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Oxygen concentration in milk of healthy and mastitic cows and implications of low oxygen tension for the killing of Staphylococcus aureus by bovine neutrophils

Published online by Cambridge University Press:  01 June 2009

Susan J. Mayer ,
Avril E. Waterman ,
Peter M. Keen ,
Neil Craven  and
F. John Bourne
Susan J. Mayer
Affiliation:
Departments of Veterinary Medicine, Langford, Bristol BS18 7DU, UK
Avril E. Waterman
Affiliation:
Departments of Veterinary Surgery, Langford, Bristol BS18 7DU, UK
Peter M. Keen
Affiliation:
Departments of Pharmacology, University of Bristol Veterinary School, Langford, Bristol BS18 7DU, UK
Neil Craven
Affiliation:
Monsanto plc, Basingstoke, Hants, UK
F. John Bourne
Affiliation:
Departments of Veterinary Medicine, Langford, Bristol BS18 7DU, UK
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Summary

The partial pressure of O2 in milk from normal cows and from cows with mastitis was measured and the concentrations of O2 calculated. Oxygen levels of milk from normal cows were similar to those in venous plasma, but inflammation of the mammary gland led to a dramatic drop in O2 concentration to < 10% of control values. Intracellular survival of Staphylococcus aureus strain M60 in bovine neutrophils was greater under anaerobic than aerobic conditions. The implications of low O2 concentrations in milk from infected mammary glands for the bactericidal activity of bovine neutrophils is discussed.

Type
Original articles
Information
Journal of Dairy Research , Volume 55 , Issue 4 , November 1988 , pp. 513 - 519
Copyright
Copyright © Proprietors of Journal of Dairy Research 1988

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