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Neonatal zingerone protects against the development of high-fructose diet-induced metabolic syndrome in adult Sprague-Dawley rats

Published online by Cambridge University Press:  05 June 2020

N. Muhammad Open the ORCID record for N. Muhammad [Opens in a new window] ,
B. W. Lembede  and
K. H Erlwanger Open the ORCID record for K. H Erlwanger [Opens in a new window]
N. Muhammad*
Affiliation:
School of Physiology, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa Department of Physiology, College of Health Sciences, Federal University Birnin Kebbi, Birnin Kebbi, Nigeria
B. W. Lembede
Affiliation:
School of Physiology, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa
K. H Erlwanger
Affiliation:
School of Physiology, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa
*
Address for correspondence: N. Muhammad, School of Physiology, Faculty of Health Sciences, University of Witwatersrand, 7 York Road, Parktown, Johannesburg2193, South Africa. Email: [email protected]
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Abstract

During the early postnatal period, dietary manipulations can alter the developmental trajectory of the growing offspring, causing beneficial or adverse health outcomes later in adult life. We investigated the potential preventive effects of neonatal zingerone intake on the development of fructose-induced metabolic derangements in rats.

Four-day old male and female Sprague-Dawley rat pups (n = 79) were randomly grouped and administered: 10 ml/kg body weight (bwt) of distilled water (W), 10 ml/kg bwt 20% fructose solution (FS), 10 ml/kg bwt fructose solution + 40 mg/kg bwt of zingerone in distilled water (ZF) or 40 mg/kg bwt of zingerone in distilled water (ZW) pre-weaning. After weaning, W and ZW continued on unlimited tap water, while FS and ZF continued on unlimited fructose solution for 10 weeks. Body mass and food and fluid intake were evaluated, plasma was collected for metabolic assays and visceral fat was quantified.

Food intake was decreased, fructose and overall caloric intake were increased due to fructose feeding in both sexes (P < 0.05). When compared with the controls, the high-fructose diet significantly raised the terminal body masses of females (P < 0.0001), concentrations of triglycerides, total cholesterol, LDL-c, TG:HDL-c ratio and visceral fat mass relative to bwt in both sexes (P < 0.05). Zingerone prevented (P < 0.05) the fructose-induced increase in body mass (females) and hypercholesterolemia (both sexes). Levels of HDL-c, glycaemic parameters and adiponectin were not affected by the interventions (P > 0.05). Sex-related differences were observed in food, fluid and caloric intake, terminal mass, cholesterol subtypes and visceral fat percentage (P < 0.05).

Zingerone could be used strategically in the neonatal phase as a prophylatic management of high-fructose diet-induced metabolic syndrome.

Keywords

Fructosemetabolic dysfunctionzingeroneneonataldyslipidaemiaobesity
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 12 , Issue 4 , August 2021 , pp. 671 - 679
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Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2020

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