ON, Canada Department of Pediatrics, Hamilton Health Sciences and McMaster University, Hamilton, ON, Canada
S. A. Atkinson
Affiliation:
Department of Pediatrics, Hamilton Health Sciences and McMaster University, Hamilton, ON, Canada
S. S. Anand
Affiliation:
Department of Medicine, McMaster University, Hamilton, ON, Canada Population Health Research Institute, McMaster University, Hamilton, ON, Canada Department of Clinical Epidemiology, McMaster University, Hamilton, ON, Canada
K. K. Teo
Affiliation:
Department of Medicine, McMaster University, Hamilton, ON, Canada Population Health Research Institute, McMaster University, Hamilton, ON, Canada
J. A. Denburg
Affiliation:
Department of Medicine, McMaster University, Hamilton, ON, Canada
M. M. Cyr
Affiliation:
Department of Medicine, McMaster University, Hamilton, ON, Canada
the FAMILY Study Investigators
Affiliation:
Population Health Research Institute, McMaster University, Hamilton, ON, Canada
*
*Address for correspondence: T. Batool, 105-300 Rossland Road East, Ajax, ON L1Z 0M1, Canada. (Email [email protected])
Get access Rights & Permissions [Opens in a new window]

Abstract

Prenatal and early-life environmental exposures play a key role in the development of atopy and allergic disease. The Family Atherosclerosis Monitoring In earLY life Study is a general, population-based Canadian birth cohort that prospectively evaluated prenatal and early-life traits and their association with atopy and/or allergic disease. The study population included 901 babies, 857 mothers and 530 fathers. Prenatal and postnatal risk factors were evaluated through questionnaires collected during the antenatal period and at 1 year. The end points of atopy and allergic diseases in infants were evaluated through questionnaires and skin prick testing. Key outcomes included atopy (24.5%), food allergy (17.5%), cow’s milk allergy (4.8%), wheezing (18.6%) and eczema (16%). The association between infant antibiotic exposure [odds ratio (OR): 2.04, 95% confidence interval (CI): 1.45–2.88] and increased atopy was noted in the multivariate analysis, whereas prenatal maternal exposure to dogs (OR: 0.60, 95% CI: 0.42–0.84) and acetaminophen (OR: 0.68, 95% CI: 0.51–0.92) was associated with decreased atopy. This population-based birth cohort in Canada demonstrated high rates of atopy, food allergy, wheezing and eczema. Several previously reported and some novel prenatal and postnatal exposures were associated with atopy and allergic diseases at 1 year of age.

Keywords

allergy/atopyhumannewborn childrenoutcome/systempregnancy
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 7 , Issue 6: Themed Issue: Developmental Origins of Adult Mental Health and Illness , December 2016 , pp. 665 - 671
Check for updates
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2016 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Bousquet, J, Anto, J, Auffray, C. MeDALL (Mechanisms of the Development of ALLergy): an integrated approach from phenotypes to systems medicine. Allergy. 2011; 66, 596–604.Google Scholar
2. Henderson, AJ, Warner, JO, et al. Fetal origins of asthma. Semin Fetal Neonatal Med. 2012; 17, 82–91.Google Scholar
3. Granum, B, Lovik, M. The effect of particles on allergic immune responses. Toxicol Sci. 2002; 65, 7–17.Google Scholar
4. Chatzi, L, Torrent, M, Romieu, I, et al. Mediterranean diet in pregnancy is protective for wheeze and atopy in childhood. Thorax. 2008; 63, 507–513.Google Scholar
5. Morrison, KM, Anand, SS, Yusuf, S, et al. Maternal and pregnancy related predictors of cardiometabolic traits in newborns. PLoS One. 2013; 8, e55815.Google Scholar
6. Morrison, KM, Atkinson, SA, Yusuf, S, et al. The Family Atherosclerosis Monitoring In earLY life (FAMILY) study: rationale, design, and baseline data of a study examining the early determinants of atherosclerosis. Am Heart J. 2009; 158, 533–539.Google Scholar
7. Skassa-Brociek, W, Manderscheid, JC, Michel, FB, et al. Skin test reactivity to histamine from infancy to old age. J Allergy Clin Immunol. 1987; 80, 711–716.Google Scholar
8. Prescott, SL. Early-life environmental determinants of allergic diseases and the wider pandemic of inflammatory noncommunicable diseases. J Allergy Clin Immunol. 2013; 131, 23–30.Google Scholar
9. Soller, L, et al. Overall prevalence of self-reported food allergy in Canada. J Allergy Clin Immunol. 2012; 130, 986–988.Google Scholar
10. Pelucchi, C, Galeone, C, Bach, JF, et al. Pet exposure and risk of atopic dermatitis at the pediatric age: a meta-analysis of birth cohort studies. J Allergy Clin Immunol. 2013; 132, 616–622.e7.CrossRefGoogle ScholarPubMed
11. Bufford, JD, Reardon, SL, Li, Z, et al. Effects of dog ownership in early childhood on immune development and atopic diseases. Clin Exp Allergy. 2008; 38, 1635–1643.Google Scholar
12. Azad, MB, Konya, T, Guttman, DS, et al. Infant gut microbiota and the hygiene hypothesis of allergic disease: impact of household pets and siblings on microbiota composition and diversity. Allergy Asthma Clin Immunol. 2013; 9, 15.Google Scholar
13. Kramer, MS, Aboud, F, Mironova, E, et al. Breastfeeding and allergy: the evidence. Ann Nutr Metab. 2011; 59(Suppl. 1), 20–26.Google Scholar
14. Marie-Josée, Martel, Évelyne, Rey, Jean-Luc, Malo, et al. Determinants of the incidence of childhood asthma: a two-stage case-control study. Am J Epidemiol. 2009; 169, 195–205.Google Scholar
15. Ong, MS, Umetsu, DT, Mandl, KD, et al. Consequences of antibiotics and infections in infancy: bugs, drugs, and wheezing. Ann Allergy Asthma Immunol. 2014; 112, 441–445.Google Scholar
16. Tsakok, T, McKeever, TM, Yeo, L, et al. Does early life exposure to antibiotics increase the risk of eczema? A systematic review. Br J Dermatol. 2013; 169, 983–991.Google Scholar
17. Russell, SL, Gold, MJ, Hartmaan, M, et al. Early life antibiotic-driven changes in microbiota enhance susceptibility to allergic asthma. 2012; 13, 440–447.Google Scholar
18. Kozyrskyi, AL, Bahreinian, S, Azad, MB, et al. Early life exposures: impact on asthma and allergic disease. Curr Opin Allergy Clin Immunol. 2011; 11, 400–406.Google Scholar
19. Shreiner, A, Huffnagle, GB, Noverr, MC, et al. The ‘microflora hypothesis’ of allergic disease. Adv Exp Med Biol. 2008; 635, 113–134.Google Scholar
20. Persaud, PR, Azad, MB, Chari, RS, et al. Perinatal antibiotic exposure of neonates in Canada and associated risk factors: a population-based study. J Matern Fetal Neonatal Med. 2015; 28, 1190–1195.Google Scholar
21. Arrieta, MC, Stiemsma, TL, Dimitriu, AP, et al. Early infancy microbial and metabolic alterations affect risk of childhood asthma. Sci Transl Med. 2015; 7, 307ra152.Google Scholar
22. Mai, XM, Kull, I, Wickman, M, et al. Antibiotic use in early life and development of allergic diseases: respiratory infection as the explanation. Clin Exp Allergy. 2010; 40, 1230–1237.CrossRefGoogle ScholarPubMed
23. Hancox, RJ, Subbarao, P, Sears, MR, et al. Relevance of birth cohorts to assessment of asthma persistence. Curr Allergy Asthma Rep. 2012; 12, 175–184.Google Scholar
24. Goksor, E, Amark, M, ALM, B, et al. The impact of pre- and post-natal smoke exposure on future asthma and bronchial hyper-responsiveness. Acta Paediatr. 2007; 96, 1030–1035.Google Scholar
25. Jakkola, JJ, Kosheleva, AA, Katsnelson, BA, et al. Prenatal and postnatal tobacco smoke exposure and respiratory health in Russian children. Respir Res. 2006; 7, 48.Google Scholar
26. Simons, E, To, T, Moineddin, R, et al. Maternal second-hand smoke exposure in pregnancy is associated with childhood asthma development. J Allergy Clin Immunol Pract. 2014; 2, 201–207.Google Scholar
27. Shaheen, SO, Newson, RB, Sherriff, A, et al. Paracetamol use in pregnancy and wheezing in early childhood. Thorax. 2002; 57, 958–963.Google Scholar
28. Shaheen, SO, Newson, RB, Henderson, AJ, et al. Prenatal paracetamol exposure and risk of asthma and elevated immunoglobulin E in childhood. Clin Exp Allergy. 2005; 35, 18–25.Google Scholar
29. Wickens, K, Beasley, R, Town, I, et al. The effects of early and late paracetamol exposure on asthma and atopy: a birth cohort. Clin Exp Allergy. 2011; 41, 399–406.Google Scholar
30. Wang, JY, Liu, LF, Chen, CY, et al. Acetaminophen and/or antibiotic use in early life and the development of childhood allergic diseases. Int J Epidemiol. 2013; 42, 1087–1099.Google Scholar
31. Almqvist, C, Wettermark, B, Hedlin, G, et al. Antibiotics and asthma medication in a large register-based cohort study – confounding, cause and effect. Clin Exp Allergy. 2012; 42, 104–111.Google Scholar