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Decoding the ‘embryonic’ nature of embryonal rhabdomyosarcoma

Published online by Cambridge University Press:  05 March 2015

R. Lav Open the ORCID record for R. Lav [Opens in a new window] ,
R. Heera  and
L. M. Cherian
R. Lav*
Affiliation:
Department of Oral Pathology and Microbiology, Government Dental College, Gandhinagar, Kottayam, India
R. Heera
Affiliation:
Department of Oral Pathology and Microbiology, Government Dental College, Gandhinagar, Kottayam, India
L. M. Cherian
Affiliation:
Department of Oral Pathology and Microbiology, Government Dental College, Gandhinagar, Kottayam, India
*
*Address for correspondence: R. Lav, Department of Oral Pathology and Microbiology, Government Dental College, Medical College P.O., Gandhinagar, Kottayam 686008, India (Email [email protected])
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Abstract

Embryonal rhabdomyosarcoma is one of the major defined histologic variants of rhabdomyosarcoma that is mainly reported in children. The histologic appearance of this neoplastic entity recapitulates normal myogenesis. The tumor cells variably exhibit the different cellular phases of myogenesis ranging from undifferentiated mesenchymal cells to elongated myoblasts, multinucleated myotubes and differentiated muscle fibers. The carefully orchestrated embryonic signaling pathways that are involved in myogenesis, conceivably also result in the genesis of rhabdomyosarcoma; albeit as a corollary to an imbalance. We have attempted to review the pathogenesis of embryonal rhabdomyosarcoma in an endeavor to understand better, how closely it is linked to normal myogenesis in terms of its molecular dynamics and histologic presentation.

Keywords

embryonalmyogenesispathogenesisrhabdomyosarcoma
Type
Review
Information
Journal of Developmental Origins of Health and Disease , Volume 6 , Issue 3 , June 2015 , pp. 163 - 168
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Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2015 

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