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Premature guinea pigs: a new paradigm to investigate the late-effects of preterm birth

Published online by Cambridge University Press:  12 December 2014

M. Berry ,
C. Gray ,
K. Wright ,
R. Dyson  and
I. Wright
M. Berry*
Affiliation:
Centre for Translational Physiology, University of Otago, Wellington, New Zealand Department of Paediatrics and Child Health, University of Otago, Wellington, New Zealand
C. Gray
Affiliation:
Centre for Translational Physiology, University of Otago, Wellington, New Zealand Department of Paediatrics and Child Health, University of Otago, Wellington, New Zealand Liggins Institute, University of Auckland, Auckland, New Zealand
K. Wright
Affiliation:
Biomedical Research Unit, University of Otago, Wellington, New Zealand
R. Dyson
Affiliation:
Department of Paediatrics, Graduate School of Medicine and IHMRI, University of Wollongong, Wollongong, NSW, Australia
I. Wright
Affiliation:
Department of Paediatrics, Graduate School of Medicine and IHMRI, University of Wollongong, Wollongong, NSW, Australia
*
*Address for correspondence: M. Berry, Department of Paediatrics and Child Health, University of Otago, Wellington South 6242, PO Box 7343, New Zealand. (Email [email protected])
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Abstract

Preterm birth is common and the associated short-term morbidity well described. The adult-onset consequences of preterm birth are less clear, but cardiovascular and metabolic health may be adversely affected. Although large animal models of preterm birth addressing important short-term issues exist, long-term studies are hampered by significant logistical constraints. Current small animal models of prematurity require terminal caesarean section of the mother; both caesarean birth and early maternal care modify offspring adult cardio-metabolic function.

We describe a novel method for inducing preterm labour in guinea pigs. With support comparable to that received by moderately preterm human infants, preterm pups are viable. Growth trajectories between preterm and term-born pups differ significantly; between term equivalent age and weaning ex-preterm animals demonstrate increased weight and ponderal index.

We believe this novel paradigm will significantly improve our ability to investigate the cardio-metabolic sequelae of preterm birth throughout the life course and into the second generation.

Keywords

animal modelsdevelopmental origins of health and diseasepreterm birthtranslational biomedical research
Type
Brief Report
Information
Journal of Developmental Origins of Health and Disease , Volume 6 , Issue 2 , April 2015 , pp. 143 - 148
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Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2014 

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References

1. Blencowe, H, Cousens, S, Oestergaard, MZ, et al. National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications. Lancet. 2012; 379, 2162–2172.CrossRefGoogle ScholarPubMed
2. Doyle, LW. Evaluation of neonatal intensive care for extremely low birth weight infants in Victoria over two decades: I. Effectiveness. Pediatrics. 2004; 113(3 Pt 1), 505–509.CrossRefGoogle ScholarPubMed
3. Johansson, S, Iliadou, A, Bergvall, N, et al. Risk of high blood pressure among young men increases with the degree of immaturity at birth. Circulation. 2005; 112, 3430–3436.CrossRefGoogle ScholarPubMed
4. Bonamy, AK, Bendito, A, Martin, H, et al. Preterm birth contributes to increased vascular resistance and higher blood pressure in adolescent girls. Pediatr Res. 2005; 58, 845–849.CrossRefGoogle ScholarPubMed
5. Crump, C, Winkleby, MA, Sundquist, K, Sundquist, J. Risk of hypertension among young adults who were born preterm: a Swedish national study of 636,000 births. Am J Epidemiol. 2011; 173, 797–803.CrossRefGoogle ScholarPubMed
6. Lewandowski, AJ, Bradlow, WM, Augustine, D, et al. Right ventricular systolic dysfunction in young adults born preterm. Circulation. 2013; 128, 713–720.CrossRefGoogle ScholarPubMed
7. Lewandowski, AJ, Augustine, D, Lamata, P, et al. Preterm heart in adult life: cardiovascular magnetic resonance reveals distinct differences in left ventricular mass, geometry, and function. Circulation. 2013; 127, 197–206.CrossRefGoogle ScholarPubMed
8. Schubert, U, Muller, M, Bonamy, AK, Abdul-Khaliq, H, Norman, M. Aortic growth arrest after preterm birth: a lasting structural change of the vascular tree. J Dev Orig Health Dis. 2011; 2, 218–225.CrossRefGoogle ScholarPubMed
9. Bassareo, PP, Fanos, V, Puddu, M, et al. Significant QT interval prolongation and long QT in young adult ex-preterm newborns with extremely low birth weight. J Matern Fetal Neonatal Med. 2011; 24, 1115–1118.CrossRefGoogle ScholarPubMed
10. Tinnion, R, Gillone, J, Cheetham, T, Embleton, N. Preterm birth and subsequent insulin sensitivity: a systematic review. Arch Dis Child. 2014; 99, 362–368.CrossRefGoogle ScholarPubMed
11. Glinianaia, SV, Ghosh, R, Rankin, J, et al. No improvement in socioeconomic inequalities in birthweight and preterm birth over four decades: a population-based cohort study. BMC Public Health. 2013; 13, 345.CrossRefGoogle ScholarPubMed
12. Sangild, PT, Thymann, T, Schmidt, M, et al. Invited review: the preterm pig as a model in pediatric gastroenterology. J Anim Sci. 2013; 91, 4713–4729.CrossRefGoogle Scholar
13. Berry, M, Jaquiery, A, Oliver, M, Harding, J, Bloomfield, F. Preterm birth has sex-specific effects on autonomic modulation of heart rate variability in adult sheep. PLoS One. 2013; 8, e85468.CrossRefGoogle ScholarPubMed
14. Kind, KL, Clifton, PM, Grant, PA, et al. Effect of maternal feed restriction during pregnancy on glucose tolerance in the adult guinea pig. Am J Physiol Regul Integr Comp Physiol. 2003; 284, R140–R152.CrossRefGoogle ScholarPubMed
15. Hess, P, Rey, M, Wanner, D, Steiner, B, Clozel, M. Measurements of blood pressure and electrocardiogram in conscious freely moving guineapigs: a model for screening QT interval prolongation effects. Lab Anim. 2007; 41, 470–480.CrossRefGoogle Scholar
16. Leite, JO, DeOgburn, R, Ratliff, JC, et al. Low-carbohydrate diet disrupts the association between insulin resistance and weight gain. Metabolism. 2009; 58, 1116–1122.CrossRefGoogle ScholarPubMed
17. Dyson, RM, Palliser, HK, Kelleher, MA, Hirst, JJ, Wright, IMR. The guinea pig as an animal model for studying perinatal changes in microvascular function. Pediatr Res. 2012; 71, 20–24.CrossRefGoogle ScholarPubMed
18. Matthews, PA, Samuelsson, AM, Seed, P, et al. Fostering in mice induces cardiovascular and metabolic dysfunction in adulthood. J Physiol. 2011; 589(Pt 16), 3969–3981.CrossRefGoogle ScholarPubMed
19. Hennessy, MB. Filial attachment and its disruption: insights from the guinea pig. Dev Psychobiol. 2014.CrossRefGoogle ScholarPubMed
20. American College of Obstetricians and Gynecologists. Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Obstet Gynecol. 2007; 109, 189–190.CrossRefGoogle Scholar
21. Owen, D, Matthews, SG. Prenatal glucocorticoid exposure alters hypothalamic-pituitary-adrenal function in juvenile guinea pigs. J Neuroendocrinol. 2007; 19, 172–180.CrossRefGoogle ScholarPubMed
22. Sosenko, IR, Frank, L. Lung development in the fetal guinea pig: surfactant, morphology, and premature viability. Pediatr Res. 21, 427–431.CrossRefGoogle Scholar
23. Martin, JA, Hamilton, BE, Osterman, MJK, Curtin, SC, Mathews, TJ. Births: Final Data for 2012. In National Vital Statistics Reports, 2013, pp. 1–87. Hyattsville, MD.Google Scholar
24. Dalziel, SR, Parag, V, Rodgers, A, Harding, JE. Cardiovascular risk factors at age 30 following pre-term birth. Int J Epidemiol. 2007; 36, 907–915.CrossRefGoogle ScholarPubMed
25. Heinzerling, NP, Liedel, JL, Welak, SR, et al. Intestinal alkaline phosphatase is protective to the preterm rat pup intestine. J Pediatr Surg. 2014; 49, 954–960, discussion 960.CrossRefGoogle Scholar
26. Hansen, AK, Wisborg, K, Uldbjerg, N, Henriksen, TB. Elective caesarean section and respiratory morbidity in the term and near-term neonate. Acta Obstet Gynecol Scand. 2007; 86, 389–394.CrossRefGoogle ScholarPubMed
27. De Matteo, R, Blasch, N, Stokes, V, Davis, P, Harding, R. Induced preterm birth in sheep: a suitable model for studying the developmental effects of moderately preterm birth. Reprod Sci. 2010; 17, 724–733.CrossRefGoogle ScholarPubMed