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The impact of maternal periodontitis in the development of asthma in the offspring

Published online by Cambridge University Press:  21 April 2020

Grazielle Rodrigues ,
Alexandre do Valle Wuo ,
Simone Klein ,
Patrícia de Almeida ,
Amilcar Sabino Damazo ,
Rodrigo Labat Marcos ,
Anna Carolina Ratto Tempestini Horliana  and
Adriana Lino-dos-Santos-Franco Open the ORCID record for Adriana Lino-dos-Santos-Franco [Opens in a new window]
Grazielle Rodrigues
Affiliation:
Department of Biophotonics Applied to Health Sciences, University Nove de Julho (UNINOVE), São Paulo, Brazil
Alexandre do Valle Wuo
Affiliation:
Department of Biophotonics Applied to Health Sciences, University Nove de Julho (UNINOVE), São Paulo, Brazil
Simone Klein
Affiliation:
Department of Biophotonics Applied to Health Sciences, University Nove de Julho (UNINOVE), São Paulo, Brazil
Patrícia de Almeida
Affiliation:
Department of Biophotonics Applied to Health Sciences, University Nove de Julho (UNINOVE), São Paulo, Brazil
Amilcar Sabino Damazo
Affiliation:
Department of Health Sciences, Faculty of Medicine, Mato Grosso, Brazil
Rodrigo Labat Marcos
Affiliation:
Department of Biophotonics Applied to Health Sciences, University Nove de Julho (UNINOVE), São Paulo, Brazil
Anna Carolina Ratto Tempestini Horliana
Affiliation:
Department of Biophotonics Applied to Health Sciences, University Nove de Julho (UNINOVE), São Paulo, Brazil
Adriana Lino-dos-Santos-Franco*
Affiliation:
Department of Biophotonics Applied to Health Sciences, University Nove de Julho (UNINOVE), São Paulo, Brazil
*
Address for correspondence: Adriana Lino-dos-Santos-Franco, PhD, Department of Biophotonics Applied to Health Sciences, University Nove de Julho (UNINOVE), Rua Vergueiro, 239/245, São Paulo, SPCEP 01504-000, Brazil. Email: [email protected]
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Abstract

Clinical and experimental studies show an association between maternal periodontitis and adverse outcomes during gestation. On the other hand, there were no studies evaluating the impact of maternal periodontitis on the offspring. Thus, our objective was to investigate the repercussion of maternal periodontitis on the development of asthma in the offspring. Pregnant rats were submitted or not to periodontitis by ligature technique. Thirty days after birth, the puppies were sensitized and challenged with ovalbumin (OVA) in order to induce asthmatic response. Our results showed that maternal periodontitis reduced cellular infiltrate in the parenchyma of offspring, tracheal responsiveness, lung edema, and anti-OVA antibodies, without alter mucus as well as cytokines production. We concluded that periodontitis has relevant impact on the offspring’s immune system, blunting the response to allergic and inflammatory stimulus. This study shows the important role of oral health during pregnancy and opens possibilities for future studies in order to explain the effects of periodontitis during pregnancy in the offspring.

Keywords

Periodontitispregnancyallergic lung inflammationcytokinesoffspringrats
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 12 , Issue 2 , April 2021 , pp. 293 - 299
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Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2020

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