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(-)-Epicatechin reduces adiposity in male offspring of obese rats

Published online by Cambridge University Press:  10 June 2019

Sergio De los Santos ,
Luis Antonio Reyes-Castro ,
Ramón Mauricio Coral-Vázquez ,
Juan Pablo Méndez ,
Marcela Leal-García ,
Elena Zambrano  and
Patricia Canto Open the ORCID record for Patricia Canto [Opens in a new window]
Sergio De los Santos
Affiliation:
Unidad de Investigación en Obesidad, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, México
Luis Antonio Reyes-Castro
Affiliation:
Departamento de Biología de Reproducción, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán,”Ciudad de México, México
Ramón Mauricio Coral-Vázquez
Affiliation:
Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Ciudad de México, México Subdirección de Enseñanza e Investigación, Centro Médico Nacional “20 de Noviembre,”Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Ciudad de México, México
Juan Pablo Méndez
Affiliation:
Unidad de Investigación en Obesidad, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, México Subdirección de Investigación Clínica, Dirección de Investigación, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán,”Ciudad de México, México
Marcela Leal-García
Affiliation:
Unidad de Investigación en Obesidad, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, México
Elena Zambrano
Affiliation:
Departamento de Biología de Reproducción, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán,”Ciudad de México, México
Patricia Canto*
Affiliation:
Unidad de Investigación en Obesidad, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, México Subdirección de Investigación Clínica, Dirección de Investigación, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán,”Ciudad de México, México
*
Address for correspondence: Patricia Canto, Unidad de Investigación en Obesidad, Facultad de Medicina, Universidad Nacional Autónoma de México & Subdirección de Investigación Clínica, Dirección de Investigación, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”, Vasco de Quiroga No. 15, Col. Sección XVI, Delegación Tlalpan, CP 14000, Mexico, D.F., México. Emails: [email protected]; [email protected]
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Abstract

Objective:

To determine whether (-)-epicatechin (Epi) could decrease visceral adipose tissue and improve the metabolic profile of male offspring rats, after maternal obesity was induced by a high-fat diet (HFD).

Design:

Maternal obesity in albino Wistar rats was induced with a HFD, whereas male offspring were fed with chow diet throughout the study. Eight male offspring per group, from different litters, were randomly assigned to the experimental or to the control groups. In the experimental group, Epi was administered at a dose of 1 mg/kg of body weight to the male offspring twice daily for two weeks, beginning at postnatal day (PND).

Main measures:

Weight of visceral adipose tissue, adipocyte size, and several metabolic parameters.

Results:

Epi administration in the male offspring induced a significant decrease in the amount of visceral fat (11.61 g less, P < 0.05) and in the size of adipose cells (28% smaller, P < 0.01). Besides, Epi was able to decrease insulin, leptin, and Homeostasis Model Assessment -Insulin Resistance (HOMA-IR) (P < 0.05), as well as triglycerides, when the experimental group was compared to the untreated male offspring of obese rats (P < 0.01).

Conclusions:

Epi administration can reverse the negative effects that maternal obesity has on the male offspring. This could be because Epi reduces the amount of visceral fat and improves metabolic profile.

Keywords

(-)-epicatechinmale offspringmaternal obesityrats
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 11 , Issue 1 , February 2020 , pp. 37 - 43
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2019 

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