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25-hydroxyvitamin D status of pregnant women is associated with the use of antenatal vitamin supplements and ambient ultraviolet radiation

Published online by Cambridge University Press:  21 April 2016

A. P. Jones ,
K. Rueter ,
A. Siafarikas ,
E.-M. Lim ,
S. L. Prescott  and
D. J. Palmer
A. P. Jones
Affiliation:
School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia Telethon Kids Institute, University of Western Australia, Perth, Western Australia
K. Rueter
Affiliation:
School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia Immunology Department, Princess Margaret Hospital for Children, Perth, Western Australia
A. Siafarikas
Affiliation:
School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia Telethon Kids Institute, University of Western Australia, Perth, Western Australia Department of Endocrinology and Diabetes, Princess Margaret Hospital for Children, Perth, Western Australia
E.-M. Lim
Affiliation:
Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Western Australia Department of Clinical Biochemistry, PathWest Laboratory Medicine, Queen Elizabeth II Medical Centre, Perth, Western Australia
S. L. Prescott
Affiliation:
School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia Telethon Kids Institute, University of Western Australia, Perth, Western Australia Immunology Department, Princess Margaret Hospital for Children, Perth, Western Australia
D. J. Palmer*
Affiliation:
School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia Telethon Kids Institute, University of Western Australia, Perth, Western Australia
*
*Address for correspondence: Dr D. Palmer, School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia PO Box D184, Princess Margaret Hospital, Perth WA 6001, Australia. (Email [email protected])
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Abstract

Previous research suggests prevalent vitamin D deficiency in pregnant women residing in South Australia and the Eastern Seaboard, however recent data from Perth, Western Australia (WA) is lacking. This cross-sectional study of n=209 pregnant women (36–40 weeks of gestation, 84% white Caucasian) reports on the vitamin D (25[OH]D) status of a contemporary population of pregnant women in Perth, WA, with a focus on the relative contributions of supplemental vitamin D and ambient ultraviolet (UV) radiation to 25(OH)D levels. Mean (SD) season-adjusted 25(OH)D levels were 77.7 (24.6) nmol/l. The prevalence of vitamin D deficiency (25[OH]D<50 nmol/l) was 13.9%. Ambient UV radiation levels in the 90 days preceding blood draw were significantly correlated with serum 25(OH)D levels (unstandardized coefficient 2.82; 95% CI 1.77, 3.86, P<0.001). Vitamin D supplementation expressed as dose per kg of body weight was also positively correlated with serum 25(OH)D levels (unstandardized coefficient 0.744; 95% CI 0.395, 1.092, P<0.001). In conclusion, this study finds that vitamin D deficiency in a predominantly white Caucasian cohort of pregnant women is less prevalent than has been reported in other studies, providing useful information relating to supplementation and screening in this, and similar, populations.

Keywords

gestational diabetes mellituspregnancysupplementationultraviolet radiationUV indexvitamin D25(OH)D
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 7 , Issue 4 , August 2016 , pp. 350 - 356
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Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2016 

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