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Effects of maternal hypothyroidism in the gastrointestinal system of male young offspring from Wistar rats

Published online by Cambridge University Press:  29 April 2020

Lívia Prometti de Rezende ,
Jéssica Fortunato Silva ,
Victor Augusto Alves da Costa ,
Luiz Borges Bispo da Silva  and
Ana Paula Coelho Balbi Open the ORCID record for Ana Paula Coelho Balbi [Opens in a new window]
Lívia Prometti de Rezende
Affiliation:
Program in Applied Structural and Cellular Biology, Federal University of Uberlândia, Uberlândia, Brazil
Jéssica Fortunato Silva
Affiliation:
Program in Applied Structural and Cellular Biology, Federal University of Uberlândia, Uberlândia, Brazil
Victor Augusto Alves da Costa
Affiliation:
Program in Applied Structural and Cellular Biology, Federal University of Uberlândia, Uberlândia, Brazil
Luiz Borges Bispo da Silva
Affiliation:
Department of Pharmacology, Federal University of Uberlândia, Uberlândia, Brazil
Ana Paula Coelho Balbi*
Affiliation:
Department of Physiology, Federal University of Uberlândia, Uberlândia, Brazil
*
Address for correspondence: Ana Paula Coelho Balbi, Department of Physiology, Federal University of Uberlândia, Avenida Pará, 1720, Campus Umuarama, Bloco 2A, Uberlândia, Minas Gerais, Brazil. Emails: [email protected]; [email protected]
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Abstract

Alterations in the maternal environment may impact on the fetal development. The objective of this study was to investigate the gastrointestinal consequences of maternal hypothyroidism for the male offspring from Wistar rats. The pregnant rats were divided into three groups: control (C – received water), experimental 1 [E1 – received methimazole (MMI) solution] during gestation and lactation, and experimental 2 (E2 – received MMI solution) during gestation. Maternal parameters evaluated: free T3 and T4, bodyweight variation, and water/food intake. Offspring parameters evaluated: litter size, number of male/female, free T3 and T4, stomach area, gastric ulcer susceptibility, small intestine length and weight, small intestine and distal colon motility, the stomach and intestinal weight–body weight ratio (SW/BW–IW/BW), and the accumulation of intestinal fluid. Maternal T3 and T4 from E1 were decreased when compared to the other groups. There were no differences for maternal water/food intake and weight gain, litter size, and number of males and females. Regarding to offspring, free T3, SW/BW, IW/BW, and intestinal fluid accumulation were not different between the groups, but T4 was decreased in E1. However, 30-day-old pups from E1 and E2 were smaller with lower stomach and small intestine. Even more, E1 presented a lower ulcer index when compared to the C, while E2 had a higher distal colon transit. It can be concluded that maternal hypothyroidism impaired the total body development, as well as gastric and intestinal development, besides interfering with the susceptibility to the ulcer and intestinal transit of male offspring from Wistar rats.

Keywords

Maternal hypothyroidismgastrointestinal tractoffspringWistar rats
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 12 , Issue 2 , April 2021 , pp. 286 - 292
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Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2020

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