Hostname: page-component-586b7cd67f-vdxz6 Total loading time: 0 Render date: 2024-11-23T16:11:30.007Z Has data issue: false hasContentIssue false
  • English
  • Français

Dietary phytanic acid-induced changes in tissue fatty acid profiles in mice

Published online by Cambridge University Press:  27 November 2020

Tomonori Nakanishi ,
Kazuhiro Kagamizono ,
Sayaka Yokoyama ,
Ryoji Suzuki ,
Hiroyuki Sakakibara ,
Kazuhiro Sugamoto ,
Laurie Erickson  and
Satoshi Kawahara
Tomonori Nakanishi*
Affiliation:
Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan
Kazuhiro Kagamizono
Affiliation:
Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan
Sayaka Yokoyama
Affiliation:
Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan
Ryoji Suzuki
Affiliation:
Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan
Hiroyuki Sakakibara
Affiliation:
Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan
Kazuhiro Sugamoto
Affiliation:
Department of Applied Chemistry, Faculty of Engineering, University of Miyazaki, Miyazaki, Japan
Laurie Erickson
Affiliation:
Department of Biology, Harold Washington City College of Chicago, Chicago, IL, USA Department of Health Sciences, Blitstein Institute of Hebrew Theological College, Chicago, IL, USA
Satoshi Kawahara
Affiliation:
Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan
*
Author for correspondence: Tomonori Nakanishi, Email: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

The aims of this research communication were to investigate the in vivo tissue accumulation of phytanic acid (PA) and any changes in the tissue fatty acid profiles in mice. Previous in vitro studies have demonstrated that PA is a milk component with the potential to cause both beneficial effects on lipid and glucose metabolism and detrimental effects on neuronal cells. However, there is limited information about its in vivo actions. In this study, mice were fed diets containing either 0.00 or 0.05% 3RS, 7R, 11R-PA, which is the isomer found in milk and the human body. After 4 weeks, adipose tissue, liver and brain were harvested and their fatty acid profiles were determined by gas chromatographic analysis. The results showed that PA and its metabolite pristanic acid accumulated in the adipose tissue of PA-fed mice, and that dietary PA decreased the hepatic compositions of several saturated fatty acids such as palmitic acid while increasing the compositions of polyunsaturated fatty acids including linoleic acid and docosahexaenoic acid. However, dietary PA neither accumulated nor had a high impact on the fatty acid profile in the brain. These results suggested that dietary PA could exert its biological activities in adipose tissue and liver, although the brain is relatively less affected by dietary PA. These data provide a basis for understanding the in vivo physiological actions of PA.

Keywords

Phytanic acidPristanic acidTissue fatty acid profileMouse
Type
Research Article
Information
Journal of Dairy Research , Volume 87 , Issue 4 , November 2020 , pp. 498 - 500
Copyright
Copyright © The Author(s), 2020. Published by Cambridge University Press on behalf of Hannah Dairy Research Foundation

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Brown, PJ, Mei, G, Gibberd, FB, Burston, D, Mayne, PD, McClinchy, JE and Sidey, M (1993) Diet and Refsum's disease. The determination of phytanic acid and phytol in certain foods and the application of this knowledge to the choice of suitable convenience foods for patients with Refsum's disease. Journal of Human Nutrition and Dietetics 6, 295–305.CrossRefGoogle Scholar
Che, BN, Kristensen, T, Nebel, C, Dalsgaard, TK, Hellgren, LI, Young, JF and Larsen, MK (2013) Content and distribution of phytanic acid diastereomers in organic milk as affected by feed composition. Journal of Agricultural Food Chemistry 61, 225–230.CrossRefGoogle ScholarPubMed
Corazzin, M, Romanzin, A, Sepulcri, A, Pinosa, M, Piasentier, E and Bovolenta, S (2019) Fatty acid profiles of cow's milk and cheese as affected by mountain pasture type and concentrate supplementation. Animals 9, 68.CrossRefGoogle ScholarPubMed
Hansen, RP (1966) Phytanic acid and other branched-chain fatty acid constituents of bovine rumen bacteria. Journal of Dairy Research 33, 333–342.CrossRefGoogle Scholar
Heim, M, Johnson, J, Boess, F, Bendik, I, Weber, P, Hunziker, W and Fluhmann, B (2002) Phytanic acid, a natural peroxisome proliferator-activated receptor (PPAR) agonist, regulates glucose metabolism in rat primary hepatocytes. FASEB Journal 16, 718–720.CrossRefGoogle ScholarPubMed
Hellgren, LI (2010) Phytanic acid – an overlooked bioactive fatty acid in dairy fat? Annals of the New York Academy of Sciences 1190, 42–49.CrossRefGoogle ScholarPubMed
Kawahara, S, Takenoyama, SI, Takuma, K, Muguruma, M and Yamauchi, K (2009) Effects of dietary supplementation with conjugated linoleic acid on fatty acid composition and lipid oxidation in chicken breast meat. Animal Science Journal 80, 468–474.CrossRefGoogle ScholarPubMed
Nakanishi, T, Anraku, M, Suzuki, R, Kono, T, Erickson, L and Kawahara, S (2016) Novel immunomodulatory effects of phytanic acid and its related substances in mice. Journal of Functional Foods 21, 283–289.CrossRefGoogle Scholar
Nakanishi, T, Motoba, I, Anraku, M, Suzuki, R, Yamaguchi, Y, Erickson, L, Eto, N, Sugamoto, K, Matsushita, Y and Kawahara, S (2018) Naturally occurring 3RS, 7R, 11R-phytanic acid suppresses in vitro T-cell production of interferon-gamma. Lipids in Health and Disease 17, 147.CrossRefGoogle ScholarPubMed
Roca-Saavedra, P, Marino-Lorenzo, P, Miranda, JM, Porto-Arias, JJ, Lamas, A, Vazquez, BI, Franco, CM and Cepeda, A (2017) Phytanic acid consumption and human health, risks, benefits and future trends: a review. Food Chemistry 221, 237–247.CrossRefGoogle ScholarPubMed
Van Veldhoven, PP, Mannaerts, GP, Casteels, M and Croes, K (1999) Hepatic alpha-oxidation of phytanic acid. A revised pathway. Advances in Experimental Medicine and Biology 466, 273–281.CrossRefGoogle ScholarPubMed
Yamada, K, Mizukoshi, E, Seike, T, Horii, R, Terashima, T, Iida, N, Kitahara, M, Sunagozaka, H, Arai, K, Yamashita, T, Honda, M, Takamura, T, Harada, K and Kaneko, S (2019) Serum C16:1n7/C16:0 ratio as a diagnostic marker for non-alcoholic steatohepatitis. Journal of Gastroenterology and Hepatology 34, 1829–1835.CrossRefGoogle ScholarPubMed
Supplementary material: PDF

Nakanishi et al. supplementary material

Nakanishi et al. supplementary material

Download Nakanishi et al. supplementary material(PDF)
PDF 161.8 KB