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Effect of postpartum propylene glycol allocation to over-conditioned Holstein cows on concentrations of milk metabolites

Published online by Cambridge University Press:  01 April 2016

Vibeke Bjerre-Harpøth ,
Adam C. Storm ,
Mogens Vestergaard ,
Mogens Larsen  and
Torben Larsen
Vibeke Bjerre-Harpøth
Affiliation:
Department of Animal Science, Aarhus University, Foulum, DK-8830 Tjele, Denmark
Adam C. Storm
Affiliation:
Department of Animal Science, Aarhus University, Foulum, DK-8830 Tjele, Denmark
Mogens Vestergaard
Affiliation:
Department of Animal Science, Aarhus University, Foulum, DK-8830 Tjele, Denmark
Mogens Larsen
Affiliation:
Department of Animal Science, Aarhus University, Foulum, DK-8830 Tjele, Denmark
Torben Larsen*
Affiliation:
Department of Animal Science, Aarhus University, Foulum, DK-8830 Tjele, Denmark
*
*For correspondence; e-mail: [email protected]
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Abstract

The objective of the study was to investigate the effect of propylene glycol (PG) allocation on concentrations of milk metabolites with potential use as indicators of glucogenic status in high yielding postpartum dairy cows. At time of calving, nine ruminally cannulated Holstein cows were randomly assigned to ruminal dosing of 500 g/d tap water (CON, n = 4) or 500 g/d PG (PPG, n = 5). The PG was given with the morning feeding week 1–4 postpartum (treatment period) and cows were further followed during week 5–8 postpartum (follow-up period). All cows were fed the same postpartum diet. Milk samples were obtained at each milking (3 times/d) in the treatment period, and at morning milking during the follow-up period. Weekly blood samples were obtained from –4 to +8 weeks relative to calving and daily blood samples from –7 until +7 d relative to calving. The main effect of PG allocation was an increased glucogenic status, e.g. visualised by a prompt marked increase in blood fructosamine. During the treatment period, milk concentration of free glucose tended to be greater, whereas milk concentrations of isocitrate and BHBA were lower for PPG compared with CON. It is proposed that the ratio between free glucose and isocitrate in milk may be a potential biomarker for glucogenic status in the vulnerable early postpartum period. We will pursue this issue in the future.

Keywords

Propylene glycolmilk biomarkerglucogenic statusperiparturientdairy cows
Type
Research Article
Information
Journal of Dairy Research , Volume 83 , Issue 2 , May 2016 , pp. 156 - 164
Copyright
Copyright © Proprietors of Journal of Dairy Research 2016 

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References

Armbruster, DA 1987 Fructosamine: structure, analysis, and clinical usefulness. Clinical Chemistry 33 2153–2163Google Scholar
Bauman, DE & Griinari, JM 2003 Nutritional regulation of milk fat synthesis. Annual Review of Nutrition 23 203–227Google Scholar
Bauman, DE, Brown, RE & Davis, CL 1970 Pathways of fatty acid synthesis and reducing equivalent generation in mammary gland of rat, sow, and cow. Archives of Biochemistry and Biophysics 140 237–244Google Scholar
Bjerre-Harpøth, V, Larsen, M, Friggens, NC, Larsen, T, Weisbjerg, MR & Damgaard, BM 2014 Effect of dietary energy supply to dry Holstein cows with high or low body condition score at dry off on production and metabolism in early lactation. Livestock Science 168 60–75Google Scholar
Bjerre-Harpøth, V, Storm, AC, Eslamizad, M, Kuhla, B & Larsen, M 2015 Effect of propylene glycol on adipose tissue mobilization in postpartum over-conditioned Holstein cows. Journal of Dairy Science 98 8581–8596Google Scholar
Carrier, J, Stewart, S, Godden, S, Fetrow, J & Rapnicki, P 2004 Evaluation and use of three cowside tests for detection of subclinical ketosis in early postpartum cows. Journal of Dairy Science 87 3725–3735Google Scholar
Chaiyabutr, N, Faulkner, A & Peaker, M 1981 Changes in the concentrations of the minor constituents of goats milk during starvation and on refeeding of the lactating animal and their relationship to mammary-gland metabolism. British Journal of Nutrition 45 149–157Google Scholar
Chibisa, GE, Gozho, GN & Mutsvangwa, T 2009 Effect of propylene glycol supplementation on microbial protein production in transition dairy cows. Canadian Journal of Animal Science 89 419–423CrossRefGoogle Scholar
Cornelius, CE, Baker, NF, Kaneko, JJ & Douglas, JR 1962 Distribution and turnovver of iodine-131-tagged bovine albumine in normal and parasitized cattle. American Journal of Veterinary Research 23 837–842Google Scholar
Denis-Robichaud, J, Dubuc, J, Lefebvre, D & DesCôteaux, L 2014 Accuracy of milk ketone bodies from flow-injection analysis for the diagnosis of hyperketonemia in dairy cows. Journal of Dairy Science 97 3364–3370Google Scholar
DeVries, TJ, von Keyserlingk, MAG & Beauchemin, KA 2003 Short communication: diurnal feeding pattern of lactating dairy cows. Journal of Dairy Science 86 4079–4082Google Scholar
Enjalbert, F, Nicot, MC, Bayourthe, C & Moncoulon, R 2001 Ketone bodies in milk and blood of dairy cows: relationship between concentrations and utilization for detection of subclinical ketosis. Journal of Dairy Science 84 583–589CrossRefGoogle ScholarPubMed
Farrell, HM, Wickham, ED & Reeves, HC 1995 Effects of long-chain acyl-coenzyme as on the activity of the soluble form of nicotinamide adenine-dinucleotide phosphate-specific isocitrate dehydrogenase from lactating bovine mammary-gland. Archives of Biochemistry and Biophysics 321 199–208Google Scholar
Faulkner, A & Pollock, HT 1989 Changes in the concentration of metabolites in milk from cows fed on diets supplemented with soyabean oil or fatty acids. Journal of Dairy Research 56 179–183Google Scholar
Faulkner, A, Chaiyabutr, N, Peaker, M, Carrick, DT & Kuhn, NJ 1981 Metabolic significance of milk glucose. Journal of Dairy Research 48 51–56Google Scholar
Ferguson, JD, Galligan, DT & Thomsen, N 1994 Principal descriptors of body condition score in Holstein cows. Journal of Dairy Science 77 2695–2703Google Scholar
Garnsworthy, PC, Masson, LL, Lock, AL & Mottram, TT 2006 Variation of milk citrate with stage of lactation and de novo fatty acid synthesis in dairy cows. Journal of Dairy Science 89 1604–1612Google Scholar
Grummer, RR 1993 Etiology of lipid-related metabolic disorders in periparturient dairy-cows. Journal of Dairy Science 76 3882–3896CrossRefGoogle ScholarPubMed
Grummer, RR, Winkler, JC, Bertics, SJ & Studer, VA 1994 Effect of propylene glycol dosage during feed restriction on metabolites in blood of prepartum Holstein Heifers. Journal of Dairy Science 77 3618–3623Google Scholar
Harano, Y, Ohtsuki, M, Ida, M, Kojima, H, Harada, M, Okanishi, T, Kashiwagi, A, Ochi, Y, Uno, S & Shigeta, Y 1985 Direct automated assay method for serum or urine levels of ketone bodies. Clinica Chimica Acta 151 177–183Google Scholar
Ingvartsen, KL 2006 Feeding- and management-related diseases in the transition cow - Physiological adaptations around calving and strategies to reduce feeding-related diseases. Animal Feed Science and Technology 126 175–213Google Scholar
Kristensen, NB & Raun, BML 2007 Ruminal and intermediary metabolism of propylene glycol in lactating Holstein cows. Journal of Dairy Science 90 4707–4717Google Scholar
Larsen, MK, Weisbjerg, MR, Kristensen, CB & Mortensen, G 2012 Short communication: within-day variation in fatty acid composition of milk from cows in an automatic milking system. Journal of Dairy Science 95 5608–5611Google Scholar
Larsen, T 2012 Enzymatic-fluorometric quantification of cholesterol in bovine milk. Food Chemistry 135 1261–1267CrossRefGoogle ScholarPubMed
Larsen, T 2014 Fluorometric determination of free and total isocitrate in bovine milk. Journal of Dairy Science 97 7498–7504Google Scholar
Larsen, T 2015 Fluorometric determination of free glucose and glucose-6-phosphate in milk and other opaque matrices. Food Chemistry 166 283–286Google Scholar
Larsen, T & Moyes, KM 2010 Fluorometric determination of uric acid in bovine milk. Journal of Dairy Research 77 438–444Google Scholar
Larsen, T & Moyes, KM 2015 Are free glucose and glucose-6-phosphate in milk indicators of specific physiological states in the cow? Animal 9 86–93Google Scholar
Larsen, T & Nielsen, NI 2005 Fluorometric determination of beta-hydroxybutyrate in milk and blood plasma. Journal of Dairy Science 88 2004–2009Google Scholar
Larsen, T, Larsen, MK & Friggens, NC 2011 Enzymatic and fluorometric determination of triacylglycerols in cow milk and other opaque matrices. Food Chemistry 125 1110–1115Google Scholar
Larsen, T, Alstrup, L & Weisbjerg, MR 2016 Minor milk constituents are affected by protein concentration and forage digestibility in the feed ration. Journal of Dairy Research 83 12–19Google Scholar
Lien, TF, Chang, LB, Horng, YM & Wu, CP 2010 Effects of propylene glycol on milk production, serum metabolites and reproductive performance during the transition period of dairy cows. Asian-Australian Journal of Animal Science 23 372–378Google Scholar
Liu, H, Zhao, K & Liu, J 2013 Effect of glucose availability on expression of key genes involved in synthesis of milk fat, lactose, and glucose metabolism in bovine mammary epithelial cells. Plos One 8 e66092Google Scholar
Madsen, TG, Nielsen, L & Nielsen, MO 2005 Mammary nutrient uptake in response to dietary supplementation of rumen protected lysine and methionine in late and early lactating dairy goats. Small Ruminant Research 56 151–164Google Scholar
Nielsen, NI & Ingvartsen, KL 2004 Propylene glycol for dairy cows - A review of the metabolism of propylene glycol and its effects on physiological parameters, feed intake, milk production and risk of ketosis. Animal Feed Science and Technology 115 191–213Google Scholar
Nocek, JE & Braund, DG 1985 Effect of feeding frequency on diurnal dry matter and water consumption, liquid dilution rate, and milk yield in first lactation. Journal of Dairy Science 68 2238–2247Google Scholar
Palmquist, DL, Beulieu, AD & Barbano, DM 1993 Feed and animal factors influencing milk-fat composition. Journal of Dairy Science 86 1753–1771Google Scholar
Peaker, M & Faulkner, A 1983 Soluble milk constituents. Proceedings of the Nutrition Society 42 419–425Google Scholar
Rigout, S, Lemosquet, S, Bach, A, Blum, JW & Rulquin, H 2002 Duodenal infusion of glucose decreases milk fat production in grass silage-fed dairy cows. Journal of Dairy Science 85 2541–2550CrossRefGoogle ScholarPubMed
Ropstad, E 1987 Serum fructosamine level in dairy cows related to metabolic status in early lactation. Acta Agriculturae Scandinavica Section A – Animal Science 28 291–298Google ScholarPubMed
Stengärde, L, Tråvén, M, Emanuelson, U, Holtenius, K, Hultgren, J & Niskanen, R 2008 Metabolic profiles in five high-producing Swedish dairy herds with a history of abomasal displacement and ketosis. Acta Agriculturae Scandinavica Section A – Animal Science 50 31–41Google Scholar
Stentoft, C, Røjen, BA, Jensen, SK, Kristensen, NB, Vestergaard, M & Larsen, M 2015 Absorption and intermediary metabolism of purines and pyrimidines in lactating dairy cows. British Journal of Nutrition 113 560–573Google Scholar