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Cardiovascular and metabolic responses during growth hormone treatment of lactating sheep

Published online by Cambridge University Press:  01 June 2009

Ivan R. Fleet ,
Frances M. Fullerton ,
R. Brian Heap ,
T. Ben Mepham ,
Peter D. Gluckman  and
Ian C. Hart
Ivan R. Fleet
Affiliation:
AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge CB2 4AT, UK
Frances M. Fullerton
Affiliation:
Department of Physiology and Environmental Science, University of Nottingham Faculty of Agricullural Science, Sutton Bonington, Loughborough, Leics LE12 5RD, UK
R. Brian Heap
Affiliation:
AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge CB2 4AT, UK
T. Ben Mepham
Affiliation:
Department of Physiology and Environmental Science, University of Nottingham Faculty of Agricullural Science, Sutton Bonington, Loughborough, Leics LE12 5RD, UK
Peter D. Gluckman
Affiliation:
Department of Pediatrics, University of Auckland, Private Bag, Auckland, New Zealand
Ian C. Hart
Affiliation:
National Institute for Research in Dairying, Shinfield, Reading RG2 9AT, UK
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Summary

Pituitary-derived bovine growth hormone (bGH) was administered to six lactating Friesland ewes for 7 d. There was no consistent galactopoietic response, with changes in milk yield varying from 0 to 33% during treatment compared with the pretreatment period. The major effect of bGH on the concentration of milk constituents was to increase fat by 14·2% (P < 0·05). Treatment resulted in significant increases in arterial plasma concentrations of growth hormone, insulin-like growth factor I and glucose, with decreases in the plasma arterial concentrations of acetate and certain amino acids. There was a marked reduction in haematocrit and in haemoglobin concentration which took at least 3 d to recover. The arterio-venous difference across the mammary gland decreased for O2 during treatment and the veno-arterial difference for CO2 decreased after treatment. Mammary respiratory quotient therefore decreased significantly after bGH treatment. The results suggest that bGH exerts effects at a number of separate loci.

Type
Original articles
Information
Journal of Dairy Research , Volume 55 , Issue 4 , November 1988 , pp. 479 - 485
Copyright
Copyright © Proprietors of Journal of Dairy Research 1988

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