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Biologically active peptides of casein and lactotransferrin implicated in platelet function

Published online by Cambridge University Press:  01 June 2009

Anne-Marie Fiat ,
Sylviane Levy-Toledano ,
Jacques P. Caen  and
Pierre Jollès
Anne-Marie Fiat
Affiliation:
Laboratoire des Protéines UA CNRS U88, Université de Paris V, 45 rue des Saints-Pères, F-75270 Paris Cedex 06, France
Sylviane Levy-Toledano
Affiliation:
Hôpital Lariboisière, INSERM U 150 and CNRS LA 334, 6 rue Guy Patin, F-75475 Paris Cedex 10, France
Jacques P. Caen
Affiliation:
Hôpital Lariboisière, INSERM U 150 and CNRS LA 334, 6 rue Guy Patin, F-75475 Paris Cedex 10, France
Pierre Jollès
Affiliation:
Laboratoire des Protéines UA CNRS U88, Université de Paris V, 45 rue des Saints-Pères, F-75270 Paris Cedex 06, France
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Summary

Casein and other milk proteins in maternal colostrum and milk, the earliest food of the newborn, should not only be considered as a nutritional supply but also as a source of biologically active peptides. Some of them isolated from casein and lactotransferrin were active on platelet function. They inhibited both aggregation of ADP-treated platelets and binding of [125I] fibrinogen to ADP-treated platelets. Their behaviour was compared to that of fibrinogen peptides possessing similar effects: once more similarities between the milk and blood-clotting phenomena could be observed.

Type
Original Articles
Information
Journal of Dairy Research , Volume 56 , Issue 3: Special Issue: Proceedings of the Hannah Research Institute Casein Conference , May 1989 , pp. 351 - 355
Copyright
Copyright © Proprietors of Journal of Dairy Research 1989

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References

REFERENCES

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