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Calcium-enriched goats' milk aids recovery of iron status better than calcium-enriched cows' milk, in rats with nutritional ferropenic anaemia

Published online by Cambridge University Press:  12 May 2008

Teresa Nestares ,
Mercedes Barrionuevo ,
Javier Díaz-Castro ,
Inmaculada López-Aliaga ,
Ma José M Alférez  and
Margarita S Campos
Teresa Nestares
Affiliation:
Department of Physiology and Institute of Nutrition and Food Technology, University of Granada, E-18071 Granada, Spain
Mercedes Barrionuevo
Affiliation:
Department of Physiology and Institute of Nutrition and Food Technology, University of Granada, E-18071 Granada, Spain
Javier Díaz-Castro
Affiliation:
Department of Physiology and Institute of Nutrition and Food Technology, University of Granada, E-18071 Granada, Spain
Inmaculada López-Aliaga
Affiliation:
Department of Physiology and Institute of Nutrition and Food Technology, University of Granada, E-18071 Granada, Spain
Ma José M Alférez
Affiliation:
Department of Physiology and Institute of Nutrition and Food Technology, University of Granada, E-18071 Granada, Spain
Margarita S Campos*
Affiliation:
Department of Physiology and Institute of Nutrition and Food Technology, University of Granada, E-18071 Granada, Spain
*
*For correspondence; e-mail: [email protected]
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Abstract

Ca-Fe interactions are known, but no studies are available about the effects of Ca-enriched goat or cow milk on Fe status in nutritional ferropenic anaemia (NFA). To examine this matter, control and Fe-deficient rats were fed for 14 d with goat or cow milk diets containing either normal or high Ca content (5000 or 10 000 mg/kg diet), and different indices and parameters related to iron status were measured. The apparent digestibility coefficient (ADC) and the Fe retention/intake (R/I) ratio were higher in control and anaemic rats fed goat milk diet (G diet), despite high-Ca content. Ca enrichment decreased Fe stores in liver and sternum in anaemic rats fed cow milk diet (C diet), however G diet did not modify Fe content in the organs studied in control and anaemic rats. In anaemic rats, Ca-supplementation decreased haematocrit, but platelets and serum Fe were not affected, however, in control rats platelets increased except for Ca-enriched G diet, this fact reveals that Ca-Fe interaction is minimized with G diet. Serum ferritin was always higher in rats fed G vs. C diet, both in control and anaemic rats fed either normal or Ca-enriched diets. Ca-supplementation decreased ferritin levels in control and anaemic rats fed C diet and also, though to a lesser extent, in those given the G diet. This indicates that with this G diet there is a better recovery of body Fe stores in anaemic rats, despite Ca-supplementation. In this study it is noteworthy that despite high Ca content, a goat milk diet resulted in minimal Ca-Fe interactions and did not adversely affect Fe status in rats with NFA.

Keywords

Goat and cow milkcalcium enrichmentanaemiairon status
Type
Research Article
Information
Journal of Dairy Research , Volume 75 , Issue 2 , May 2008 , pp. 153 - 159
Copyright
Copyright © Proprietors of Journal of Dairy Research 2008

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References

Alférez, MJM, Barrionuevo, M, López-Aliaga, I, Sanz-Sampelayo, MR, Lisbona, F & Campos, MS 2001 The digestive utilization of goat and cow milk fat in malabsorption syndrome. Journal of Dairy Research 68 451–461CrossRefGoogle ScholarPubMed
Alférez, MJM, López-Aliaga, I, Nestares, T, Díaz-Castro, J, Barrionuevo, M, Ros, PB & Campos, MS 2006 Dietary goat milk improves iron bioavailability in rats with induced ferropenic anemia in comparison with cow milk. International Dairy Journal 16 813–821CrossRefGoogle Scholar
Barrionuevo, M, Alférez, MJM, López-Aliaga, I, Sanz Sampelayo, MR & Campos, MS 2002 Beneficial effect of goat milk on nutritive utilization of iron and copper in malabsorption syndrome. Journal of Dairy Science 85 657–664CrossRefGoogle ScholarPubMed
Barton, JC, Conrad, ME & Parmley, RT 1983 Calcium inhibition of inorganic iron absorption in rats. Gastroenterology 84 90–101CrossRefGoogle ScholarPubMed
Bloem, MW 1995 Interdependence of vitamin A and iron: an important association for programmes of anemia control. Proceedings of the Nutrition Society 54 501–508CrossRefGoogle Scholar
Campos, MS, Barrionuevo, M, Alférez, MJM, Gómez-Ayala, AE, Rodriguez-Matas, MC, López-Aliaga, I & Lisbona, F 1998 Interactions among iron, calcium, phosphorus and magnesium in the nutritionally iron-deficient rat. Experimental Physiology 83 771–781CrossRefGoogle ScholarPubMed
Forellat, M, Gautier, H & Fernandez, N 2000 Metabolismo del hierro. Revista Cubana de Hematología, Inmunología y Hemoterapia 16 149–160Google Scholar
García-Casal, MN, Leets, I & Layrisse, M 2000 β-carotene and inhibitors of iron absorption modify iron uptake by Caco-2 cells. Journal of Nutrition 130 5–9CrossRefGoogle ScholarPubMed
García Unciti, MS 1996 Therapeutic utility of medium chain triglycerides (MCT). Cetogenic diets in infant epilepsy. Nutrición Clínica 16 7–35Google Scholar
Glahn, RP & Van Campen, DR 1997 Iron uptake is enhanced in Caco-2 cell monolayers by cysteine and reduced cysteinyl glycine. Journal of Nutrition 127 642–647CrossRefGoogle ScholarPubMed
Gomez-Ayala, AE, Lisbona, F, López-Aliaga, I, Pallarés, I, Barrionuevo, M, Hartiti, S, Rodríguez-Matas, MC & Campos, M 1998 The absorption of iron, calcium, phosphorus, magnesium, copper and zinc in the jejunum-ileum of control and iron-deficient rats. Laboratory Animal 32 72–79CrossRefGoogle ScholarPubMed
Grinder-Pedersen, L, Bukhave, K, Jensen, M, Hejgaard, L & Hansen, M 2004 Calcium from milk or calcium-fortified foods does not inhibit nonheme iron absorption from a whole diet consumed over a 4-d period. American Journal of Clinical Nutrition 80 404–409CrossRefGoogle ScholarPubMed
Jackson, LS & Lee, K 1992 The effect of dairy products on iron availability. Critical Reviews in Food Science and Nutrition 31 259–270CrossRefGoogle ScholarPubMed
López Aliaga, I, Alférez, MJM, Barrionuevo, M, Lisbona, F & Campos, MS 2000 Influence of goat and cow milk on the digestive and metabolic utilization of calcium and iron. Journal of Physiology and Biochemistry 56 201–208CrossRefGoogle ScholarPubMed
Minihane, AM & Fairweather-Tait, SJ 1998 Effect of calcium supplementation on daily nonheme-iron absorption and long-term iron status. American Journal of Clinical Nutrition 68 96–102CrossRefGoogle ScholarPubMed
Molgaard, C, Koestel, P & Michaelsen, K 2005 Long-term calcium supplementation does not affect the iron status of 12–14-y-old girls. American Journal of Clinical Nutrition 82 98–102CrossRefGoogle Scholar
Morgan, EH & Oates, PS 2002 Mechanisms and regulation of intestinal iron absorption. Blood Cells and Molecular Diseases 29 384–399CrossRefGoogle ScholarPubMed
Pallarés, I, Lisbona, F, López-Aliaga, I, Barrionuevo, M, Alférez, MJM & Campos, MS 1993 Effects of iron deficiency on the digestive utilization of iron, phosphorus, calcium and magnesium in rats. British Journal of Nutrition 70 609–620CrossRefGoogle ScholarPubMed
Reeves, PG, Nielsen, FH & Fahey, GC 1993 AIN-93 Purified diets for laboratory rodents: final report of the American Institute of Nutrition and Ad Hoc Writing Committee on the reformulation of the AIN-76A rodent diet. Journal of Nutrition 123 1939–1951CrossRefGoogle Scholar
Sanderson, P 1986 A new method of analysis of feeding stuffs for the determination of crude oils and fat In Recent Advances in Animal Nutrition, pp. 77–80 (Eds Haresing, W & Cole, DJA) Butterworths, LondonCrossRefGoogle Scholar
Van Campen, DR 1973 Enhancement of iron absorption from ligated segments of rat intestine by histidine, cysteine and lysine: Effects of removing ionizing groups and of steroisomerism. Journal of Nutrition 103 139–142CrossRefGoogle Scholar
Viteri, FE 1993 Report to WHO on Global Strategy for the Control of Iron Deficiency. WHO Nutrition Unit, GenevaGoogle Scholar
Whittaker, P, Hines, FA, Robl, MG & Dunkel, VC 1996 Histopathological evaluation on liver, pancreas, spleen and heart from iron-overloaded Spraged-Dawley rats. Toxicologycal Pathology 24 558–563CrossRefGoogle ScholarPubMed
Wienk, KJH, Marx, JJM, Lemmens, AG, Brink, EJ, Van der Meer, R & Beynen, AC 1996 Mechanism underlying the inhibitory effect of high calcium carbonate intake on iron bioavailability from ferrous sulphate in anaemic rats. British Journal of Nutrition 75 109–120CrossRefGoogle ScholarPubMed
Wienk, KJ, Marx, JJ & Beynen, AC 1999 The concept of iron bioavailability and its assessment. European Journal of Nutrition 38 51–75CrossRefGoogle ScholarPubMed
Wood, RJ & Zheng, JJ 1997 High dietary calcium intake reduces zinc absorption and balance in humans. American Journal of Clinical Nutrition 65 1803–1809CrossRefGoogle ScholarPubMed
Yeh, KY, Yeh, M, Watkins, A, Rodríguez-Paris, J & Glass, J 2000 Dietary iron induces rapid changes in rat intestinal divalent metal transporter expression. American Journal of Physiology-Gastrointestinal and Liver Physiology 279 G1070–G1079CrossRefGoogle ScholarPubMed