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Concentration of penicillin G in mammary tissue and secretion of end-term dairy heifers following systemic prepartum administration of penethamate hydriodide

Published online by Cambridge University Press:  29 September 2009

Pieter Passchyn ,
Sofie Piepers ,
Ellen Schmitt-Van de Leemput ,
Christian Guidarini  and
Sarne De Vliegher
Pieter Passchyn
Affiliation:
Department of Reproduction, Obstetrics and Herd Health, Faculty of Veterinary Medicine, Ghent University, Belgium Veterinary practice De Toren, Torhout, Belgium
Sofie Piepers
Affiliation:
Department of Reproduction, Obstetrics and Herd Health, Faculty of Veterinary Medicine, Ghent University, Belgium
Ellen Schmitt-Van de Leemput
Affiliation:
Veterinary practice, Villaines la Juhel, France
Christian Guidarini
Affiliation:
Boehringer Ingelheim Santé Animale, Reims, France
Sarne De Vliegher*
Affiliation:
Department of Reproduction, Obstetrics and Herd Health, Faculty of Veterinary Medicine, Ghent University, Belgium
*
*For correspondence; e-mail: [email protected]
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Abstract

The aim of this study was to assess the concentration of penicillin G in mammary tissue and secretion of dry heifers following systemic administration of penethamate hydriodide. Six dairy heifers in late gestation received a single intramuscular injection of 10 g penethamate hydriodide and were sacrificed 24, 48 or 144 h after treatment. Penicillin G concentrations were measured in mammary tissue and secretion samples using HPLC. Penicillin G was detected in the udder of two animals euthanized at 24 h (mammary tissue and secretion) and at 48 h post treatment (mammary secretion only) after administration at concentrations still close to or above MIC90 values reported for the pathogens associated with heifer mastitis. Antibiotic concentration shortly after administration will have been substantially higher indicating a potential for systemic treatment with penethamate hydriodide to control prepartum intramammary infections in heifers without the disadvantages of local therapy such as teat contamination or risk of trauma for the administrator.

Keywords

Dairy heiferpenethamate hydriodideprepartum treatmentsystemic
Type
Research Article
Information
Journal of Dairy Research , Volume 77 , Issue 1 , February 2010 , pp. 33 - 36
Copyright
Copyright © Proprietors of Journal of Dairy Research 2009

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