Hostname: page-component-cd9895bd7-lnqnp Total loading time: 0 Render date: 2025-01-03T13:44:32.727Z Has data issue: false hasContentIssue false
  • English
  • Français

Interspecies study on the effect of perphenazine on milk yield and composition

Published online by Cambridge University Press:  01 June 2009

J. Shani (Mishkinsky) ,
A. T. Cowie  and
W. H. Broster
J. Shani (Mishkinsky)
Affiliation:
National Institute for Research in Dairying, Shinfield, Reading, RG2 9AT
A. T. Cowie
Affiliation:
National Institute for Research in Dairying, Shinfield, Reading, RG2 9AT
W. H. Broster
Affiliation:
National Institute for Research in Dairying, Shinfield, Reading, RG2 9AT
Get access Rights & Permissions [Opens in a new window]

Summary

The effects on lactation of perphenazine, a tranquillizer which increases the level of prolactin in the blood, have been studied in cows, goats, guinea-pigs and rabbits. The drug caused a significant depression of milk yield in cows, goats and rabbits, but was without effect on the milk yield of guinea-pigs. It seems probable that the inhibitory effects on lactation were due to the actions of the drug on appetite and behaviour. It is concluded that perphenazine, because of its other actions, is not a suitable agent for studying the physiological effects of increased levels of endogenous prolactin.

Type
Research Article
Information
Journal of Dairy Research , Volume 42 , Issue 1 , February 1975 , pp. 1 - 9
Copyright
Copyright © Proprietors of Journal of Dairy Research 1975

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Besser, G. M., Parke, L., Edwards, C. R. W., Forsyth, I. A. & McNeilly, A. S. (1972). British Medical Journal iii, 669.Google Scholar
British Standards Institution (1963). B.S. No. 1741.Google Scholar
Bush, L. J., Yang, M. G. & Odell, G. V. (1960). Journal of Dairy Science 43, 1118.Google Scholar
Buttle, H. L., Forsyth, I. A. & Knaggs, G. S. (1972). Journal of Endocrinology 53, 483.Google Scholar
Convey, E. M. (1973). Journal of Animal Science 37, 745.Google Scholar
Convey, E. M., Tucker, H. A., Smith, V. G. & Zolman, J. (1973). Endocrinology 92, 471.Google Scholar
Cowie, A. T. (1969 a). In Lactogenesvs, pp. 157–169. (Eds Reynolds, M. and Folley, S. J..) Philadelphia Pa: University of Pennsylvania Press.Google Scholar
Cowie, A. T. (1969 b). Journal of Endocrinology 44, 437.Google Scholar
Cowie, A. T., Hartmann, P. E. & Turvey, A. (1969). Journal of Endocrinology 43, 651.Google Scholar
Cowie, A. T. & Tindal, J. S. (1971). The physiology of lactation. London: Arnold.Google Scholar
Del Pozo, E., Brun del Re, R., Varga, L. & Friesen, H. (1972). Journal of Clinical Endocrinology and Metabolism 35, 768.Google Scholar
Fitko, R. & Kulisiewicz, B. (1971). Polskie Archiwum Weterynaryjne 14, 537.Google Scholar
Hart, I. C. (1973). Journal of Endocrinology 57, 179.Google Scholar
Jordan, D. C. & Ward, G. M. (1958). Journal of Dairy Science 41, 1485.Google Scholar
Karg, H., Schams, D. & Reinhardt, V. (1972). Experientia 28, 574.Google Scholar
Kelly, P. A., Bedirian, K. N., Baker, R. D. & Friesen, H. G. (1973). Endocrinology 92, 1289.Google Scholar
Lassiter, C. A., Huffman, C. F. & Duncan, C. W. (1958). Journal of Animal Science 17, 1222.Google Scholar
McNeilly, J. R. & Lamming, G. E. (1971). Journal of Endocrinology 50, 359.Google Scholar
Morag, M., Shani (Mishkinsky), J., Sulman, F. G. & Yagil, R. (1971). Journal of Endocrinology 49, 351.Google Scholar
Nagasawa, H. & Naito, M. (1962). Japanese Journal of Zootechnical Sciences 33, 165.Google Scholar
Nagasawa, H. & Naito, M. (1963). Japanese Journal of Zootechnical Sciences 34, 174.Google Scholar
Rajeswaran, P. & Kirk, P. L. (1971). Bulletin on Narcotics 8, 15.Google Scholar
Schams, D., Reinhardt, V. & Karg, H. (1972). Experientia 28, 697.Google Scholar
Schams, D., Reinhardt, V. & Karg, H. (1973). Milchwissenschaft 28, 409.Google Scholar
Sulman, F. G. (1970). Hypothalamic control of lactation. Berlin: Springer-Velag.Google Scholar
Weller, C. P., Shani (Mishkinsky), J., Givant, Y. & Sulman, F. G. (1972). Archives Internationales de Pharmacodynamie et de Thérapie 200, 405.Google Scholar