Hostname: page-component-586b7cd67f-dsjbd Total loading time: 0 Render date: 2024-11-26T07:05:58.539Z Has data issue: false hasContentIssue false
  • English
  • Français

The association between gestational age and otitis media during childhood: a population-based cohort analysis

Published online by Cambridge University Press:  18 September 2018

Majdi Imterat Open the ORCID record for Majdi Imterat [Opens in a new window] ,
Tamar Wainstock ,
Jacob Moran-Gilad ,
Eyal Sheiner  and
Asnat Walfisch
Majdi Imterat*
Affiliation:
Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel
Tamar Wainstock
Affiliation:
Department of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
Jacob Moran-Gilad
Affiliation:
Department of Health Systems Management, School of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
Eyal Sheiner
Affiliation:
Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel
Asnat Walfisch
Affiliation:
Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel
*
Address for correspondence: M. Imterat, Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer Sheva 84101, Israel. E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Otitis media (OM) carries a tremendous global health burden and potentially severe long-term consequences. The objective of this study was to determine the impact of birth at different gestational ages on the incidence of childhood OM.

A population-based cohort analysis was conducted. All singleton deliveries occurring between 1991 and 2014 at a regional tertiary medical center were included. Gestational age on delivery was divided into six subgroups: early (<34 weeks gestation; 0 out of 7) and late (34 weeks gestation; 0 out of 7 to 36 weeks gestation; 6 out of 7) preterm, and early (37 weeks gestation; 0 out of 7 to 38 weeks gestation; 6 out of 7), full (39 weeks gestation; 0 out of 7 to 40 weeks gestation; 6 out of 7), late (41 weeks gestation; 0 out of 7 to 41 weeks gestation; 6 out of 7) and post (⩾42 weeks 0 out of 7) term deliveries. Rates of OM-related hospitalizations up to 18 years of age were assessed. Weibull parametric hazards model was used to study the association between gestational age at birth and the risk for OM-related hospitalizations while controlling for potential confounders.

During the study period, 238,622 deliveries met the inclusion criteria. OM-related hospitalizations of the offspring (n=4724) were significantly more common in the preterm (early 3.6%, late 2.4%) and early-term born children (2.2%) and decreased gradually across the full (1.9%), late (1.7%) and post (1.6%) term groups (χ2-test for trends P<0.001). In the Weibull regression model, early preterm, as well as early-term deliveries exhibited an independent association with pediatric OM (adjusted hazard ratios: 1.67 and 1.09, respectively, P<0.02).

Deliveries occurring at preterm and early term are associated with higher rates of pediatric OM-related hospitalizations, which decrease gradually as gestational age advances.

Keywords

follow-upinfectionoffspringpediatric morbiditypregnancy
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 10 , Issue 2 , April 2019 , pp. 214 - 220
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2018. 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Todberg, T, Koch A, Andersson M, et al. Incidence of otitis media in a contemporary Danish National Birth Cohort. PLoS One. 2014; 9, e111732.Google Scholar
2. Coker TR, Chan LS, Newberry SJ, et al. Diagnosis, microbial epidemiology, and antibiotic treatment of acute otitis media in children: a systematic review. JAMA. 2010; 304, 2161–2169.Google Scholar
3. American Academy of Pediatrics Subcommittee on Management of Acute Otitis Media. Diagnosis and management of acute otitis media. Pediatrics. 2004; 113, 1451.Google Scholar
4. Faden, H, Duffy, L, Boeve, M. Otitis media: back to basics. Pediatr Infect Dis J. 1998; 17, 1105–1113.Google Scholar
5. Lieberthal AS, Carroll AE, Chonmaitree T, et al. The diagnosis and management of acute otitis media. Pediatrics. 2013; 131, e964–e999.Google Scholar
6. Fiellau-Nikolajsen, M, Lous, J. Prospective tympanometry in 3-year-old children: a study of the spontaneous course of tympanometry types in a nonselected population. Arch Otolaryngol. 1979; 105, 461–466.Google Scholar
7. Teele DW, Klein JO, Chase C, et al. Otitis media in infancy and intellectual ability, school achievement, speech, and language at age 7 years. J Infect Dis. 1990; 162, 685–694.Google Scholar
8. Uhari, M, Mäntysaari, K, Niemelä, M. Meta-analytic review of the risk factors for acute otitis media. Clin Infect Dis. 1996; 22, 1079–1083.Google Scholar
9. Kero, P, Piekkala, P. Factors affecting the occurrence of acute otitis media during the first year of life. Acta Paediatrica. 1987; 76, 618–623.Google Scholar
10. Bland, RD. Otitis media in the first six weeks of life: diagnosis, bacteriology, and management. Pediatrics. 1972; 49, 187–197.Google Scholar
11. Berman, SA, Balkany, TJ, Simmons, MA. Otitis media in the neonatal intensive care unit. Pediatrics. 1978; 62, 198–201.Google Scholar
12. Bowatte G, Tham R, Allen KJ, et al. Breastfeeding and childhood acute otitis media: a systematic review and meta‐analysis. Acta Paediatrica. 2015; 104, 85–95.Google Scholar
13. Merewood A, Brooks D, Bauchner H, et al. Maternal birthplace and breastfeeding initiation among term and preterm infants: a statewide assessment for Massachusetts. Pediatrics. 2006; 118, e1048–e1054.Google Scholar
14. Newman DE, Paamoni-Keren O, Press F, et al. Neonatal outcome in preterm deliveries between 23 and 27 weeks’ gestation with and without preterm premature rupture of membranes. Arch Gynecol Obstet. 2009; 280, 7–11.Google Scholar
15. Jacobson, L. Visual dysfunction and ocular signs associated with periventricular leukomalacia in children born preterm. Acta Ophthalmol Scand. 1999; 77, 365–366.Google Scholar
16. Bhutta AT, Cleves MA, Casey PH, et al. Cognitive and behavioral outcomes of school-aged children who were born preterm: a meta-analysis. JAMA. 2002; 288, 728–737.Google Scholar
17. Lott, JW. State of the science: neonatal bacterial infection in the early 21st century. J Perinat Neonatal Nurs. 2006; 20, 62–70.Google Scholar
18. World Health Organization. ICD-10: International Statistical Classification of Diseases and Related Health, Tenth Revision [Internet] (vol. 2), 2nd edn, 2004. WHO: Geneva. Retrieved 12 August 2013 from: http://www.who.int/classifications/icd/ICD-10_2nd_ed_volume2.pdf Google Scholar
19. Tita AT, Landon MB, Spong CY, et al. Timing of elective repeat cesarean delivery at term and neonatal outcomes. N Engl J Med. 2009; 360, 111–120.Google Scholar
20. Machado Jr, Luis C, Passini Jr, et al. Neonatal outcomes of late preterm and early term birth. Eur J Obstet Gynecol Reprod Biol. 2014; 179, 204–208.Google Scholar
21. Walfisch A, Beharier O, Wainstock T, et al. Early‐term deliveries as an independent risk factor for long‐term respiratory morbidity of the offspring. Pediatr Pulmonol. 2017; 52, 198–204.Google Scholar
22. C Clark SL, Miller DD, Belfort MA, et al. Neonatal and maternal outcomes associated with elective term delivery. Am J Obstet Gynecol. 2009; 200, 156.e1–e4.Google Scholar
23. Dietz PM, Rizzo JH, England LJ, et al. Early term delivery and health care utilization in the first year of life. J Pediatr. 2012; 161, 234–239.Google Scholar
24. Walfisch A, Wainstock T, Beharier O, et al. Early term deliveries and the risk of pediatric obstructive sleep apnoea in the offspring. Paediatr Perinat Epidemiol. 2017; 31, 149–156.Google Scholar
25. Paz Levy D, Sheiner E, Wainstock T, et al. Evidence that children born at early term (37-38 6/7 weeks) are at increased risk for diabetes and obesity-related disorders. Am J Obstet Gynecol. 2017; 217, 588e1–588e11.Google Scholar
26. Spong, CY. Defining “term” pregnancy: recommendations from the Defining “Term” Pregnancy Workgroup. JAMA. 2013; 309, 2445–2446.Google Scholar
27. Statistics TCBo [Internet]. Israel in Figures 2013 [updated 25 May 2015]. Retrieved from: http://www.cbs.gov.il/www/publications/isr_in_n15e.pdf Google Scholar
28. Gouyon JB, Vintejoux A, Sagot P, et al. Neonatal outcome associated with singleton birth at 34–41 weeks of gestation. Int J Epidemiol. 2010; 39, 769–776.Google Scholar
29. American College of Obstetricians and Gynecologists. ACOG Practice Bulletin No. 97: Fetal lung maturity. Obstet Gynecol. 2008; 112, 717.Google Scholar
30. Chonmaitree T, Revai K, Grady JJ, et al. Viral upper respiratory tract infection and otitis media complication in young children. Clin Infect Dis. 2008; 46, 815–823.Google Scholar
31. Chonmaitree T, Trujillo R, Jennings K, et al. Acute otitis media and other complications of viral respiratory infection. Pediatrics. 2016; e20153555.Google Scholar
32. US Department of Health and Human Services. The health consequences of smoking—50 years of progress: a report of the surgeon general. Atlanta, GA: US Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health 2014; 17.Google Scholar
33. National Center for Chronic Disease Prevention and Health Promotion [Internet]. Centers for Disease Control and Prevention, Breastfeeding Report Card. 2013. Retrieved from: www.cdc.gov/breastfeeding/pdf/2013BreastfeedingReportCard.pdf.Google Scholar
34. Ministry of Health [Internet], State of Israel 2018. Retrieved from: https://www.health.gov.il/English/Topics/Pregnancy/Vaccination_of_infants/Pages/default.aspx Google Scholar
35. Organization for Economic Co-operation and Development, Child vaccination rates (indicator) [updated 11 November 2017]. Retrieved from: https://doi.org/10.1787/b23c7d13-en Google Scholar
36. Gerten KA, Coonrod DV, Bay RC, et al. Cesarean delivery and respiratory distress syndrome: does labor make a difference? Am J Obstet Gynecol. 2005; 193, 1061–1064.Google Scholar
37. Black M, Bhattacharya S, Philip S, et al. Planned cesarean delivery at term and adverse outcomes in childhood health. JAMA. 2015; 314, 2271–2279.Google Scholar
Supplementary material: File

Imterat et al. supplementary material

Imterat et al. supplementary material 1

Download Imterat et al. supplementary material(File)
File 13.4 KB