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Nerve Growth Factor mediates its pro-invasive effect in parallel with the release of a soluble E-cadherin fragment from breast cancer MCF-7/AZ cells

Published online by Cambridge University Press:  22 July 2005

Laurent Dollé ,
Maria-José Oliveira ,
Erik Bruyneel ,
Hubert Hondermarck  and
Marc Bracke
Laurent Dollé
Affiliation:
Laboratory of Experimental Cancerology, Department of Radiotherapy and Nuclear Medicine, Ghent University Hospital, De Pintelaan 185, B-9000 Ghent, Belgium
Maria-José Oliveira
Affiliation:
Instituto de Pathologia e Immunologia Molecular da Universidade do Porto, Porto, Portugal
Erik Bruyneel
Affiliation:
Laboratory of Experimental Cancerology, Department of Radiotherapy and Nuclear Medicine, Ghent University Hospital, De Pintelaan 185, B-9000 Ghent, Belgium
Hubert Hondermarck
Affiliation:
UPRES-EA 1033, INSERM-ESPRI “Growth Factor Signalling In Breast Cancer. Functional Proteomics”, University of Sciences and Technologies Lille, France
Marc Bracke
Affiliation:
Laboratory of Experimental Cancerology, Department of Radiotherapy and Nuclear Medicine, Ghent University Hospital, De Pintelaan 185, B-9000 Ghent, Belgium
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Abstract

To define better the function of Nerve Growth Factor (NGF) in breast cancer progression, we investigated whether this polypeptide was able to induce breast cancer cell invasion. NGF inhibited aggregation of tumour cells through modulation of the E-cadherin/catenin complex function. In addition, NGF induced the breast cancer cells to invade into Matrigel. We focused our attention on how NGF prevents aggregation, in order to discover the signalling pathway that leads tumour cells to acquire the invasive phenotype. Moreover, studies on the identification of signalling pathways that are responsive for NGF-induced invasion will be basically described.

Keywords

E-cadherinsoluble fragmentinvasionNerve Growth Factorbreast cancer cells
Type
Research Article
Information
Journal of Dairy Research , Volume 72 , Issue S1 , August 2005 , pp. 20 - 26
Copyright
Proprietors of Journal of Dairy Research 2005

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