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Maternal undernutrition programs the apelinergic system of adipose tissue in adult male rat offspring

Published online by Cambridge University Press:  04 January 2017

S. Lecoutre ,
L. Marousez ,
A. Drougard ,
C. Knauf ,
C. Guinez ,
D. Eberlé ,
C. Laborie ,
D. Vieau ,
J. Lesage  and
C. Breton
S. Lecoutre
Affiliation:
EA4489, Équipe Malnutrition Maternelle et Programmation des Maladies Métaboliques, Univ. Lille, Lille, France
L. Marousez
Affiliation:
EA4489, Équipe Malnutrition Maternelle et Programmation des Maladies Métaboliques, Univ. Lille, Lille, France
A. Drougard
Affiliation:
European Associated Laboratory NeuroMicrobiota (INSERM/UCL), Team 3, IRSD, INSERM U1220, Toulouse, France
C. Knauf
Affiliation:
European Associated Laboratory NeuroMicrobiota (INSERM/UCL), Team 3, IRSD, INSERM U1220, Toulouse, France
C. Guinez
Affiliation:
EA4489, Équipe Malnutrition Maternelle et Programmation des Maladies Métaboliques, Univ. Lille, Lille, France
D. Eberlé
Affiliation:
EA4489, Équipe Malnutrition Maternelle et Programmation des Maladies Métaboliques, Univ. Lille, Lille, France
C. Laborie
Affiliation:
EA4489, Équipe Malnutrition Maternelle et Programmation des Maladies Métaboliques, Univ. Lille, Lille, France
D. Vieau
Affiliation:
EA4489, Équipe Malnutrition Maternelle et Programmation des Maladies Métaboliques, Univ. Lille, Lille, France
J. Lesage
Affiliation:
EA4489, Équipe Malnutrition Maternelle et Programmation des Maladies Métaboliques, Univ. Lille, Lille, France
C. Breton*
Affiliation:
EA4489, Équipe Malnutrition Maternelle et Programmation des Maladies Métaboliques, Univ. Lille, Lille, France
*
*Address for correspondence: C. Breton, EA4489, Équipe Malnutrition Maternelle et Programmation des Maladies Métaboliques, Univ. Lille, F59000 Lille, France. (Email [email protected])
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Abstract

Based on the Developmental Origin of Health and Disease concept, maternal undernutrition has been shown to sensitize adult offspring to metabolic pathologies such as obesity. Using a model of maternal 70% food restriction in pregnant female rats throughout gestation (called FR30), we previously reported that obesity-prone adult male rat offspring displayed hyperleptinemia with modifications in leptin and leptin receptor messenger RNA (mRNA) levels in white adipose tissue (WAT). Apelin is a member of the adipokine family that regulates various aspects of energy metabolism and WAT functionality. We investigated whether apelin and its receptor APJ could be a target of maternal undernutrition. Adult male rat offspring from FR30 dams showed increased plasma apelin levels and apelin gene expression in WAT. Post-weaning high-fat diet led to marked increase in APJ mRNA and protein levels in offspring’s WAT. We demonstrate that maternal undernutrition and post-weaning diet have long-term consequences on the apelinergic system of adult male rat offspring.

Keywords

adipogenesisapelinAPJfetal programmingHF diet
Type
Rapid Communication
Information
Journal of Developmental Origins of Health and Disease , Volume 8 , Issue 1 , February 2017 , pp. 3 - 7
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2017 

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