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Influence of prenatal stress on metabolic abnormalities induced by postnatal intake of a high-fat diet in BALB/c mice

Published online by Cambridge University Press:  29 October 2020

Yamila Raquel Juárez ,
Sofía Quiroga ,
Andrés Prochnik ,
Miriam Wald ,
Mariana Lorena Tellechea ,
Ana María Genaro  and
Adriana Laura Burgueño Open the ORCID record for Adriana Laura Burgueño [Opens in a new window]
Yamila Raquel Juárez
Affiliation:
Instituto de Investigaciones Biomédicas, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) – Pontificia Universidad Católica Argentina, Alicia Moreau de Justo 1600, Buenos AiresC1107AFF, Argentina
Sofía Quiroga
Affiliation:
Instituto de Investigaciones Biomédicas, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) – Pontificia Universidad Católica Argentina, Alicia Moreau de Justo 1600, Buenos AiresC1107AFF, Argentina
Andrés Prochnik
Affiliation:
Instituto de Investigaciones Biomédicas, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) – Pontificia Universidad Católica Argentina, Alicia Moreau de Justo 1600, Buenos AiresC1107AFF, Argentina
Miriam Wald
Affiliation:
Instituto de Investigaciones Biomédicas, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) – Pontificia Universidad Católica Argentina, Alicia Moreau de Justo 1600, Buenos AiresC1107AFF, Argentina
Mariana Lorena Tellechea
Affiliation:
Centro de Investigaciones Endocrinológicas “Dr. César Bergadá” (CEDIE), CONICET – FEI – División de Endocrinología, Hospital de Niños R. Gutiérrez, Gallo 1330, C1425EFDBuenos Aires, Argentina
Ana María Genaro
Affiliation:
Instituto de Investigaciones Biomédicas, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) – Pontificia Universidad Católica Argentina, Alicia Moreau de Justo 1600, Buenos AiresC1107AFF, Argentina Departamento de Farmacología, Facultad de Medicina, Universidad de Buenos Aires. Paraguay 2151 Piso 15, Buenos AiresC1121ABG, Argentina
Adriana Laura Burgueño*
Affiliation:
Instituto de Investigaciones Biomédicas, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) – Pontificia Universidad Católica Argentina, Alicia Moreau de Justo 1600, Buenos AiresC1107AFF, Argentina
*
Address for correspondence: Burgueño Adriana Laura, Instituto de Investigaciones Biomédicas, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) – Pontificia Universidad Católica Argentina, Av. Alicia Moreau de Justo 1600, Piso 3, Buenos AiresC1107AFF, Argentina. Email: [email protected]
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Abstract

Prenatal insults during fetal development result in increased likelihood of developing chronic disease. Obesity, the biggest risk factor for the development of metabolic disease, is affected by several genetic and environmental factors. High-fat diet (HFD) consumption is usually linked with the development of obesity. The main goal of this study was to analyze the impact of the exposure to a HFD in prenatally stressed animals. For this purpose, we subjected pregnant BALB/c mice to restraint stress for 2 h a day between gestational day (GD) 14 and GD 21. Prenatally stressed and control offspring of both sexes were postnatally exposed to a HFD for 24 weeks. We found that prenatal stress (PS) per se produced disturbances in males such as increased total blood cholesterol and triglycerides, with a decrease in mRNA expression of sirtuin-1. When these animals were fed a HFD, we observed a rise in glucose and insulin levels and an increase in visceral adipose tissue gene expression of leptin, resistin, and interleukin-1 beta. Although females proved to be more resilient to PS consequences, when they were fed a HFD, they showed significant metabolic impairment. In addition to the changes observed in males, females also presented an increase in body weight and adiposity and a rise in cholesterol levels.

Keywords

Prenatal stressobesitymetabolismgene expression
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 12 , Issue 5 , October 2021 , pp. 721 - 730
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Copyright
© The Author(s), 2020. Published by Cambridge University Press in association with International Society for Developmental Origins of Health and Disease

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Footnotes

*

These authors contributed equally to this work.

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