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25-hydroxyvitamin D status of pregnant women is associated with the use of antenatal vitamin supplements and ambient ultraviolet radiation

Published online by Cambridge University Press:  21 April 2016

A. P. Jones ,
K. Rueter ,
A. Siafarikas ,
E.-M. Lim ,
S. L. Prescott  and
D. J. Palmer
A. P. Jones
Affiliation:
School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia Telethon Kids Institute, University of Western Australia, Perth, Western Australia
K. Rueter
Affiliation:
School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia Immunology Department, Princess Margaret Hospital for Children, Perth, Western Australia
A. Siafarikas
Affiliation:
School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia Telethon Kids Institute, University of Western Australia, Perth, Western Australia Department of Endocrinology and Diabetes, Princess Margaret Hospital for Children, Perth, Western Australia
E.-M. Lim
Affiliation:
Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Western Australia Department of Clinical Biochemistry, PathWest Laboratory Medicine, Queen Elizabeth II Medical Centre, Perth, Western Australia
S. L. Prescott
Affiliation:
School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia Telethon Kids Institute, University of Western Australia, Perth, Western Australia Immunology Department, Princess Margaret Hospital for Children, Perth, Western Australia
D. J. Palmer*
Affiliation:
School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia Telethon Kids Institute, University of Western Australia, Perth, Western Australia
*
*Address for correspondence: Dr D. Palmer, School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia PO Box D184, Princess Margaret Hospital, Perth WA 6001, Australia. (Email [email protected])
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Abstract

Previous research suggests prevalent vitamin D deficiency in pregnant women residing in South Australia and the Eastern Seaboard, however recent data from Perth, Western Australia (WA) is lacking. This cross-sectional study of n=209 pregnant women (36–40 weeks of gestation, 84% white Caucasian) reports on the vitamin D (25[OH]D) status of a contemporary population of pregnant women in Perth, WA, with a focus on the relative contributions of supplemental vitamin D and ambient ultraviolet (UV) radiation to 25(OH)D levels. Mean (SD) season-adjusted 25(OH)D levels were 77.7 (24.6) nmol/l. The prevalence of vitamin D deficiency (25[OH]D<50 nmol/l) was 13.9%. Ambient UV radiation levels in the 90 days preceding blood draw were significantly correlated with serum 25(OH)D levels (unstandardized coefficient 2.82; 95% CI 1.77, 3.86, P<0.001). Vitamin D supplementation expressed as dose per kg of body weight was also positively correlated with serum 25(OH)D levels (unstandardized coefficient 0.744; 95% CI 0.395, 1.092, P<0.001). In conclusion, this study finds that vitamin D deficiency in a predominantly white Caucasian cohort of pregnant women is less prevalent than has been reported in other studies, providing useful information relating to supplementation and screening in this, and similar, populations.

Keywords

gestational diabetes mellituspregnancysupplementationultraviolet radiationUV indexvitamin D25(OH)D
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 7 , Issue 4 , August 2016 , pp. 350 - 356
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Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2016 

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References

1. Bodnar, LM, Simhan, HN, Catov, JM, et al. Maternal vitamin D status and the risk of mild and severe preeclampsia. Epidemiology. 2014; 25, 207–214.Google Scholar
2. Yap, C, Cheung, NW, Gunton, JE, et al. Vitamin D supplementation and the effects on glucose metabolism during pregnancy: a randomized controlled trial. Diabetes Care. 2014; 37, 1837–1844.Google Scholar
3. Arnold, DL, Enquobahrie, DA, Qiu, C, et al. Early pregnancy maternal vitamin D concentrations and risk of gestational diabetes mellitus. Paediatr Perinat Epidemiol. 2015; 29, 200–210.CrossRefGoogle ScholarPubMed
4. Al Kabani, M, Elshafie, O, Rawahi, M, et al. Vitamin D status in pregnant omanis: a disturbingly high proportion of patients with low vitamin D stores. Sultan Qaboos Univ Med J. 2011; 11, 52–55.Google Scholar
5. Halicioglu, O, Aksit, S, Koc, F, et al. Vitamin D deficiency in pregnant women and their neonates in spring time in western Turkey. Paediatr Perinat Epidemiol. 2012; 26, 53–60.Google Scholar
6. Hamilton, SA, McNeil, R, Hollis, BW, et al. Profound vitamin D deficiency in a diverse group of women during pregnancy living in a sun-rich environment at latitude 32°N. Int J Endocrinol. 2010; 2010, 917428.Google Scholar
7. Bowyer, L, Catling-Paull, C, Diamond, T, et al. Vitamin D, PTH and calcium levels in pregnant women and their neonates. Clin Endocrinol (Oxf). 2009; 70, 372–377.Google Scholar
8. Teale, GR, Cunningham, CE. Vitamin D deficiency is common among pregnant women in rural Victoria. Aust N Z J Obstet Gynaecol. 2010; 50, 259–261.Google Scholar
9. Thomas, SDC, Fudge, AN, Whiting, M, Coates, PS. The correlation between third-trimester maternal and newborn-serum 25-hydroxy-vitamin D in a selected South Australian group of newborn samples. BMJ Open. 2011; 1, e000236.Google Scholar
10. Hart, PH, Lucas, RM, Walsh, JP, et al. Vitamin D in fetal development: findings from a birth cohort study. Pediatrics. 2015; 135, e167–e173.Google Scholar
11. ComLaw. Australia New Zealand Food Standards Code – Standard 2.4.2-Edible Oil Spreads. 2011.Google Scholar
12. Kimlin, MG, Lucas, RM, Harrison, SL, et al. The contributions of solar ultraviolet radiation exposure and other determinants to serum 25-hydroxyvitamin D concentrations in Australian adults: the AusD Study. Am J Epidemiol. 2014; 179, 864–874.Google Scholar
13. Diamond, T, Eisman, JA, Mason, R, et al. Vitamin D and adult bone health in Australia and New Zealand: a position statement. Med J Aust. 2005; 182, 281–285.Google Scholar
14. National Health and Medical Research Council. Nutrient reference values for Australia and New Zealand. Canberra: Department of Health and Ageing; 2005.Google Scholar
15. Bilinski, K, Talbot, P. Vitamin D supplementation in Australia: implications for the development of supplementation guidelines. J Nutr Metab. 2014; 2014, 374208.Google Scholar
16. Holick, MF, Binkley, NC, Bischoff-Ferrari, HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011; 96, 1911–1930.Google Scholar
17. Fitzpatrick, TB. The validity and practicality of sun reactive skin types I through VI. Arch Dermatol. 1988; 124, 869–871.Google Scholar
18. Jones, AP, Palmer, D, Zhang, G, Prescott, SL. Cord blood 25-hydroxyvitamin D3 and allergic disease during infancy. Pediatrics. 2012; 130, e1128–e1135.CrossRefGoogle ScholarPubMed
19. Bureau of Meteorology. About the UV index, 2016. Retrieved 19 January 2016 from www.bom.gov.au/uv/about_uv_index.shtml.Google Scholar
20. Australian Radiation Protection and Nuclear Safety Agency. Monthly UV Index Summaries for Perth, 2016. Retrieved 20 January 2016 from http://www.arpansa.gov.au.Google Scholar
21. Chan, J, Jaceldo-Siegl, K, Fraser, GE. Determinants of serum 25 hydroxyvitamin D levels in a nationwide cohort of blacks and non-Hispanic whites. Cancer Causes Control. 2010; 21, 501–511.Google Scholar
22. The Royal Australian and New Zealand College of Obstetricians and Gynaecologists. College Communiqués: Diagnosis of Gestational Diabetes Mellitus (GDM) in Australia 2015.Google Scholar
23. Jenab, M, Bueno-de-Mesquita, HB, Ferrari, P, et al. Association between pre-diagnostic circulating vitamin D concentration and risk of colorectal cancer in European populations: a nested case-control study. BMJ. 2010; 340, b5500.Google Scholar
24. Bogh, MK, Schmedes, AV, Philipsen, PA, Thieden, E, Wulf, HC. Interdependence between body surface area and ultraviolet B dose in vitamin D production: a randomized controlled trial. Br J Dermatol. 2011; 164, 163–169.Google Scholar
25. Farrell, CJ, Martin, S, McWhinney, B, et al. State-of-the-art vitamin D assays: a comparison of automated immunoassays with liquid chromatography-tandem mass spectrometry methods. Clin Chem. 2012; 58, 531–542.Google Scholar