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Maternal diet-induced obesity in swine with leptin resistance modifies puberty and pregnancy outputs of the adult offspring

Published online by Cambridge University Press:  16 May 2013

A. Gonzalez-Bulnes ,
S. Astiz ,
R. Sanchez-Sanchez ,
M. Perez-Solana  and
E. Gomez-Fidalgo
A. Gonzalez-Bulnes*
Affiliation:
Department of Animal Reproduction, INIA, Madrid, Spain
S. Astiz
Affiliation:
Department of Animal Reproduction, INIA, Madrid, Spain
R. Sanchez-Sanchez
Affiliation:
Department of Animal Reproduction, INIA, Madrid, Spain
M. Perez-Solana
Affiliation:
Department of Animal Reproduction, INIA, Madrid, Spain
E. Gomez-Fidalgo
Affiliation:
Department of Animal Reproduction, INIA, Madrid, Spain
*
Address for correspondence: A. Gonzalez-Bulnes, Animal Reproduction Department, INIA, Avda. Puerta de Hierro s/n. 28040-Madrid, Spain. Email [email protected]
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Abstract

The assessment of reproductive features (puberty, fertility and prolificacy) in female Iberian pigs indicates that exposition to intrauterine maternal malnutrition, either by deficiency or excess, is associated with juvenile obesity and a significantly earlier age of puberty onset. At adulthood, prenatal exposition to undernutrition affects reproductive outputs by diminishing prolificacy, an effect that was not found in females exposed to prenatal overnutrition.

Keywords

fertilityfoetal programmingnutritionprolificacypubertyswine
Type
Brief Report
Information
Journal of Developmental Origins of Health and Disease , Volume 4 , Issue 4 , August 2013 , pp. 290 - 295
Copyright
Copyright © Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2013 

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